Catalog No.
RHJ45802
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000, IHC: 1:200-1:1000
Target
ASK1, MAPK/ERK kinase kinase 5, MEKK5, MAPKKK5, MEKK 5, Apoptosis signal-regulating kinase 1, ASK-1, Mitogen-activated protein kinase kinase kinase 5, MAP3K5, MEK kinase 5
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q99683
Applications
ELISA, FCM, IF, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3W04
Titanium Dioxide Nanoparticles Exacerbate Allergic Airway Inflammation via TXNIP Upregulation in a Mouse Model of Asthma., PMID:34576095
Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells., PMID:30315846
Killing of Latently HIV-Infected CD4 T Cells by Autologous CD8 T Cells Is Modulated by Nef., PMID:30254642
A novel synthetic analogue of ω-3 17,18-epoxyeicosatetraenoic acid activates TNF receptor-1/ASK1/JNK signaling to promote apoptosis in human breast cancer cells., PMID:28798154
MPTP activates ASK1-p38 MAPK signaling pathway through TNF-dependent Trx1 oxidation in parkinsonism mouse model., PMID:26164633
Atmospheric gas plasma-induced ROS production activates TNF-ASK1 pathway for the induction of melanoma cancer cell apoptosis., PMID:24574456
Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo., PMID:24342772
Apoptosis signal-regulating kinase 1 is involved in WISP-1-promoted cell motility in human oral squamous cell carcinoma cells., PMID:24205072
Effects of butyltins on mitogen-activated-protein kinase kinase kinase and Ras activity in human natural killer cells., PMID:24038145
Requirement of apoptosis-inducing kinase 1 for the induction of bronchial asthma following stimulation with ovalbumin., PMID:23921222
CTGF increases IL-6 expression in human synovial fibroblasts through integrin-dependent signaling pathway., PMID:23227240
Stress-induced nuclear import of apoptosis signal-regulating kinase 1 is mediated by karyopherin α2/β1 heterodimer., PMID:23123190
ASK1 promotes apoptosis of normal and malignant plasma cells., PMID:22723553
Apoptosis signal-regulating kinase 1 is mediated in TNF-α-induced CCL2 expression in human synovial fibroblasts., PMID:22711527
Potential characteristics of stem cells from human exfoliated deciduous teeth compared with bone marrow-derived mesenchymal stem cells for mineralized tissue-forming cell biology., PMID:22099898
Arginine methylation-dependent regulation of ASK1 signaling by PRMT1., PMID:22095282
Apoptosis signal-regulating kinase (ASK)-1 mediates apoptosis through activation of JNK1 following engagement of membrane immunoglobulin., PMID:19766627
Inhibition of apoptosis signal-regulating kinase 1 reduces endoplasmic reticulum stress and nuclear huntingtin fragments in a mouse model of Huntington disease., PMID:19646509
Lipopolysaccharide triggered TNF-alpha-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model., PMID:19446916
Overexpression of REIC/Dkk-3 in normal fibroblasts suppresses tumor growth via induction of interleukin-7., PMID:19279003
4-Hydroxynonenal self-limits fas-mediated DISC-independent apoptosis by promoting export of Daxx from the nucleus to the cytosol and its binding to Fas., PMID:18069800
RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation., PMID:17389591
Inhibition of lymphotoxin-beta receptor-mediated cell death by survivin-DeltaEx3., PMID:16540654
15S-Lipoxygenase-2 mediates arachidonic acid-stimulated adhesion of human breast carcinoma cells through the activation of TAK1, MKK6, and p38 MAPK., PMID:16000313
Important role of apoptosis signal-regulating kinase 1 in ischemia-induced angiogenesis., PMID:15976330
Direct binding of apoptosis signal-regulating kinase 1 to retinoblastoma protein: novel links between apoptotic signaling and cell cycle machinery., PMID:15210709
The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization., PMID:12829723
Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death., PMID:12786973
The role of apoptosis signal-regulating kinase 1 in lymphotoxin-beta receptor-mediated cell death., PMID:12566458
Double-stranded RNA-activated protein kinase interacts with apoptosis signal-regulating kinase 1. Implications for apoptosis signaling pathways., PMID:12473108
For research use only. Not for human or drug use.
