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Anti-SHH Antibody (R3T79)

Catalog #:   RHH10702 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG1
Applications: ELISA, FCM, IHC, WB
Accession: Q15465
Overview

Catalog No.

RHH10702

Species reactivity

Human, Mouse, Monkey

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

ELISA: 1:10000, FCM: 1:200-1:400, IHC: 1:200-1:1000, WB: 1:500-1:2000

Target

ShhNC, Sonic hedgehog protein, Shh N-terminal processed signaling domains, SHH, Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains, ShhN, ShhNp, HHG-1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q15465

Applications

ELISA, FCM, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3T79

Data Image
  • Flow Cytometry
    Flow cytometric analysis of HeLa cells using SHH mouse mAb (green) and negative control (red).
  • Immunohistochemical
    Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using SHH mouse mAb with DAB staining.
  • Western blot
    Western blot analysis using SHH mouse mAb against LNCaP (1), HepG2 (2), PANC-1 (3),HeLa (4), SK-N-SH (5), F9 (6), NIH3T3 (7), and COS7 (8) cell lysate.
References

SOX2 Expression and Regulation in Pulmonary Aplasia/Agenesis., PMID:40528275

Pathophysiological mechanisms of hair follicle regeneration and potential therapeutic strategies., PMID:40518544

Sonic hedgehog medulloblastomas are dependent on Netrin-1 for survival., PMID:40461501

Epidermal growth factor receptor specific immunotherapy for SHH medulloblastoma tested in an in vitro blood-brain barrier-model., PMID:40456204

A modular mRNA vaccine platform encoding antigen-presenting capsid virus-like particles enhances the immunogenicity of the malaria antigen Pfs25., PMID:40369344

Immunohistochemical detection of 5-hydroxymethylcytosine as a prognostic biomarker in non-WNT/Non-SHH medulloblastomas., PMID:40325038

Tumor-associated macrophages correlate with better outcome in SHH medulloblastoma., PMID:40303994

Differences in neuronal ciliation rate and ciliary content revealed by systematic imaging-based analysis of hiPSC-derived models across protocols., PMID:40292331

The Role of GREMLIN1, a Bone Morphogenetic Protein Antagonist, in Cancer Stem Cell Regulation., PMID:40277903

Molecular classification of medulloblastoma using immunohistochemistry: A single centre study., PMID:40056547

Sea Hare Hydrolysate Reduces PD-L1 Levels in Cancer Cells and Mitigates Rheumatoid Arthritis Ina Collagen-Induced Arthritis Mouse Model., PMID:39803276

Exome Sequencing of Chinese Patients With Anticitrullinated Protein Antibody-Positive Rheumatoid Arthritis in Singapore., PMID:39617413

Development of a ZRS Reporter System for the Newt (Cynops pyrrhogaster) During Terrestrial Limb Regeneration., PMID:39595071

Development and evaluation of two rapid lateral flow assays for on-site detection of African swine fever virus., PMID:39268541

Skin exposure to soil microbiota elicits changes in cell-mediated immunity to pneumococcal vaccine., PMID:39127736

Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response., PMID:39046874

Amivantamab plus Lazertinib in Previously Untreated EGFR-Mutated Advanced NSCLC., PMID:38924756

Development of a dual immunochromatographic test strip to detect E2 and Erns antibodies against classical swine fever., PMID:38666258

Incidence of Hyper Progressive Disease in Combination Immunotherapy and Anti-Programmed Cell Death Protein 1/Programmed Death-Ligand 1 Monotherapy for Unresectable Hepatocellular Carcinoma., PMID:38344443

Neutrophils and Neutrophil Extracellular Traps Cause Vascular Occlusion and Delayed Cerebral Ischemia After Subarachnoid Hemorrhage in Mice., PMID:38299355

MMP-2-mediated Scube2 degradation promotes blood-brain barrier disruption by blocking the interaction between astrocytes and endothelial cells via inhibiting Sonic hedgehog pathway during early cerebral ischemia., PMID:38148633

