Catalog No.
RHJ29702
Species reactivity
Human, Mouse, Rat, Monkey
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000, IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
SLP65, SLP-65, B-cell adapter containing a SH2 domain protein, Src homology 2 domain-containing leukocyte protein of 65 kDa, BASH, Cytoplasmic adapter protein, B-cell adapter containing a Src homology 2 domain protein, BLNK, B-cell linker protein
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q8WV28
Applications
ELISA, FCM, IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3V51
Effect of DNA methylation on inhibitor development in people with hemophilia A treated with FVIII concentrates., PMID:40502981
Integrative miRNA-mRNA profiling uncovers mechanisms of belimumab action in systemic lupus erythematosus., PMID:40160819
Novel components in the nuclear factor-kappa B (NF-κB) signaling pathways of endothelial cells under hyperglycemic-ischemic conditions., PMID:38854657
Altered Expression of B Cell Receptor Signaling Pathway Genes in Peripheral Blood of Patients with Multiple Sclerosis., PMID:38822513
Astragalus polysaccharides ameliorates experimental colitis by regulating memory B cells metabolism., PMID:38522565
Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between IgG sialylation and pDC functions., PMID:37010728
Luxeptinib interferes with LYN-mediated activation of SYK and modulates BCR signaling in lymphoma., PMID:36888611
B cell receptor ligation induces IgE plasma cell elimination., PMID:36880536
Regulation of B cell receptor signalling by Epstein-Barr virus nuclear antigens., PMID:36383217
Impact of sleep restriction in B-1 cells activation and differentiation., PMID:36179431
ErbB2/Her2-dependent downregulation of a cell death-promoting protein BLNK in breast cancer cells is required for 3D breast tumor growth., PMID:35933456
Non-Muscle Myosin II Is Essential for the Negative Regulation of B-Cell Receptor Signaling and B-Cell Activation., PMID:35493485
Peripheral B-cell dysregulation is associated with relapse after long-term quiescence in patients with multiple sclerosis., PMID:35416319
The Small GTPase RHOA Links SLP65 Activation to PTEN Function in Pre B Cells and Is Essential for the Generation and Survival of Normal and Malignant B Cells., PMID:35371049
Kinetics of Parasite-Specific Antibody and B-Cell-Associated Gene Expression in Brown Trout, Salmo trutta during Proliferative Kidney Disease., PMID:34943159
Lymphoid blast transformation in an MPN with BCR-JAK2 treated with ruxolitinib: putative mechanisms of resistance., PMID:34505882
The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration., PMID:34157287
Possible effects of chemokine-like factor-like MARVEL transmembrane domain-containing family on antiphospholipid syndrome., PMID:33813507
The unbalanced p53/SIRT1 axis may impact lymphocyte homeostasis in COVID-19 patients., PMID:33578018
Inhibition of B-cell receptor signaling disrupts cell adhesion in mantle cell lymphoma via RAC2., PMID:33570628
Abnormal thymic B cell activation and impaired T cell differentiation in pristane-induced lupus mice., PMID:33428991
A biophysical and structural analysis of the interaction of BLNK with 14-3-3 proteins., PMID:33176192
Rewiring of B cell receptor signaling by Epstein-Barr virus LMP2A., PMID:33020271
Identification of BLNK and BTK as mediators of rituximab-induced programmed cell death by CRISPR screens in GCB-subtype diffuse large B-cell lymphoma., PMID:32585766
Lamprey VLRB participates in pathogen detection, VLRB/L-BLNK/L-NF-κB (B-like cells) signal transduction, and development., PMID:32512043
Integrated transcriptomic correlation network analysis identifies COPD molecular determinants., PMID:32099002
Effects of Cell Differentiation on the Phagocytic Activities of IgM+ B Cells in a Teleost Fish., PMID:31608055
Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter's syndrome: therapeutic implications., PMID:31467429
Distinct roles of BCNP1 in B-cell development and activation., PMID:31412363
Deregulation of Ikaros expression in B-1 cells: New insights in the malignant transformation to chronic lymphocytic leukemia., PMID:31299112
[Structure and function of B-cell linker and its role in the development of B cell-related diseases]., PMID:30890517
The B cell novel protein 1 (BCNP1) regulates BCR signaling and B cell apoptosis., PMID:30888050
B cells in chronic graft-versus-host disease., PMID:30849450
Hypomorphic Mutations in the BCR Signalosome Lead to Selective Immunoglobulin M Deficiency and Impaired B-cell Homeostasis., PMID:30619340
Simulation of the Dynamics of Primary Immunodeficiencies in B Cells., PMID:30116248
Profiling the origin, dynamics, and function of traction force in B cell activation., PMID:30087179
An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD., PMID:28851699
Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival., PMID:28369050
Constitutive Phosphorylation of STAT3 by the CK2-BLNK-CD5 Complex., PMID:28130399
Regulation of B cell fate by chronic activity of the IgE B cell receptor., PMID:27935477
Autonomous membrane IgE signaling prevents IgE-memory formation., PMID:27428827
Identification and characterisation of the immune response properties of Lampetra japonica BLNK., PMID:27126461
PAX5 promotes pre-B cell proliferation by regulating the expression of pre-B cell receptor and its downstream signaling., PMID:27016671
RAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals., PMID:26834154
MAP4K Family Kinases in Immunity and Inflammation., PMID:26791862
ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway., PMID:26522721
Concomitant high expression of Toll-like receptor (TLR) and B-cell receptor (BCR) signalling molecules has clinical implications in mantle cell lymphoma., PMID:26354285
IRF4 Deficiency Leads to Altered BCR Signalling Revealed by Enhanced PI3K Pathway, Decreased SHIP Expression and Defected Cytoskeletal Responses., PMID:26173778
Differential expression of Toll-like receptor (TLR) and B cell receptor (BCR) signaling molecules in primary diffuse large B-cell lymphoma of the central nervous system., PMID:25391967
The autoinhibitory C-terminal SH2 domain of phospholipase C-γ2 stabilizes B cell receptor signalosome assembly., PMID:25227611
For research use only. Not for human or drug use.
