Catalog No.
RHJ72201
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000
Target
M.HsaIIIB, DNA (cytosine-5)-methyltransferase 3B, Dnmt3b, DNA methyltransferase HsaIIIB, DNA MTase HsaIIIB, DNMT3B
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9UBC3
Applications
ELISA, FCM, IF
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3X23
The de novo DNA methyltransferase 3B is a novel epigenetic regulator of MYC in multiple myeloma, representing a promising therapeutic target to counter relapse., PMID:40241199
Combined Effect of Conventional Chemotherapy with Epigenetic Modulators on Glioblastoma., PMID:40004468
Exploring the intersection of epigenetics, DNA repair, and immunology from studies of ICF syndrome, an inborn error of immunity., PMID:38799442
Silencing of forkhead box C1 reduces nasal epithelial barrier damage in mice with allergic rhinitis via epigenetically upregulating secreted frizzled-related protein 5., PMID:38422887
Amino acids analysis reveals serum methionine contributes to diagnosis of the Kawasaki disease in mice and children., PMID:38008045
Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24., PMID:37990035
Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart., PMID:37101286
Characterization of a mouse model of ICF syndrome reveals enhanced CD19 activation in inducing hypogammaglobulinemia., PMID:36945532
Porcine Epidemic Diarrhea Virus nsp13 Protein Downregulates Neonatal Fc Receptor Expression by Causing Promoter Hypermethylation through the NF-κB Signaling Pathway., PMID:36602596
Autoimmunity in monogenic combined immune deficiencies with associated or syndromic features., PMID:36544766
[Mechanism of Mycobacterium tuberculosis on interleukin-6 receptor 3'-untranslated region methylation in CD4+T cells]., PMID:35381636
Huaier attenuates the adverse effects of pyroptosis by regulating the methylation of rat mesangial cells: an in vitro study., PMID:35351070
Global DNA methylation and increased DNMT3A expression in multiple myeloma patients., PMID:35173353
T Cell Repertoire Abnormality in Immunodeficiency Patients with DNA Repair and Methylation Defects., PMID:34825286
MALAT1 Promotes Tumorigenesis and Increases Cellular Sensitivity to Herceptin in HER2-positive Breast Cancer., PMID:34148540
Immunodeficiency, Centromeric Region Instability, and Facial Anomalies Syndrome (ICF) in a Boy with Variable Clinical and Immunological Presentations., PMID:33904683
Peripheral blood mononuclear cells are hypomethylated in active rheumatoid arthritis and methylation correlates with disease activity., PMID:33200208
Investigation of GSTP1 and epigenetic regulators expression pattern in a population of Iranian patients with prostate cancer., PMID:32831196
Melatonin-induced suppression of DNA methylation promotes odontogenic differentiation in human dental pulp cells., PMID:32718272
Clinical, Immunologic and Molecular Spectrum of Patients with Immunodeficiency, Centromeric Instability, and Facial Anomalies (ICF) Syndrome: A Systematic Review., PMID:32533820
Association analysis of DNA methyltransferases in IgA nephropathy., PMID:31931367
Epigenetics and prostate cancer: defining the timing of DNA methyltransferase deregulation during prostate cancer progression., PMID:31864524
Comprehensive bioinformatics study reveals targets and molecular mechanism of hesperetin in overcoming breast cancer chemoresistance., PMID:31659695
Regulation of DNA methylation levels in the process of oral mucosal regeneration in a rat oral ulcer model., PMID:31286466
Structural basis of specific DNA binding by the transcription factor ZBTB24., PMID:31226215
Blockade of TNFα to Improve Human CD34+ Cell Repopulating Activity in Allogeneic Stem Cell Transplantation., PMID:30723481
Effect of in ovo feeding of vitamin C on antioxidation and immune function of broiler chickens., PMID:30621801
Improved early development of porcine cloned embryos by treatment with quisinostat, a potent histone deacetylase inhibitor., PMID:30587665
Three Types of Immunodeficiency, Centromeric Instability, and Facial Anomalies (ICF) Syndrome Identified by Whole-Exome Sequencing in Saudi Hypogammaglobulinemia Patients: Clinical, Molecular, and Cytogenetic Features., PMID:30511102
Long noncoding RNA HOXB13-AS1 regulates HOXB13 gene methylation by interacting with EZH2 in glioma., PMID:30105866
B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation., PMID:29765016
Expression of proteins upregulated in hepatocellular carcinoma in patients with alcoholic hepatitis (AH) compared to non-alcoholic steatohepatitis (NASH): An immunohistochemical analysis of candidate proteins., PMID:29425759
Iodine excess did not affect the global DNA methylation status and DNA methyltransferase expression in T and B lymphocytes from NOD.H-2h4 and Kunming mice., PMID:29253821
Expanding the mutation spectrum in ICF syndrome: Evidence for a gender bias in ICF2., PMID:28128455
Oct4 Methylation-Mediated Silencing As an Epigenetic Barrier Preventing Müller Glia Dedifferentiation in a Murine Model of Retinal Injury., PMID:27895551
Vesicourethral reflux-induced renal failure in a patient with ICF syndrome due to a novel DNMT3B mutation., PMID:27604394
Genetic, Cellular and Clinical Features of ICF Syndrome: a French National Survey., PMID:26851945
Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts., PMID:26667266
De novo DNA Methyltransferases Dnmt3a and Dnmt3b regulate the onset of Igκ light chain rearrangement during early B-cell development., PMID:26059604
A modular open platform for systematic functional studies under physiological conditions., PMID:26007658
DNA methyltransferase3a expression is an independent poor prognostic indicator in gastric cancer., PMID:25009393
Germline genes hypomethylation and expression define a molecular signature in peripheral blood of ICF patients: implications for diagnosis and etiology., PMID:24742017
Association of the DNMT3B -579G>T polymorphism with risk of thymomas in patients with myasthenia gravis., PMID:24260492
Upregulation of DNMT1 mediated by HBx suppresses RASSF1A expression independent of DNA methylation., PMID:24247422
AICAR sustains J1 mouse embryonic stem cell self-renewal and pluripotency by regulating transcription factor and epigenetic modulator expression., PMID:23988673
Hypomethylation and activation of syncytin-1 gene in endometriotic tissue., PMID:23888948
Development of an intracellular, DNA methyltransferase-specific, and gene-specific assay for studying dynamic DNA methylation., PMID:23888947
Heterogeneous clinical presentation in ICF syndrome: correlation with underlying gene defects., PMID:23486536
450K-array analysis of chronic lymphocytic leukemia cells reveals global DNA methylation to be relatively stable over time and similar in resting and proliferative compartments., PMID:22922567
Gene silencing of EREG mediated by DNA methylation and histone modification in human gastric cancers., PMID:22508389
For research use only. Not for human or drug use.
