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Anti-SETDB1 Antibody (R3T51)

Catalog #:   RHG99501 Specific References (15) DATASHEET
Host species: Mouse
Isotype: IgG1
Applications: IF, WB
Accession: Q15047
Overview

Catalog No.

RHG99501

Species reactivity

Human, Mouse, Monkey

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

IF: 1:200-1:1000, WB: 1:500-1:2000

Target

H3-K9-HMTase 4, ESET, SETDB1, SET domain bifurcated 1, Histone H3-K9 methyltransferase 4, KMT1E, KIAA0067, Lysine N-methyltransferase 1E, ERG-associated protein with SET domain, Histone-lysine N-methyltransferase SETDB1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q15047

Applications

IF, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3T51

Data Image
  • Immunofluorescence
    Immunofluorescence analysis of LOVO cells using SETDB1 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
  • Western blot
    Western blot analysis using SETDB1 mouse mAb against MCF-7 (1),T47D (2), HEK293 (3), JURKAT (4), NIH/3T3 (5), F9 (6), RAW246.7 (7) and Cos7 (8) cell lysate.
References

H3K14ac facilitates the reinstallation of constitutive heterochromatin in Drosophila early embryos by engaging Eggless/SetDB1., PMID:39437264

Genome-Wide CRISPR/Cas9 Screening Unveils a Novel Target ATF7IP-SETDB1 Complex for Enhancing Difficult-to-Express Protein Production., PMID:38240694

SETDB1-mediated CD147-K71 di-methylation promotes cell apoptosis in non-small cell lung cancer., PMID:37692516

Targeting intracellular proteins with cell type-specific functions for cancer immunotherapy., PMID:39872303

Nuclear AREG affects a low-proliferative phenotype and contributes to drug resistance of melanoma., PMID:36054710

Epigenetic comparison of CHO hosts and clones reveals divergent methylation and transcription patterns across lineages., PMID:35028935

Immunochemical Detection of Modified Cytosine Species in Mammalian Preimplantation Embryos., PMID:32822029

Blocking histone methyltransferase SETDB1 inhibits tumorigenesis and enhances cetuximab sensitivity in colorectal cancer., PMID:32473242

Application of dual reading domains as novel reagents in chromatin biology reveals a new H3K9me3 and H3K36me2/3 bivalent chromatin state., PMID:28946896

Subsets of Visceral Adipose Tissue Nuclei with Distinct Levels of 5-Hydroxymethylcytosine., PMID:27171244

Analysis of the subcellular localization of the human histone methyltransferase SETDB1., PMID:26296461

The histone methyltransferase ESET is required for the survival of spermatogonial stem/progenitor cells in mice., PMID:24763053

Roles of histone H3K9 methyltransferases during Drosophila spermatogenesis., PMID:22476432

Characterization of HIV Tat modifications using novel methyl-lysine-specific antibodies., PMID:20615470

SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins., PMID:11959841

Datasheet

Document Download

Anti-SETDB1 Antibody (R3T51).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

Contact Information

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For research use only. Not for human or drug use.

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Anti-SETDB1 Antibody (R3T51) [RHG99501]
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