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Anti-NOTCH4 Antibody (R3V91)

Catalog #:   RHJ43503 Specific References (47) DATASHEET
Host species: Mouse
Isotype: IgG2a
Applications: ELISA, FCM, IHC
Accession: Q99466
Overview

Catalog No.

RHJ43503

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a

Clonality

Monoclonal

Tested applications

ELISA: 1:10000, FCM: 1:200-1:400, IHC: 1:200-1:1000

Target

NOTCH4, INT3, hNotch4, Neurogenic locus notch homolog protein 4, Notch 4

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q99466

Applications

ELISA, FCM, IHC

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3V91

Data Image
  • Flow Cytometry
    Flow cytometric analysis of Hela cells using NOTCH4 mouse mAb (green) and negative control (red).
  • Immunohistochemical
    Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using NOTCH4 mouse mAb with DAB staining.
  • Immunohistochemical
    Immunohistochemical analysis of paraffin-embedded human breast cancer tissues using NOTCH4 mouse mAb with DAB staining.
References

Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium., PMID:38984877

The Clinical Application of Immunohistochemical Expression of Notch4 Protein in Patients with Colon Adenocarcinoma., PMID:37108670

Circulating Tumor DNA Identifies Diverse Landscape of Acquired Resistance to Anti-Epidermal Growth Factor Receptor Therapy in Metastatic Colorectal Cancer., PMID:36007218

A common IL-4 receptor variant promotes asthma severity via a Treg cell GRB2-IL-6-Notch4 circuit., PMID:35841382

Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections., PMID:33915108

Hematological and Genetic Markers in the Rational Approach to Patients With HCV Sustained Virological Response With or Without Persisting Cryoglobulinemic Vasculitis., PMID:33721342

Precision medicine for human cancers with Notch signaling dysregulation (Review)., PMID:31894255

Quartz crystal microbalance biosensor for label-free MDA MB 231 cancer cell detection via notch-4 receptor., PMID:31357373

Associations of Multiple NOTCH4 Exonic Variants with Systemic Sclerosis., PMID:30442821

Alterations of Notch pathway in patients with adenoid cystic carcinoma of the trachea and its impact on survival., PMID:29858025

A Jagged 1-Notch 4 molecular switch mediates airway inflammation induced by ultrafine particles., PMID:29627423

Delta-like Ligand-4-Notch Signaling Inhibition Regulates Pancreatic Islet Function and Insulin Secretion., PMID:29386132

Notch Ligand Binding Assay Using Flow Cytometry., PMID:29333477

Short Pulse of Clinical Concentration of Bevacizumab Modulates Human Retinal Pigment Epithelial Functionality., PMID:26975025

Notch signaling mediates crosstalk between endothelial cells and macrophages via Dll4 and IL6 in cardiac microvascular inflammation., PMID:26826491

Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β., PMID:26646450

Cripto-1 as a novel therapeutic target for triple negative breast cancer., PMID:26059540

Endothelial Jagged1 antagonizes Dll4 regulation of endothelial branching and promotes vascular maturation downstream of Dll4/Notch1., PMID:25767274

Clinicopathological significance of aberrant Notch receptors in intrahepatic cholangiocarcinoma., PMID:25031748

Genome-wide association study of hepatitis C virus- and cryoglobulin-related vasculitis., PMID:25030430

Nicastrin and Notch4 drive endocrine therapy resistance and epithelial to mesenchymal transition in MCF7 breast cancer cells., PMID:24919951

Notch1 and 4 signaling responds to an increasing vascular wall shear stress in a rat model of arteriovenous malformations., PMID:24563863

The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors., PMID:24145721

Implications of Dll4-Notch signaling activation in primary glioblastoma multiforme., PMID:23787764

Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4)., PMID:23675950

Expression of immune genes on chromosome 6p21.3-22.1 in schizophrenia., PMID:23395714

Loss of CCM3 impairs DLL4-Notch signalling: implication in endothelial angiogenesis and in inherited cerebral cavernous malformations., PMID:23388056

Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy., PMID:22829975

Expression of Notch receptors and ligands on immature and mature T cells., PMID:22310713

Regulation of experimental autoimmune uveoretinitis by anti-delta-like ligand 4 monoclonal antibody., PMID:21896864

Modulation of endothelial cell network formation in vitro by molecular signaling of head and neck squamous cell carcinoma (HNSCC) exposed to cetuximab., PMID:21820450

Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy., PMID:21779181

Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus., PMID:20662065

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors., PMID:20161710

A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma., PMID:20069356

Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease., PMID:19546852

Human umbilical cord epithelial cells express Notch1: implications for its epidermal-like differentiation., PMID:17851046

Venous identity is lost but arterial identity is not gained during vein graft adaptation., PMID:17463332

Immunohistological localization of Notch receptors and their ligands Delta and Jagged in synovial tissues of rheumatoid arthritis., PMID:16307184

Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells., PMID:15535842

Notch4 inhibits endothelial apoptosis via RBP-Jkappa-dependent and -independent pathways., PMID:14701863

Induction of Notch signaling by tumor necrosis factor in rheumatoid synovial fibroblasts., PMID:14586405

A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling., PMID:12482954

Cortisol regulates the expression of Notch in osteoblasts., PMID:11948681

Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation., PMID:11909975

Expression of notch homologues in the synovium of rheumatoid arthritis and osteoarthritis patients., PMID:11678296

Interactions between fibroblast growth factors and Notch regulate neuronal differentiation., PMID:11466430

Datasheet

Document Download

Anti-NOTCH4 Antibody (R3V91).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

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Anti-NOTCH4 Antibody (R3V91) [RHJ43503]
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