Preclinical Evaluation of the FGFR-Family Inhibitor Futibatinib for Pediatric Rhabdomyosarcoma., PMID:37627061

Phase I/II trial of a peptide-based COVID-19 T-cell activator in patients with B-cell deficiency., PMID:37596280

Myelin barrier breakdown, mechanical hypersensitivity, and painfulness in polyneuropathy with claudin-12 deficiency., PMID:37527762

Immunohistochemical Surrogates for Molecular Stratification in Medulloblastoma., PMID:37471625

Brain and Spinal Cord Tumors of Embryonic Origin., PMID:37452947

Expression Pattern of Sonic Hedgehog, Patched and Smoothened in Clear Cell Renal Carcinoma., PMID:37240278

SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches., PMID:37142671

[Study on in vitro differentiation of human adenoid-derived mesenchymal stem cells into olfactory sensory neurons]., PMID:36878502

Bothrops (Fer-de-lance) snakebites in the French departments of the Americas (Martinique and Guyana): Clinical and experimental studies and treatment by immunotherapy., PMID:36854042

Clinicomorphological and molecular analysis of medulloblastoma and association with survival: A single tertiary care center experience., PMID:38384024

Aryloxypropanolamine targets amyloid aggregates and reverses Alzheimer-like phenotypes in Alzheimer mouse models., PMID:36443837

CD155 is a putative therapeutic target in medulloblastoma., PMID:36301489

Selective targeting BMP2 and 4 in SMAD4 negative esophageal adenocarcinoma inhibits tumor growth and aggressiveness in preclinical models., PMID:35902550

Tumor-Associated Macrophages Correlate With Prognosis in Medulloblastoma., PMID:35860588

Role of GDF15/MAPK14 Axis in Chondrocyte Senescence as a Novel Senomorphic Agent in Osteoarthritis., PMID:35806043

Epigenomic Analysis Reveals the KCNK9 Potassium Channel as a Potential Therapeutic Target for Adenomyosis., PMID:35682653

LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants., PMID:35568025

Aniridia-related keratopathy relevant cell signaling pathways in human fetal corneas., PMID:35551459

Circulating neurofilament light chain as a promising biomarker of AAV-induced dorsal root ganglia toxicity in nonclinical toxicology species., PMID:35505662

Health-related quality-of-life outcomes in patients with advanced renal cell carcinoma treated with lenvatinib plus pembrolizumab or everolimus versus sunitinib (CLEAR): a randomised, phase 3 study., PMID:35489363

Detailed analysis of antibody responses to SARS-CoV-2 vaccination and infection in macaques., PMID:35404959

B Cell Depletion and SARS-CoV-2 Vaccine Responses in Neuroimmunologic Patients., PMID:35067959

Insulin Downregulated the Infection of Uropathogenic Escherichia coli (UPEC) in Bladder Cells in a High-Glucose Environment through JAK/STAT Signaling Pathway., PMID:34946023

Macaque-human differences in SARS-CoV-2 Spike antibody response elicited by vaccination or infection., PMID:34909774

Medulloblastoma: Clinicopathological Correlates of SHH, WNT, and Non-WNT/SHH Molecular Subgroups Analysis and Prognostic Significance: Mono-Institutional Series., PMID:34751426

An H3F3A K27M-mutation in a sonic hedgehog medulloblastoma., PMID:34747078

SHH Expression Is Significantly Associated With Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma., PMID:34732409

Possible interplay between estrogen and the BAFF may modify thyroid activity in Graves' disease., PMID:34725405

Myelin Oligodendrocyte Glycoprotein-Immunoglobulin G in the CSF: Clinical Implication of Testing and Association With Disability., PMID:34711644

Datasheet

Document Download

Anti-SHH Antibody (R3T79).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

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Anti-SHH Antibody (R3T79) [RHH10702]
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