Catalog No.
RHH14501
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400
Target
TRADD, TNFR1-associated DEATH domain protein, Tumor necrosis factor receptor type 1-associated DEATH domain protein, TNFRSF1A-associated via death domain
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q15628
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3T86
PeiTuQingXin formula alleviated atopic dermatitis symptoms via inhibiting TRADD/TRAF2/RIP1 complex mediated NF-κB signaling pathway activation., PMID:40056166
Effects of Aeromonas infection on the immune system, physical barriers and microflora structure in the intestine of juvenile grass carp (Ctenopharyngodon idella)., PMID:39059563
Molecular signatures in prion disease: altered death receptor pathways in a mouse model., PMID:38802941
Potential Molecular Mechanisms of Rare Anti-Tumor Immune Response by SARS-CoV-2 in Isolated Cases of Lymphomas., PMID:34696358
SNHG9, delivered by adipocyte-derived exosomes, alleviates inflammation and apoptosis of endothelial cells through suppressing TRADD expression., PMID:32007500
Downregulation of TNF-α/TNF-R1 Signals by AT-Lipoxin A4 May Be a Significant Mechanism of Attenuation in SAP-Associated Lung Injury., PMID:31097921
The small molecule NSM00191 specifically represses the TNF-α/NF-кB axis in foot and ankle rheumatoid arthritis., PMID:30416388
Increased expression of microRNA-338-3p contributes to production of Dsg3 antibody in pemphigus vulgaris patients., PMID:29749496
A novel synthetic analogue of ω-3 17,18-epoxyeicosatetraenoic acid activates TNF receptor-1/ASK1/JNK signaling to promote apoptosis in human breast cancer cells., PMID:28798154
MutY DNA Glycosylase Protects Cells From Tumor Necrosis Factor Alpha-Induced Necroptosis., PMID:28059467
TNF-α is involved in apoptosis triggered by grass carp reovirus infection in vitro., PMID:27346157
Evolutionarily conserved primary TNF sequences relate to its primitive functions in cell death induction., PMID:26729029
Renal microRNA- and RNA-profiles in progressive chronic kidney disease., PMID:26707063
GBM Derived Gangliosides Induce T Cell Apoptosis through Activation of the Caspase Cascade Involving Both the Extrinsic and the Intrinsic Pathway., PMID:26226135
Loss of tumor suppressive microRNA-31 enhances TRADD/NF-κB signaling in glioblastoma., PMID:26164206
Electrical conduction system apoptosis in type II diabetes mellitus., PMID:24398990
Agonist antibody activates death receptor 6 downstream signaling involving TRADD recruitment., PMID:24374337
Molecular profiling of acute and chronic rejections of renal allografts., PMID:24302958
Effect of infliximab combined with methylprednisolone on expressions of NF-κB, TRADD, and FADD in rat acute spinal cord injury., PMID:23574812
RIP1 expression is necessary for CD30-mediated cell death induction in anaplastic large-cell lymphoma cells., PMID:23545938
Ustekinumab improves psoriasis-related gene expression in noninvolved psoriatic skin without inhibition of the antimicrobial response., PMID:23278632
5-epi-Sinuleptolide induces cell cycle arrest and apoptosis through tumor necrosis factor/mitochondria-mediated caspase signaling pathway in human skin cancer cells., PMID:22348919
Critical role of the death receptor pathway in the antitumoral effects induced by hispanolone derivatives., PMID:22310289
TL1A and DR3, a TNF family ligand-receptor pair that promotes lymphocyte costimulation, mucosal hyperplasia, and autoimmune inflammation., PMID:22017439
Death signal transduction induced by co-immobilized TNF-α plus IFN-γ and the development of polymeric anti-cancer drugs., PMID:20832854
Altered expression of TNF-alpha signaling pathway proteins in systemic lupus erythematosus., PMID:20516030
Azadirachtin interacts with the tumor necrosis factor (TNF) binding domain of its receptors and inhibits TNF-induced biological responses., PMID:20018848
SYUNZ-16, a newly synthesized alkannin derivative, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of AKT/FOXO signal pathway., PMID:19904742
Decrease in tumor necrosis factor-alpha receptor-associated death domain results from ubiquitin-dependent degradation in obstructive renal injury in rats., PMID:19541932
TRAIL receptor mediates inflammatory cytokine release in an NF-kappaB-dependent manner., PMID:19434100
Tumor necrosis factor alpha induces gamma-glutamyltransferase expression via nuclear factor-kappaB in cooperation with Sp1., PMID:18996094
Immunomagnetic isolation of tumor necrosis factor receptosomes., PMID:18662566
Zfra is an inhibitor of Bcl-2 expression and cytochrome c release from the mitochondria., PMID:18403180
Epidermal growth factor (EGF) activates nuclear factor-kappaB through IkappaBalpha kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IkappaBalpha., PMID:17533369
Endotoxin preconditioning protects against the cytotoxic effects of TNFalpha after stroke: a novel role for TNFalpha in LPS-ischemic tolerance., PMID:17327883
Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma., PMID:16953224
Evidence of tumor necrosis factor receptor 1 signaling in human temporal lobe epilepsy., PMID:16919273
Regulatory mechanisms and functions of intermediate filaments: a study using site- and phosphorylation state-specific antibodies., PMID:16542212
Expression of antiapoptotic and proapoptotic molecules in diabetic retinas., PMID:16424911
Analysis of gene and protein expression during monocyte-macrophage differentiation and cholesterol loading--cDNA and protein array study., PMID:15910854
Surface calreticulin mediates muramyl dipeptide-induced apoptosis in RK13 cells., PMID:15817475
Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1., PMID:15629131
[Signal transduction and biological characteristics of EB virus-encoded latent membrane protein 1 and its correlation with CD40]., PMID:15562778
Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles., PMID:15357952
An autocrine/paracrine loop linking keratin 14 aggregates to tumor necrosis factor alpha-mediated cytotoxicity in a keratinocyte model of epidermolysis bullosa simplex., PMID:14660619
TL1A-induced NF-kappaB activation and c-IAP2 production prevent DR3-mediated apoptosis in TF-1 cells., PMID:12882979
IL-12 plays a significant role in the apoptosis of human T cells in the absence of antigenic stimulation., PMID:12242079
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice., PMID:11886269
Treatment with the pure antiestrogen faslodex (ICI 182780) induces tumor necrosis factor receptor 1 (TNFR1) expression in MCF-7 breast cancer cells., PMID:11110059
The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells., PMID:11032752
For research use only. Not for human or drug use.
