Catalog No.
RHJ76602
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, WB: 1:500-1:2000
Target
A disintegrin and metalloproteinase with thrombospondin motifs 1, ADAM-TS 1, ADAM-TS1, ADAMTS1, METH1, METH-1, KIAA1346, ADAMTS-1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9UHI8
Applications
ELISA, FCM, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3X36
Cleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis and other forms of degenerative joint disease., PMID:39672391
Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development., PMID:38750698
An anti-ADAMTS1 treatment relieved muscle dysfunction and fibrosis in dystrophic mice., PMID:34175316
Inhibition of PDGF-BB reduces alkali-induced corneal neovascularization in mice., PMID:33537811
Immunogenic hotspots in the spacer domain of ADAMTS13 in immune-mediated thrombotic thrombocytopenic purpura., PMID:33171004
Pro-atherogenic proteoglycanase ADAMTS-1 is down-regulated by lauric acid through PI3K and JNK signaling pathways in THP-1 derived macrophages., PMID:30989556
Selenium nanoparticles for targeted stroke therapy through modulation of inflammatory and metabolic signaling., PMID:30988361
Aggrecanase degradation of type III collagen is associated with clinical knee pain., PMID:29702061
IL-20 contributes to low grade inflammation and weight gain in the Psammomys obesus., PMID:28187313
The Investigation of a Disintegrin and Metalloproteinase with ThromboSpondin Motifs (ADAMTS) 1, 5 and 16 in Thoracic Aortic Aneurysms and Dissections., PMID:27156333
Increased ADAMTS1 mediates SPARC-dependent collagen deposition in the aging myocardium., PMID:27143554
Determinants of versican-V1 proteoglycan processing by the metalloproteinase ADAMTS5., PMID:25122765
Paradoxic effects of metformin on endothelial cells and angiogenesis., PMID:24419232
Alterations in junctional proteins, inflammatory mediators and extracellular matrix molecules in eosinophilic esophagitis., PMID:23792687
Decreased expression of ADAMTS-1 in human breast tumors stimulates migration and invasion., PMID:23289900
Inhibition of tumor growth by antibody to ADAMTS1 in mouse xenografts of breast cancer., PMID:22110207
Comparison of ADAMTS-1, -4 and -5 expression in culprit plaques between acute myocardial infarction and stable angina., PMID:21345877
[Effect of ischemia preconditioning on pro- and anti- angiogenic molecule expression and functional arteries formation]., PMID:21092652
PGF2α-F-prostanoid receptor signalling via ADAMTS1 modulates epithelial cell invasion and endothelial cell function in endometrial cancer., PMID:20840749
Cytokine-induced increases in ADAMTS-4 messenger RNA expression do not lead to increased aggrecanase activity in ADAMTS-5-deficient mice., PMID:20662062
Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome., PMID:20535211
RETRACTED: Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1., PMID:20103648
Proteolytic cleavage of versican during limb joint development., PMID:20101710
Differential effects of ADAMTS-1, -4, and -5 in the trabecular meshwork., PMID:19553617
Proteolytic processing causes extensive heterogeneity of tissue matrilin forms., PMID:19531486
Opposite roles of CCR2 and CX3CR1 macrophages in alkali-induced corneal neovascularization., PMID:19421039
ADAMTS-1 metalloproteinase promotes tumor development through the induction of a stromal reaction in vivo., PMID:19010931
Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes., PMID:18662930
Expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic cartilage., PMID:17922681
Expression of extracellular matrix proteins fibulin-1 and fibulin-2 by human corneal fibroblasts., PMID:17612964
Expression and significance of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 in an animal model of renal interstitial fibrosis induced by unilateral ureteral obstruction., PMID:17583485
Aggrecanolysis in human osteoarthritis: confocal localization and biochemical characterization of ADAMTS5-hyaluronan complexes in articular cartilages., PMID:17360199
ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2., PMID:17082774
Oxidized phospholipids stimulate angiogenesis via autocrine mechanisms, implicating a novel role for lipid oxidation in the evolution of atherosclerotic lesions., PMID:16973904
Amino acid regions 572-579 and 657-666 of the spacer domain of ADAMTS13 provide a common antigenic core required for binding of antibodies in patients with acquired TTP., PMID:16953270
Vascular endothelial growth factor upregulates expression of ADAMTS1 in endothelial cells through protein kinase C signaling., PMID:16936124
Use of ticlopidine and cilostazol after intracoronary drug-eluting stent placement in a patient with previous clopidogrel-induced thrombotic thrombocytopenic purpura: a case report., PMID:16816452
Proteolytic cleavage of versican during cardiac cushion morphogenesis., PMID:16691565
Differential effects of interleukin-1beta and transforming growth factor-beta1 on the expression of the inflammation-associated protein, ADAMTS-1, in human decidual stromal cells in vitro., PMID:16675485
A quantitative assay for aggrecanase activity., PMID:16522869
Platelet-derived VWF-cleaving metalloprotease ADAMTS-13., PMID:16176307
Distribution patterns of the anti-angiogenic protein ADAMTS-1 during rat development., PMID:15878613
The hyalectan degrading ADAMTS-1 enzyme is expressed by osteoblasts and up-regulated at regions of new bone formation., PMID:15777654
Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease., PMID:15661359
Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulation., PMID:15659705
ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage., PMID:15296936
Destruction of extracellular matrix proteoglycans is pervasive in simian retroviral neuroinfection., PMID:15262273
ADAMTS-1, a gene product of articular chondrocytes in vivo and in vitro, is downregulated by interleukin 1beta., PMID:14760803
Processing and localization of ADAMTS-1 and proteolytic cleavage of versican during cumulus matrix expansion and ovulation., PMID:12907688
Baculoviral expression of correctly processed ADAMTS proteins fused with the human IgG-Fc region., PMID:12443850
For research use only. Not for human or drug use.
