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Anti-KAT5/TIP60 Antibody (R3V66)

Catalog #:   RHJ35401 Specific References (32) DATASHEET
Host species: Mouse
Isotype: IgG2b
Applications: IHC
Accession: Q92993
Overview

Catalog No.

RHJ35401

Species reactivity

Human

Host species

Mouse

Isotype

IgG2b

Clonality

Monoclonal

Tested applications

IHC: 1:200-1:1000

Target

Tip60, cPLA(2)-interacting protein, Histone acetyltransferase KAT5, 60 kDa Tat-interactive protein, KAT5, Lysine acetyltransferase 5, HTATIP, TIP60, HIV-1 Tat interactive protein, Histone acetyltransferase HTATIP

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q92993

Applications

IHC

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3V66

Data Image
  • Immunohistochemical
    Immunohistochemical analysis of paraffin-embedded human liver carcinoma (A), recturn carcinoma (B), normal medulla tissue (C) and normal interbrain tissues (D), showing nuclear localization using Tip60 mouse mAb with DAB staining.
References

Positive coactivator PC4 shows dynamic nucleolar distribution required for rDNA transcription and protein synthesis., PMID:40517275

3, 3'-diindolylmethane, a natural aryl hydrocarbon receptor agonist, alleviates ulcerative colitis by enhancing "glycolysis-lactate-STAT3″ and TIP60 signals-mediated Treg differentiation., PMID:37793204

The involvement of high succinylation modification in the development of prostate cancer., PMID:36387072

Protein succinylation associated with the progress of hepatocellular carcinoma., PMID:36308411

Regulation of UHRF1 acetylation by TIP60 is important for colon cancer cell proliferation., PMID:35951156

The Protective Effects of KAT5 Inhibition on Ocular Inflammation by Mediating the PI3K/AKT Pathway in a Murine Model of Allergic Conjunctivitis., PMID:35503228

Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets., PMID:34077757

FosB recruits KAT5 to potentiate the growth and metastasis of papillary thyroid cancer in a DPP4-dependent manner., PMID:32891613

Tip60 and p300 function antagonistically in the epigenetic regulation of HPV18 E6/E7 genes in cervical cancer HeLa cells., PMID:32399935

TIP60-dependent acetylation of the SPZ1-TWIST complex promotes epithelial-mesenchymal transition and metastasis in liver cancer., PMID:30154425

Ethanol-induced modulation of GPR55 expression in human monocyte-derived dendritic cells is accompanied by H4K12 acetylation., PMID:29957399

Targeting histone-acetyltransferase Tat-interactive protein 60 inhibits intestinal allergy., PMID:28871603

Functional Characterization of ATM Kinase Using Acetylation-Specific Antibodies., PMID:28477118

Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3+ T-regulatory Cell Function and Promotes Antitumor Immunity., PMID:27769803

Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation., PMID:26829474

Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-κB pathway., PMID:26464124

Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer., PMID:24525235

Visualization and quantification of APP intracellular domain-mediated nuclear signaling by bimolecular fluorescence complementation., PMID:24086696

Lysosome-dependent p300/FOXP3 degradation and limits Treg cell functions and enhances targeted therapy against cancers., PMID:23644046

Stabilization of p21 (Cip1/WAF1) following Tip60-dependent acetylation is required for p21-mediated DNA damage response., PMID:23238566

SIAH-mediated ubiquitination and degradation of acetyl-transferases regulate the p53 response and protein acetylation., PMID:23044042

HIV-1 Tat impairs cell cycle control by targeting the Tip60, Plk1 and cyclin B1 ternary complex., PMID:22391203

Tip60-mediated acetylation activates transcription independent apoptotic activity of Abl., PMID:21781306

MRG15 activates the cdc2 promoter via histone acetylation in human cells., PMID:21324423

PDCD5 interacts with Tip60 and functions as a cooperator in acetyltransferase activity and DNA damage-induced apoptosis., PMID:19308289

The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein., PMID:19176879

Stability of Nmi protein is controlled by its association with Tip60., PMID:17406968

A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein., PMID:16103124

Expression and function of androgen receptor coactivators in prostate cancer., PMID:15663989

von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity., PMID:15502158

Expression of Tip60, an androgen receptor coactivator, and its role in prostate cancer development., PMID:12717424

PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production., PMID:11416127

Datasheet
$ 220
Product specifications
50 μg 220 100 μg 350

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For research use only. Not for human or drug use.

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Anti-KAT5/TIP60 Antibody (R3V66) [RHJ35401]
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