Catalog No.
RHJ89301
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
IHC: 1:500-1:1000
Target
CD2-associated protein, Adapter protein CMS, Cas ligand with multiple SH3 domains, CD2AP
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9Y5K6
Applications
IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3X71
CD2AP is Co-Expressed with Tropomyosin-Related Kinase A and Ras-Related Protein Rab-5A in Cholinergic Neurons of the Murine Basal Forebrain., PMID:39211110
Minnelide combined with anti-ANGPTL3-FLD monoclonal antibody completely protects mice with adriamycin nephropathy by promoting autophagy and inhibiting apoptosis., PMID:37689694
Genomics of Alzheimer's disease implicates the innate and adaptive immune systems., PMID:34708251
MicroRNA-548k upregulates a spliced variant of human CD2-associated protein by targeting its promoter., PMID:32608582
Tyrosine Phosphorylation of CD2AP Affects Stability of the Slit Diaphragm Complex., PMID:31235616
The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection., PMID:29734372
Urinary podocyte-associated molecules and albuminuria in hypertension., PMID:29677049
Inhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosis., PMID:28878342
NF-κB-dependent increase in tissue factor expression is responsible for hypoxic podocyte injury., PMID:26715508
Focal segmental glomerulosclerosis: molecular genetics and targeted therapies., PMID:26156092
Reticular erythematous mucinosis: histopathological and immunohistochemical features of 25 patients compared with 25 cases of lupus erythematosus tumidus., PMID:25087914
Close relations between podocyte injuries and membranous proliferative glomerulonephritis in autoimmune murine models., PMID:23817053
Expression of the CD2AP adaptor molecule in normal, reactive and neoplastic human tissue., PMID:22953501
Alzheimer's Disease: APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae, Other Suspect Pathogens, and the Immune System., PMID:22254144
Plasmacytoid dendritic cells: an overview of their presence and distribution in different inflammatory skin diseases, with special emphasis on Jessner's lymphocytic infiltrate of the skin and cutaneous lupus erythematosus., PMID:20659210
CIN85/RukL is a novel binding partner of nephrin and podocin and mediates slit diaphragm turnover in podocytes., PMID:20457601
[New functional proteins identified by proteomic analysis in the epidermal growth factor receptor-mediated signaling pathway and application for practical use]., PMID:20371988
Slit diaphragm dysfunction in proteinuric states: identification of novel therapeutic targets for nephrotic syndrome., PMID:19266252
The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm., PMID:18971929
Dissociation of NEPH1 from nephrin is involved in development of a rat model of focal segmental glomerulosclerosis., PMID:18715943
Adaptor protein Ruk/CIN85 is associated with a subset of COPI-coated membranes of the Golgi complex., PMID:18266907
Ephrin-B1 localizes at the slit diaphragm of the glomerular podocyte., PMID:17667985
Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes., PMID:17537921
Expression of adaptor protein Ruk/CIN85 isoforms in cell lines of various tissue origins and human melanoma., PMID:17285110
Synaptic vesicle protein 2B is expressed in podocyte, and its expression is altered in proteinuric glomeruli., PMID:16943307
Role of podocyte slit diaphragm as a filtration barrier., PMID:16889564
Podocyte-associated proteins FAT, alpha-actinin-4 and filtrin are expressed in Langerhans islets of the pancreas., PMID:16841182
Autocrine VEGF-A system in podocytes regulates podocin and its interaction with CD2AP., PMID:16597608
Nephrin and podocin dissociate at the onset of proteinuria in experimental membranous nephropathy., PMID:15882266
Clues to CD2-associated protein involvement in cytokinesis., PMID:15800069
CD2-associated protein in human urogenital system and in adult kidney tumours., PMID:15785926
Nephrin expression is increased in anti-Thy1.1-induced glomerulonephritis in rats., PMID:15465010
In vivo expression of podocyte slit diaphragm-associated proteins in nephrotic patients with NPHS2 mutation., PMID:15327385
A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis., PMID:15213232
Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin., PMID:15197181
Nephrin promotes cell-cell adhesion through homophilic interactions., PMID:14633607
Podocyte changes upon induction of albuminuria in Thy-1.1 transgenic mice., PMID:14605274
Podocyte changes after induction of acute albuminuria in mice by anti-aminopeptidase A mAb., PMID:12902618
Targeted downregulation of extracellular nephrin in human IgA nephropathy., PMID:12853730
In vivo expression of putative LMX1B targets in nail-patella syndrome kidneys., PMID:12819019
CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility., PMID:12764198
A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton., PMID:12672817
Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation., PMID:11956244
Nephrin dissociates from actin, and its expression is reduced in early experimental membranous nephropathy., PMID:11912254
CD2AP and p130Cas localize to different F-actin structures in podocytes., PMID:11553524
Preliminary findings of chromosomal alterations and expression of cell cycle genes in head an neck tumors., PMID:11894785
For research use only. Not for human or drug use.
