Catalog No.
RHJ43503
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IHC: 1:200-1:1000
Target
NOTCH4, INT3, hNotch4, Neurogenic locus notch homolog protein 4, Notch 4
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q99466
Applications
ELISA, FCM, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3V91
Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium., PMID:38984877
The Clinical Application of Immunohistochemical Expression of Notch4 Protein in Patients with Colon Adenocarcinoma., PMID:37108670
Circulating Tumor DNA Identifies Diverse Landscape of Acquired Resistance to Anti-Epidermal Growth Factor Receptor Therapy in Metastatic Colorectal Cancer., PMID:36007218
A common IL-4 receptor variant promotes asthma severity via a Treg cell GRB2-IL-6-Notch4 circuit., PMID:35841382
Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections., PMID:33915108
Hematological and Genetic Markers in the Rational Approach to Patients With HCV Sustained Virological Response With or Without Persisting Cryoglobulinemic Vasculitis., PMID:33721342
Precision medicine for human cancers with Notch signaling dysregulation (Review)., PMID:31894255
Quartz crystal microbalance biosensor for label-free MDA MB 231 cancer cell detection via notch-4 receptor., PMID:31357373
Associations of Multiple NOTCH4 Exonic Variants with Systemic Sclerosis., PMID:30442821
Alterations of Notch pathway in patients with adenoid cystic carcinoma of the trachea and its impact on survival., PMID:29858025
A Jagged 1-Notch 4 molecular switch mediates airway inflammation induced by ultrafine particles., PMID:29627423
Delta-like Ligand-4-Notch Signaling Inhibition Regulates Pancreatic Islet Function and Insulin Secretion., PMID:29386132
Notch Ligand Binding Assay Using Flow Cytometry., PMID:29333477
Short Pulse of Clinical Concentration of Bevacizumab Modulates Human Retinal Pigment Epithelial Functionality., PMID:26975025
Notch signaling mediates crosstalk between endothelial cells and macrophages via Dll4 and IL6 in cardiac microvascular inflammation., PMID:26826491
Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β., PMID:26646450
Cripto-1 as a novel therapeutic target for triple negative breast cancer., PMID:26059540
Endothelial Jagged1 antagonizes Dll4 regulation of endothelial branching and promotes vascular maturation downstream of Dll4/Notch1., PMID:25767274
Clinicopathological significance of aberrant Notch receptors in intrahepatic cholangiocarcinoma., PMID:25031748
Genome-wide association study of hepatitis C virus- and cryoglobulin-related vasculitis., PMID:25030430
Nicastrin and Notch4 drive endocrine therapy resistance and epithelial to mesenchymal transition in MCF7 breast cancer cells., PMID:24919951
Notch1 and 4 signaling responds to an increasing vascular wall shear stress in a rat model of arteriovenous malformations., PMID:24563863
The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors., PMID:24145721
Implications of Dll4-Notch signaling activation in primary glioblastoma multiforme., PMID:23787764
Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4)., PMID:23675950
Expression of immune genes on chromosome 6p21.3-22.1 in schizophrenia., PMID:23395714
Loss of CCM3 impairs DLL4-Notch signalling: implication in endothelial angiogenesis and in inherited cerebral cavernous malformations., PMID:23388056
Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy., PMID:22829975
Expression of Notch receptors and ligands on immature and mature T cells., PMID:22310713
Regulation of experimental autoimmune uveoretinitis by anti-delta-like ligand 4 monoclonal antibody., PMID:21896864
Modulation of endothelial cell network formation in vitro by molecular signaling of head and neck squamous cell carcinoma (HNSCC) exposed to cetuximab., PMID:21820450
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy., PMID:21779181
Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus., PMID:20662065
Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors., PMID:20161710
A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma., PMID:20069356
Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease., PMID:19546852
Human umbilical cord epithelial cells express Notch1: implications for its epidermal-like differentiation., PMID:17851046
Venous identity is lost but arterial identity is not gained during vein graft adaptation., PMID:17463332
Immunohistological localization of Notch receptors and their ligands Delta and Jagged in synovial tissues of rheumatoid arthritis., PMID:16307184
Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells., PMID:15535842
Notch4 inhibits endothelial apoptosis via RBP-Jkappa-dependent and -independent pathways., PMID:14701863
Induction of Notch signaling by tumor necrosis factor in rheumatoid synovial fibroblasts., PMID:14586405
A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling., PMID:12482954
Cortisol regulates the expression of Notch in osteoblasts., PMID:11948681
Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation., PMID:11909975
Expression of notch homologues in the synovium of rheumatoid arthritis and osteoarthritis patients., PMID:11678296
Interactions between fibroblast growth factors and Notch regulate neuronal differentiation., PMID:11466430
For research use only. Not for human or drug use.
