Catalog No.
RHJ63502
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000, IHC: 1:200-1:1000
Target
RENOX, NOX4, Renal NAD(P)H-oxidase, NADPH oxidase 4, Kidney oxidase-1, Kidney superoxide-producing NADPH oxidase, KOX-1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9NPH5
Applications
ELISA, FCM, IF, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3W79
PCL-PEtOx-based Crystalline-core Micelles for the Targeted Delivery of Paclitaxel and Trabectedin in Ovarian Cancer Therapy., PMID:40306394
Examining the Relationship Between Polystyrene Microplastics and Male Fertility: Insights From an In Vivo Study and In Vitro Sertoli Cell Culture., PMID:39376189
Targeting TGF-β signaling, oxidative stress, and cellular senescence rescues osteoporosis in gerodermia osteodysplastica., PMID:39234801
Oleic acid-induced metastasis of KRAS/p53-mutant colorectal cancer relies on concurrent KRAS activation and IL-8 expression bypassing EGFR activation., PMID:37649607
Obesity Contributes to Transformation of Myometrial Stem-Cell Niche to Leiomyoma via Inducing Oxidative Stress, DNA Damage, Proliferation, and Extracellular Matrix Deposition., PMID:37628676
Chronic SIRT1 supplementation in diabetic mice improves endothelial function by suppressing oxidative stress., PMID:37401647
Histological and biochemical evaluation of the effects of silver nanoparticles (AgNps) versus titanium dioxide nanoparticles (TiO2NPs) on rat parotid gland., PMID:37132546
VEGF-A: A Novel Mechanistic Link Between CYP2C-Derived EETs and Nox4 in Diabetic Kidney Disease., PMID:36662655
Lung Inflammasome Activation in SARS-CoV-2 Post-Mortem Biopsies., PMID:36361818
Phenytoin induces connective tissue growth factor (CTGF/CCN2) production through NADPH oxidase 4-mediated latent TGFβ1 activation in human gingiva fibroblasts: Suppression by curcumin., PMID:36205057
Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury., PMID:35806094
NADPH oxidase 4 signaling in a ventilator-induced lung injury mouse model., PMID:35346198
eNAMPT Is a Novel Damage-associated Molecular Pattern Protein That Contributes to the Severity of Radiation-induced Lung Fibrosis., PMID:35167418
NOX4 stimulates ANF secretion via activation of the Sirt1/Nrf2/ATF3/4 axis in hypoxic beating rat atria., PMID:35029280
Artificial Neural Network Analysis-Based Immune-Related Signatures of Primary Non-Response to Infliximab in Patients With Ulcerative Colitis., PMID:34992592
Di-Tyrosine Crosslinking and NOX4 Expression as Oxidative Pathological Markers in the Lungs of Patients with Idiopathic Pulmonary Fibrosis., PMID:34829703
Free Radical-Mediated Protein Radical Formation in Differentiating Monocytes., PMID:34576127
NOX4 Signaling Mediates Cancer Development and Therapeutic Resistance through HER3 in Ovarian Cancer Cells., PMID:34209278
Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury., PMID:34108253
Oxidative Stress-Induced Sirtuin1 Downregulation Correlates to HIF-1α, GLUT-1, and VEGF-A Upregulation in Th1 Autoimmune Hashimoto's Thyroiditis., PMID:33916948
Inhibition of Cochlear HMGB1 Expression Attenuates Oxidative Stress and Inflammation in an Experimental Murine Model of Noise-Induced Hearing Loss., PMID:33916471
Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment., PMID:33777671
Co-delivery of siPTPN13 and siNOX4 via (myo)fibroblast-targeting polymeric micelles for idiopathic pulmonary fibrosis therapy., PMID:33537085
Micellar Casein and Whey Powder Hold a TGF-β Activity and Regulate ID Genes In Vitro., PMID:33477984
TGF-β Activity of a Demineralized Bone Matrix., PMID:33440877
Wound Healing After Alkali Burn Injury of the Cornea Involves Nox4-Type NADPH Oxidase., PMID:33079994
Differential effects of risuteganib and bevacizumab on AMD cybrid cells., PMID:33075294
CD248 as a novel therapeutic target in pulmonary arterial hypertension., PMID:32997414
TGF-β Activity Related to the Use of Collagen Membranes: In Vitro Bioassays., PMID:32927851
Effect of NADPH oxidase inhibitors in an experimental retinal model of excitotoxicity., PMID:32916159
Tumor-Resident Stromal Cells Promote Breast Cancer Invasion through Regulation of the Basal Phenotype., PMID:32868298
Inhibition of RNA-binding protein HuR reduces glomerulosclerosis in experimental nephritis., PMID:32478392
Interplay between RNA-binding protein HuR and Nox4 as a novel therapeutic target in diabetic kidney disease., PMID:32240965
NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors., PMID:32122909
TGF-β3 Induces Autophagic Activity by Increasing ROS Generation in a NOX4-Dependent Pathway., PMID:32082074
Role of Endothelial ADAM17 in Early Vascular Changes Associated with Diabetic Retinopathy., PMID:32024241
Nox4-mediated ROS production is involved, but not essential for TGFβ-induced lens EMT leading to cataract., PMID:31926131
Cyba-deficient mice display an increase in hematopoietic stem cells and an overproduction of immunoglobulins., PMID:31919083
Dexamethasone and Tofacitinib suppress NADPH oxidase expression and alleviate very-early-onset ileocolitis in mice deficient in GSH peroxidase 1 and 2., PMID:31689440
Tachycardia-induced CD44/NOX4 signaling is involved in the development of atrial remodeling., PMID:31419440
Dulaglutide inhibits high glucose- induced endothelial dysfunction and NLRP3 inflammasome activation., PMID:31302140
Tubular NOX4 expression decreases in chronic kidney disease but does not modify fibrosis evolution., PMID:31247506
A novel NADPH oxidase inhibitor targeting Nox4 in TGFβ-induced lens epithelial to mesenchymal transition., PMID:31189078
Dulaglutide mitigates inflammatory response in fibroblast-like synoviocytes., PMID:31185450
Guidelines for the Detection of NADPH Oxidases by Immunoblot and RT-qPCR., PMID:31172474
Intravenous administration of cardiac progenitor cell-derived exosomes protects against doxorubicin/trastuzumab-induced cardiac toxicity., PMID:31098627
Tumor necrosis factor alpha has a crucial role in increased reactive oxygen species production in platelets of mice injected with lipopolysaccharide., PMID:31076004
Vascular smooth muscle-MAPK14 is required for neointimal hyperplasia by suppressing VSMC differentiation and inducing proliferation and inflammation., PMID:30771750
Paricalcitol attenuates TGF-β1-induced phenotype transition of human peritoneal mesothelial cells (HPMCs) via modulation of oxidative stress and NLRP3 inflammasome., PMID:30354670
NADPH oxidase 4 regulates anoikis resistance of gastric cancer cells through the generation of reactive oxygen species and the induction of EGFR., PMID:30237423
For research use only. Not for human or drug use.
