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Anti-CYLD Antibody (R3W86)

Catalog #:   RHJ64701 Specific References (25) DATASHEET
Host species: Mouse
Isotype: IgG1
Applications: ELISA, FCM
Accession: Q9NQC7
Overview

Catalog No.

RHJ64701

Species reactivity

Human

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

ELISA: 1:10000, FCM: 1:200-1:400

Target

Deubiquitinating enzyme CYLD, Ubiquitin-specific-processing protease CYLD, Ubiquitin carboxyl-terminal hydrolase CYLD, CYLD1, KIAA0849, Ubiquitin thioesterase CYLD, CYLD

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9NQC7

Applications

ELISA, FCM

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3W86

Data Image
  • Flow Cytometry
    Flow cytometric analysis of Hela cells using CYLD mouse mAb (green) and negative control (red).
References

Exploration of genetic characterization in hyperprogressive disease after immunotherapy retreatment in a patient with LCNEC: A case report., PMID:38348622

MALT1-dependent cleavage of CYLD promotes NF-κB signaling and growth of aggressive B-cell receptor-dependent lymphomas., PMID:36922488

The Tumour Suppressor CYLD Is Required for Clathrin-Mediated Endocytosis of EGFR and Cetuximab-Induced Apoptosis in Head and Neck Squamous Cell Carcinoma., PMID:35008337

Molecular predictors of response to pembrolizumab in thymic carcinoma., PMID:34622229

Down-regulation of cylindromatosis protein phosphorylation by BTK inhibitor promotes apoptosis of non-GCB-diffuse large B-cell lymphoma., PMID:33827598

Cellular and Mathematical Analyses of LUBAC Involvement in T Cell Receptor-Mediated NF-κB Activation Pathway., PMID:33329596

MiR-106b promotes therapeutic antibody expression in CHO cells by targeting deubiquitinase CYLD., PMID:31292678

Deletion of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 in Mouse T Cells Protects Against Development of Autoimmune Arthritis but Leads to Spontaneous Osteoporosis., PMID:31259485

Elevated Kallikrein-binding protein in diabetes impairs wound healing through inducing macrophage M1 polarization., PMID:31182110

Aberrant Wnt signaling in multiple myeloma: molecular mechanisms and targeting options., PMID:30770859

Inactivation of deubiquitinase CYLD enhances therapeutic antibody production in Chinese hamster ovary cells., PMID:29766242

Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKKε/TBK1 as a Case Study., PMID:29755980

Deubiquitinases A20 and CYLD modulate costimulatory signaling via CD137 (4-1BB)., PMID:29296520

CP5 system, for simple and highly efficient protein purification with a C-terminal designed mini tag., PMID:28542437

Dehydroleucodine Induces a TP73-dependent Transcriptional Regulation of Multiple Cell Death Target Genes in Human Glioblastoma Cells., PMID:27671304

CYLD deletion triggers nuclear factor-κB-signaling and increases cell death resistance in murine hepatocytes., PMID:25493017

Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy., PMID:25071012

IKK regulates the deubiquitinase CYLD at the postsynaptic density., PMID:24928390

Tumor suppressor cylindromatosis (CYLD) controls HIV transcription in an NF-κB-dependent manner., PMID:24760882

Effects of low-dose cyclophosphamide with piroxicam on tumour neovascularization in a canine oral malignant melanoma-xenografted mouse model., PMID:23890026

CYLD enhances severe listeriosis by impairing IL-6/STAT3-dependent fibrin production., PMID:23825949

Clinical significance of down-regulated cylindromatosis gene in chronic lymphocytic leukemia., PMID:23725390

Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma., PMID:17692805

Negative regulation of JNK signaling by the tumor suppressor CYLD., PMID:15496400

Analysis of DNA copy number aberrations in hepatitis C virus-associated hepatocellular carcinomas by conventional CGH and array CGH., PMID:15133472

Datasheet

Document Download

Anti-CYLD Antibody (R3W86).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

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For research use only. Not for human or drug use.

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Anti-CYLD Antibody (R3W86) [RHJ64701]
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