Catalog No.
RHJ35401
Species reactivity
Human
Host species
Mouse
Isotype
IgG2b
Clonality
Monoclonal
Tested applications
IHC: 1:200-1:1000
Target
Tip60, cPLA(2)-interacting protein, Histone acetyltransferase KAT5, 60 kDa Tat-interactive protein, KAT5, Lysine acetyltransferase 5, HTATIP, TIP60, HIV-1 Tat interactive protein, Histone acetyltransferase HTATIP
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q92993
Applications
IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3V66
Positive coactivator PC4 shows dynamic nucleolar distribution required for rDNA transcription and protein synthesis., PMID:40517275
3, 3'-diindolylmethane, a natural aryl hydrocarbon receptor agonist, alleviates ulcerative colitis by enhancing "glycolysis-lactate-STAT3″ and TIP60 signals-mediated Treg differentiation., PMID:37793204
The involvement of high succinylation modification in the development of prostate cancer., PMID:36387072
Protein succinylation associated with the progress of hepatocellular carcinoma., PMID:36308411
Regulation of UHRF1 acetylation by TIP60 is important for colon cancer cell proliferation., PMID:35951156
The Protective Effects of KAT5 Inhibition on Ocular Inflammation by Mediating the PI3K/AKT Pathway in a Murine Model of Allergic Conjunctivitis., PMID:35503228
Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets., PMID:34077757
FosB recruits KAT5 to potentiate the growth and metastasis of papillary thyroid cancer in a DPP4-dependent manner., PMID:32891613
Tip60 and p300 function antagonistically in the epigenetic regulation of HPV18 E6/E7 genes in cervical cancer HeLa cells., PMID:32399935
TIP60-dependent acetylation of the SPZ1-TWIST complex promotes epithelial-mesenchymal transition and metastasis in liver cancer., PMID:30154425
Ethanol-induced modulation of GPR55 expression in human monocyte-derived dendritic cells is accompanied by H4K12 acetylation., PMID:29957399
Targeting histone-acetyltransferase Tat-interactive protein 60 inhibits intestinal allergy., PMID:28871603
Functional Characterization of ATM Kinase Using Acetylation-Specific Antibodies., PMID:28477118
Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3+ T-regulatory Cell Function and Promotes Antitumor Immunity., PMID:27769803
Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation., PMID:26829474
Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-κB pathway., PMID:26464124
Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer., PMID:24525235
Visualization and quantification of APP intracellular domain-mediated nuclear signaling by bimolecular fluorescence complementation., PMID:24086696
Lysosome-dependent p300/FOXP3 degradation and limits Treg cell functions and enhances targeted therapy against cancers., PMID:23644046
Stabilization of p21 (Cip1/WAF1) following Tip60-dependent acetylation is required for p21-mediated DNA damage response., PMID:23238566
SIAH-mediated ubiquitination and degradation of acetyl-transferases regulate the p53 response and protein acetylation., PMID:23044042
HIV-1 Tat impairs cell cycle control by targeting the Tip60, Plk1 and cyclin B1 ternary complex., PMID:22391203
Tip60-mediated acetylation activates transcription independent apoptotic activity of Abl., PMID:21781306
MRG15 activates the cdc2 promoter via histone acetylation in human cells., PMID:21324423
PDCD5 interacts with Tip60 and functions as a cooperator in acetyltransferase activity and DNA damage-induced apoptosis., PMID:19308289
The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein., PMID:19176879
Stability of Nmi protein is controlled by its association with Tip60., PMID:17406968
A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein., PMID:16103124
Expression and function of androgen receptor coactivators in prostate cancer., PMID:15663989
von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity., PMID:15502158
Expression of Tip60, an androgen receptor coactivator, and its role in prostate cancer development., PMID:12717424
PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production., PMID:11416127
For research use only. Not for human or drug use.
