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Anti-CRTC2 Antibody (R3U85)

Catalog #:   RHH86802 Specific References (19) DATASHEET
Host species: Mouse
Isotype: IgG1
Applications: FCM, IF, IHC, WB
Accession: Q53ET0
Overview

Catalog No.

RHH86802

Species reactivity

Human, Monkey

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

FCM: 1:200-1:400, IF: 1:200-1:1000, IHC: 1:200-1:1000, WB: 1:500-1:2000

Target

CREB-regulated transcription coactivator 2, TORC-2, Transducer of CREB protein 2, CRTC2, Transducer of regulated cAMP response element-binding protein 2, TORC2

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q53ET0

Applications

FCM, IF, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3U85

Data Image
  • Flow Cytometry
    Flow cytometric analysis of Hela cells using CRTC2 mouse mAb (green) and negative control (purple).
  • Immunofluorescence
    Immunofluorescence analysis of Hela cells using CRTC2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
  • Immunohistochemical
    Immunohistochemical analysis of paraffin-embedded human ovary tumour tissues (left) and lung cancer (right) using CRTC2 mouse mAb with DAB staining.
  • Western blot
    Western blot analysis using CRTC2 mouse mAb against Hela (1) and HEK293 (2) cell lysate.
References

Effect of exercise and butyrate supplementation on microbiota composition and lipid metabolism., PMID:31454784

Transcription Factor STAT3 Serves as a Negative Regulator Controlling IgE Class Switching in Mice., PMID:31026806

Immunolocalisation of aromatase regulators liver kinase B1, phosphorylated AMP-activated protein kinase and cAMP response element-binding protein-regulated transcription co-activators in the human testis., PMID:26946412

CRTC2 activation in the suprachiasmatic nucleus, but not paraventricular nucleus, varies in a diurnal fashion and increases with nighttime light exposure., PMID:25080490

cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) promotes glucagon clearance and hepatic amino acid catabolism to regulate glucose homeostasis., PMID:23595987

Dual mTORC1/2 and HER2 blockade results in antitumor activity in preclinical models of breast cancer resistant to anti-HER2 therapy., PMID:22407832

Regulation of mast cell survival and function by tuberous sclerosis complex 1., PMID:22362037

Isolation of the mTOR complexes by affinity purification., PMID:22125060

mTOR activity under hypoxia., PMID:22125059

Evaluation of the nutrient-sensing mTOR pathway., PMID:22125058

PI3K/mTOR signaling regulates prostatic branching morphogenesis., PMID:22015718

CREB coactivator CRTC2/TORC2 and its regulator calcineurin crucially mediate follicle-stimulating hormone and transforming growth factor β1 upregulation of steroidogenesis., PMID:21826657

AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling., PMID:20864035

Raptor is phosphorylated by cdc2 during mitosis., PMID:20169205

Selective concomitant inhibition of mTORC1 and mTORC2 activity in estrogen receptor negative breast cancer cells by BN107 and oleanolic acid., PMID:20027631

mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action., PMID:20022946

Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer., PMID:20010869

High-throughput screening for mTORC1/mTORC2 kinase inhibitors using a chemiluminescence-based ELISA assay., PMID:19895344

Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein., PMID:19299511

Datasheet

Document Download

Anti-CRTC2 Antibody (R3U85).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

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Anti-CRTC2 Antibody (R3U85) [RHH86802]
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