Catalog No.
RHJ64701
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400
Target
Deubiquitinating enzyme CYLD, Ubiquitin-specific-processing protease CYLD, Ubiquitin carboxyl-terminal hydrolase CYLD, CYLD1, KIAA0849, Ubiquitin thioesterase CYLD, CYLD
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9NQC7
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3W86
Exploration of genetic characterization in hyperprogressive disease after immunotherapy retreatment in a patient with LCNEC: A case report., PMID:38348622
MALT1-dependent cleavage of CYLD promotes NF-κB signaling and growth of aggressive B-cell receptor-dependent lymphomas., PMID:36922488
The Tumour Suppressor CYLD Is Required for Clathrin-Mediated Endocytosis of EGFR and Cetuximab-Induced Apoptosis in Head and Neck Squamous Cell Carcinoma., PMID:35008337
Molecular predictors of response to pembrolizumab in thymic carcinoma., PMID:34622229
Down-regulation of cylindromatosis protein phosphorylation by BTK inhibitor promotes apoptosis of non-GCB-diffuse large B-cell lymphoma., PMID:33827598
Cellular and Mathematical Analyses of LUBAC Involvement in T Cell Receptor-Mediated NF-κB Activation Pathway., PMID:33329596
MiR-106b promotes therapeutic antibody expression in CHO cells by targeting deubiquitinase CYLD., PMID:31292678
Deletion of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 in Mouse T Cells Protects Against Development of Autoimmune Arthritis but Leads to Spontaneous Osteoporosis., PMID:31259485
Elevated Kallikrein-binding protein in diabetes impairs wound healing through inducing macrophage M1 polarization., PMID:31182110
Aberrant Wnt signaling in multiple myeloma: molecular mechanisms and targeting options., PMID:30770859
Inactivation of deubiquitinase CYLD enhances therapeutic antibody production in Chinese hamster ovary cells., PMID:29766242
Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKKε/TBK1 as a Case Study., PMID:29755980
Deubiquitinases A20 and CYLD modulate costimulatory signaling via CD137 (4-1BB)., PMID:29296520
CP5 system, for simple and highly efficient protein purification with a C-terminal designed mini tag., PMID:28542437
Dehydroleucodine Induces a TP73-dependent Transcriptional Regulation of Multiple Cell Death Target Genes in Human Glioblastoma Cells., PMID:27671304
CYLD deletion triggers nuclear factor-κB-signaling and increases cell death resistance in murine hepatocytes., PMID:25493017
Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy., PMID:25071012
IKK regulates the deubiquitinase CYLD at the postsynaptic density., PMID:24928390
Tumor suppressor cylindromatosis (CYLD) controls HIV transcription in an NF-κB-dependent manner., PMID:24760882
Effects of low-dose cyclophosphamide with piroxicam on tumour neovascularization in a canine oral malignant melanoma-xenografted mouse model., PMID:23890026
CYLD enhances severe listeriosis by impairing IL-6/STAT3-dependent fibrin production., PMID:23825949
Clinical significance of down-regulated cylindromatosis gene in chronic lymphocytic leukemia., PMID:23725390
Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma., PMID:17692805
Negative regulation of JNK signaling by the tumor suppressor CYLD., PMID:15496400
Analysis of DNA copy number aberrations in hepatitis C virus-associated hepatocellular carcinomas by conventional CGH and array CGH., PMID:15133472
For research use only. Not for human or drug use.
