Catalog No.
RHH26001
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
IHC: 1:50-1:200
Target
Laminin-8 subunit alpha, Laminin-9 subunit alpha, Laminin-14 subunit alpha, Laminin subunit alpha-4, LAMA4
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q16363
Applications
IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3U27
Anti-Laminin β4 IgG Drives Tissue Damage in Anti-p200 Pemphigoid and Shows Interactions with Laminin α3 and γ1/2 Chains., PMID:39320300
CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4., PMID:34575887
Chromatin run-on sequencing analysis finds that ECM remodeling plays an important role in canine hemangiosarcoma pathogenesis., PMID:32571313
Flow-induced Reorganization of Laminin-integrin Networks Within the Endothelial Basement Membrane Uncovered by Proteomics., PMID:32332107
Laminin α4 contributes to airway remodeling and inflammation in asthma., PMID:31553662
Differential Regulation of T-cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node., PMID:31343575
Laminin α4 overexpression in the anterior lens capsule may contribute to the senescence of human lens epithelial cells in age-related cataract., PMID:31076560
MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome., PMID:26921326
Effect of Laminin-A4 inhibition on cluster formation of human osteoarthritic chondrocytes., PMID:26295200
Laminins 411 and 421 differentially promote tumor cell migration via α6β1 integrin and MCAM (CD146)., PMID:24951930
Monoclonal antibodies to human laminin α4 chain globular domain inhibit tumor cell adhesion and migration on laminins 411 and 421, and binding of α6β1 integrin and MCAM to α4-laminins., PMID:24681327
Platelets store laminins 411/421 and 511/521 in compartments distinct from α- or dense granules and secrete these proteins via microvesicles., PMID:24450402
Laminin isoforms in endothelial and perivascular basement membranes., PMID:23263631
Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS., PMID:22792325
Screening of integrin-binding peptides from the laminin α4 and α5 chain G domain peptide library., PMID:22391228
Suppression of lung cancer cell invasion and metastasis by connexin43 involves the secretion of follistatin-like 1 mediated via histone acetylation., PMID:21718795
Immigration check for neutrophils in RA lining: laminin alpha5 low expression regions act as exit points., PMID:20059371
Stromal laminin chain distribution in normal, hyperplastic and malignant oral mucosa: relation to myofibroblast occurrence and vessel formation., PMID:19889153
Basement membrane remodelling and segmental fibrosis in sporadic inclusion body myositis., PMID:19473842
LAMA4, highly expressed in human hepatocellular carcinoma from Chinese patients, is a novel marker of tumor invasion and metastasis., PMID:18084776
Cryptic fragment alpha4 LG4-5 derived from laminin alpha4 chain inhibits de novo adipogenesis by modulating the effect of fibroblast growth factor-2., PMID:18067585
Involvement of specific laminins and nidogens in the active remodeling of the basal lamina of labial salivary glands from patients with Sjögren's syndrome., PMID:17075843
Identification of an active site on the laminin alpha4 chain globular domain that binds to alphavbeta3 integrin and promotes angiogenesis., PMID:16824487
Rat glomerular mesangial cells require laminin-9 to migrate in response to insulin-like growth factor binding protein-5., PMID:16672690
Laminins 2 (alpha2beta1gamma1, Lm-211) and 8 (alpha4beta1gamma1, Lm-411) are synthesized and secreted by tooth pulp fibroblasts and differentially promote neurite outgrowth from trigeminal ganglion sensory neurons., PMID:15894315
An endothelial laminin isoform, laminin 8 (alpha4beta1gamma1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis., PMID:15172971
Localization of the laminin alpha4 chain in the skin and identification of a heparin-dependent cell adhesion site within the laminin alpha4 chain C-terminal LG4 module., PMID:15086543
The alpha4 laminin subunit regulates endothelial cell survival., PMID:14980521
Laminin isoforms in fetal and adult human adrenal cortex., PMID:14557481
Laminin-8/9 is synthesized by rat glomerular mesangial cells and is required for PDGF-induced mesangial cell migration., PMID:12787401
Complex interactions between the laminin alpha 4 subunit and integrins regulate endothelial cell behavior in vitro and angiogenesis in vivo., PMID:12454288
Localization of laminin alpha4-chain in developing and adult human tissues., PMID:12133914
Modification of the laminin alpha 4 chain by chondroitin sulfate attachment to its N-terminal domain., PMID:11557064
Laminin-2/4 from human placenta is a better adhesion agent for primary keratinocytes than laminin-1 from EHS sarcoma., PMID:11401326
Structure and function of a vimentin-associated matrix adhesion in endothelial cells., PMID:11160825
Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues., PMID:10934193
Laminin alpha4 and integrin alpha6 are upregulated in regenerating dy/dy skeletal muscle: comparative expression of laminin and integrin isoforms in muscles regenerating after crush injury., PMID:10772822
Erythromegakaryocytic cells synthesize laminin-8 (alpha4beta1gamma1)., PMID:10623479
Developmental expression and cellular origin of the laminin alpha2, alpha4, and alpha5 chains in the intestine., PMID:10364433
Differential expression of five laminin alpha (1-5) chains in developing and adult mouse kidney., PMID:9415429
For research use only. Not for human or drug use.
