Anti-PKN1 Antibody (R3U29)

Catalog No.

RHH26902

Species reactivity

Human

Host species

Mouse

Isotype

IgG2b

Clonality

Monoclonal

Tested applications

ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000, IHC: 1:200-1:1000

Target

Protein kinase C-like PKN, Serine/threonine-protein kinase N1, PRK1, Serine-threonine protein kinase N, PKN, Protease-activated kinase 1, PRKCL1, PKN1, Protein-kinase C-related kinase 1, PAK-1, Protein kinase PKN-alpha, PAK1, Protein kinase C-like 1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q16512

Applications

ELISA, FCM, IF, IHC

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3U29

PKN1 kinase-negative knock-in mice develop splenomegaly and leukopenia at advanced age without obvious autoimmune-like phenotypes., PMID:31562379

Cardiolipin activates antigen-presenting cells via TLR2-PI3K-PKN1-AKT/p38-NF-kB signaling to prime antigen-specific naïve T cells in mice., PMID:29313959

The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression., PMID:28875501

Co-immunoprecipitation of Plant Receptor Kinases., PMID:28567647

Seroprevalence of antibodies against Pkn1, a novel potential immunogen, in Chlamydia trachomatis-infected Macaca nemestrina and human patients., PMID:25032212

Protein kinases paralleling late-phase LTP formation in dorsal hippocampus in the rat., PMID:24911953

Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation., PMID:23223530

The interaction of PKN3 with RhoC promotes malignant growth., PMID:22217540

Infectivity of Leishmania mexicana is associated with differential expression of protein kinase C-like triggered during a cell-cell contact., PMID:19851504

Protein kinase C-related kinase 2 regulates hepatitis C virus RNA polymerase function by phosphorylation., PMID:15364941

Generation of a constitutively active fragment of PKN in microglia/macrophages after middle cerebral artery occlusion in rats., PMID:11723183

Phosphorylation of tau is regulated by PKN., PMID:11104762

Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase N., PMID:10924361

Induction of a 55-kDa PKN cleavage product by ischemia/reperfusion model in the rat retina., PMID:10634597

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2., PMID:10226025

A protein kinase, PKN, accumulates in Alzheimer neurofibrillary tangles and associated endoplasmic reticulum-derived vesicles and phosphorylates tau protein., PMID:9736660

PKN interacts with a paraneoplastic cerebellar degeneration-associated antigen, which is a potential transcription factor., PMID:9637778

PRK1 is targeted to endosomes by the small GTPase, RhoB., PMID:9478917

Leukocyte function-associated antigen 1-dependent adhesion of rat hepatoma AH66F cells and inhibition by protein kinase C inhibitors., PMID:9214694

Translocation of PKN from the cytosol to the nucleus induced by stresses., PMID:8816775

Monoclonal antibodies against nuclear casein kinase NII (PK-N2)., PMID:2076898

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Anti-PKN1 Antibody (R3U29).pdf