Catalog No.
RHJ82303
Species reactivity
Human, Mouse, Monkey
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, IF: 1:200-1:1000, WB: 1:500-1:2000
Target
Urate exporter, ABCP, BCRP1, ABCG2, CD338, BCRP, MXR, Broad substrate specificity ATP-binding cassette transporter ABCG2, Placenta-specific ATP-binding cassette transporter, Breast cancer resistance protein, Mitoxantrone resistance-associated protein, CDw338, ATP-binding cassette sub-family G member 2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9UNQ0
Applications
ELISA, IF, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3X56
Genotype Analysis of the JR Blood Group in an East Asian Population Using Tetra-Primer ARMS-PCR., PMID:39293835
Magnolol derivatives as specific and noncytotoxic inhibitors of breast cancer resistance protein (BCRP/ABCG2)., PMID:38513324
Tumor-acquired somatic mutation affects conformation to abolish ABCG2-mediated drug resistance., PMID:38387283
Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies., PMID:37597690
Noninvasive Evaluation of Multidrug Resistance via Imaging of ABCG2/BCRP Multidrug Transporter in Lung Cancer Xenograft Models., PMID:35427142
A new porphyrin as selective substrate-based inhibitor of breast cancer resistance protein (BCRP/ABCG2)., PMID:34717915
Flavonoid Monomers as Potent, Nontoxic, and Selective Modulators of the Breast Cancer Resistance Protein (ABCG2)., PMID:34606270
Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism., PMID:34282134
Altered Profile of E1-S Transporters in Endometrial Cancer: Lower Protein Levels of ABCG2 and OSTβ and Up-Regulation of SLCO1B3 Expression., PMID:33917029
Calcium channel α2δ1 subunit is a functional marker and therapeutic target for tumor-initiating cells in non-small cell lung cancer., PMID:33707423
A Combined Bioinformatic and Nanoparticle-Based Study Reveal the Role of ABCG2 in the Drug Resistant Breast Cancer., PMID:33602075
Mechanistic basis of breast cancer resistance protein inhibition by new indeno[1,2-b]indoles., PMID:33469044
The Role of Specific ATP-Binding Cassette Transporters in the Acquired Resistance to Pyrrolobenzodiazepine Dimer-Containing Antibody-Drug Conjugates., PMID:32669316
Mirror syndrome due to anti-Jra alloimmunization., PMID:32416899
[Isolation and Biological Characterization of Lung Cancer Stem Cells]., PMID:32131936
Cetuximab enhances the efficiency of irinotecan through simultaneously inhibiting the MAPK signaling and ABCG2 in colorectal cancer cells., PMID:31889589
Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states., PMID:30405239
Immuno-oncology agent IPI-549 is a modulator of P-glycoprotein (P-gp, MDR1, ABCB1)-mediated multidrug resistance (MDR) in cancer: In vitro and in vivo., PMID:30391357
Synthesis and biological evaluation of quinazoline derivatives - A SAR study of novel inhibitors of ABCG2., PMID:30390439
Comprehensive preclinical pharmacokinetic evaluations of trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody-drug conjugate, in cynomolgus monkeys., PMID:30351177
Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells., PMID:30315846
2,4,6-Substituted Quinazolines with Extraordinary Inhibitory Potency toward ABCG2., PMID:30075623
Regulation of Human γδ T Cells by BTN3A1 Protein Stability and ATP-Binding Cassette Transporters., PMID:29670629
New Inhibitors of Breast Cancer Resistance Protein (ABCG2) Containing a 2,4-Disubstituted Pyridopyrimidine Scaffold., PMID:29547272
Pharmacogenetics of the anti-HCV drug sofosbuvir: a preliminary study., PMID:29509884
Broad blocking of MDR efflux pumps by acetylshikonin and acetoxyisovalerylshikonin to generate hypersensitive phenotype of malignant carcinoma cells., PMID:29472576
Human aniridia limbal epithelial cells lack expression of keratins K3 and K12., PMID:29162348
ABC-transporter blockage mediated by xanthotoxin and bergapten is the major pathway for chemosensitization of multidrug-resistant cancer cells., PMID:29079042
Structure of the human multidrug transporter ABCG2., PMID:28554189
Cetuximab Prevents Methotrexate-Induced Cytotoxicity in Vitro through Epidermal Growth Factor Dependent Regulation of Renal Drug Transporters., PMID:28493713
Circulating intestine-derived exosomal miR-328 in plasma, a possible biomarker for estimating BCRP function in the human intestines., PMID:27571936
An automated method measures variability in P-glycoprotein and ABCG2 densities across brain regions and brain matter., PMID:27488911
Antibody validation and scoring guidelines for ABCG2 immunohistochemical staining in formalin-fixed paraffin-embedded colon cancer tissue., PMID:27257141
FOXP1 functions as an oncogene in promoting cancer stem cell-like characteristics in ovarian cancer cells., PMID:26654944
Target therapy of multiple myeloma by PTX-NPs and ABCG2 antibody in a mouse xenograft model., PMID:26314844
Suspected anemia caused by maternal anti-Jra antibodies: a case report., PMID:26301094
Inhibitory effect of epirubicin-loaded lipid microbubbles with conjugated anti-ABCG2 antibody combined with therapeutic ultrasound on multiple myeloma cancer stem cells., PMID:26204324
Reversal of P-gp and BCRP-mediated MDR by tariquidar derivatives., PMID:26197160
Quantum dot labeling and tracking of cultured limbal epithelial cell transplants in vitro., PMID:26024089
Endocytosis of ABCG2 drug transporter caused by binding of 5D3 antibody: trafficking mechanisms and intracellular fate., PMID:25918011
Breast cancer resistance protein identifies clonogenic keratinocytes in human interfollicular epidermis., PMID:25881149
Comparison of Explant and Enzyme Digestion Methods for Ex Vivo Isolation of Limbal Epithelial Progenitor Cells., PMID:25860821
Safety profile of accelerated corneal cross-linking versus conventional cross-linking: a comparative study on ex vivo-cultured limbal epithelial cells., PMID:25488945
ABCG2-meditated multidrug resistance and tumor-initiating capacity of side population cells from colon cancer., PMID:25427584
PTEN loss-mediated Akt activation increases the properties of cancer stem-like cell populations in prostate cancer., PMID:25139413
ABCG2 is a selectable marker for enhanced multilineage differentiation potential in periodontal ligament stem cells., PMID:25101689
Immunolocalization of ABC drug transporters in human placenta from normal and gestational diabetic pregnancies., PMID:25029804
Motesanib (AMG706), a potent multikinase inhibitor, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1., PMID:24937702
WHI-P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells., PMID:24903205
Gamma-Fe2O3 nanoparticles increase therapeutic efficacy of combination with paclitaxel and anti-ABCG2 monoclonal antibody on multiple myeloma cancer stem cells in mouse model., PMID:24738341
For research use only. Not for human or drug use.
