Catalog No.
RHJ44804
Species reactivity
Human, Mouse, Rabbit
Host species
Mouse
Isotype
IgG2b
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
P2RX7, Purinergic receptor, P2X purinoceptor 7, P2X7, P2Z receptor, ATP receptor
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q99572
Applications
ELISA, FCM, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3V98
CRISP3-PSP94 complex regulates P2RX7 mediated signalling in prostate cancer cells and macrophages via CITED2., PMID:40473221
Impaired LPS Signaling in Macrophages Overexpressing the P2X7 C-Terminal Domain or Anti-P2X7 C-Terminal Domain Intrabody., PMID:39940947
The Anti-Human P2X7 Monoclonal Antibody (Clone L4) Can Mediate Complement-Dependent Cytotoxicity of Human Leukocytes., PMID:39853757
ATP-P2X7R pathway activation limits the Tfh cell compartment during pediatric RSV infection., PMID:39044830
Increased concentrations of P2X7R in oligodendrocyte derived extracellular vesicles of Multiple sclerosis patients., PMID:38996986
The P2X7 Receptor is a Master Regulator of Microparticle and Mitochondria Exchange in Mouse Microglia., PMID:38984997
Oxidized ATP Suppresses B Lymphocyte Activity to Attenuate Antibody-mediated Rejection of Kidney Allografts in Mice., PMID:38946027
The purinergic receptor P2X7 as a modulator of viral vector-mediated antigen cross-presentation., PMID:38711513
Preconditioning-Induced Facilitation of Lactate Release from Astrocytes Is Essential for Brain Ischemic Tolerance., PMID:38604775
Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety., PMID:38395698
A Species-Specific Anti-Human P2X7 Monoclonal Antibody Reduces Graft-versus-Host Disease in Humanised Mice., PMID:37765233
Soybean lectin-triggered IL-6 secretion induces autophagy to kill intracellular mycobacteria through P2RX7 dependent activation of the JAK2/STAT3/Mcl-1 pathway., PMID:37716189
Animal Models for the Investigation of P2X7 Receptors., PMID:37175933
Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system-No evidence for the role of neuronal P2X7 receptors in colitis., PMID:36634819
Origin, distribution, and function of three frequent coding polymorphisms in the gene for the human P2X7 ion channel., PMID:36467077
NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload., PMID:36440584
Inflammasome Activity in Response to Influenza Vaccination Is Maintained in Monocyte-Derived Peripheral Blood Macrophages in Older Adults., PMID:35822051
Preparation of the Murine Anti-Human P2X7 Receptor Monoclonal Antibody (Clone L4)., PMID:35776321
Maternal P2X7 receptor inhibition prevents autism-like phenotype in male mouse offspring through the NLRP3-IL-1β pathway., PMID:35065198
Identification of Follicular T Cells in the Gut., PMID:34802124
The P2X7 purinergic receptor in intervertebral disc degeneration., PMID:34668208
A Methodological Approach Using rAAV Vectors Encoding Nanobody-Based Biologics to Evaluate ARTC2.2 and P2X7 In Vivo., PMID:34489954
The P2X7 Receptor: A Promising Pharmacological Target in Diabetic Retinopathy., PMID:34281162
Confocal Blood Flow Videomicroscopy of Thrombus Formation over Human Arteries and Local Targeting of P2X7., PMID:33920051
Immunohistochemical evidence of P2X7R, P2X4R and CaMKK2 in pyramidal neurons of frontal cortex does not align with Alzheimer's disease., PMID:33838119
A P2rx7 Passenger Mutation Affects the Vitality and Function of T cells in Congenic Mice., PMID:33336163
Purinergic Signaling in Pancreas-From Physiology to Therapeutic Strategies in Pancreatic Cancer., PMID:33233631
Inhibition of purinergic P2X receptor 7 (P2X7R) decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in U251 glioblastoma cells., PMID:32908225
Long-lived T follicular helper cells retain plasticity and help sustain humoral immunity., PMID:32144185
Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP., PMID:32049051
Production, characterization, and application of a monoclonal antibody specific for the extracellular domain of human P2X7R., PMID:31930453
Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity., PMID:31699796
Role of the P2X7 receptor in in vitro and in vivo glioma tumor growth., PMID:31448051
Activation of P2X7R- NLRP3 pathway in Retinal microglia contribute to Retinal Ganglion Cells death in chronic ocular hypertension (COH)., PMID:31445901
Enrichment of intestinal Lactobacillus by enhanced secretory IgA coating alters glucose homeostasis in P2rx7-/- mice., PMID:31249344
MiR-187-3p mimic alleviates ischemia-reperfusion-induced pain hypersensitivity through inhibiting spinal P2X7R and subsequent mature IL-1β release in mice., PMID:31100367
Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7., PMID:31035433
Amyloid β-dependent mitochondrial toxicity in mouse microglia requires P2X7 receptor expression and is prevented by nimodipine., PMID:31019207
P2X7-mediated ATP secretion is accompanied by depletion of cytosolic ATP., PMID:31016551
P2RX7 Deletion in T Cells Promotes Autoimmune Arthritis by Unleashing the Tfh Cell Response., PMID:30949163
P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus., PMID:30655308
ATP in the tumour microenvironment drives expression of nfP2X7, a key mediator of cancer cell survival., PMID:30087439
P2X7 receptor mediates NLRP3-dependent IL-1β secretion and parasite proliferation in Toxoplasma gondii-infected human small intestinal epithelial cells., PMID:29291748
Neuronal P2X7 Receptors Revisited: Do They Really Exist?, PMID:28747388
T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP., PMID:28297661
A phase I clinical trial demonstrates that nfP2X7 -targeted antibodies provide a novel, safe and tolerable topical therapy for basal cell carcinoma., PMID:28150889
Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation., PMID:27881823
P2X7 nucleotide receptor signaling potentiates the Wnt/β-catenin pathway in cells of the osteoblast lineage., PMID:27206526
Single Nucleotide Polymorphisms in P2X7 Gene Are Associated with Serum Immunoglobulin G Responses to Mycobacterium tuberculosis in Tuberculosis Patients., PMID:26798189
Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice., PMID:26529046