Catalog No.
RHG90203
Species reactivity
Human, Mouse, Rat, Monkey
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
CAP4, MCH5, FADD-homologous ICE/ced-3-like protease, FLICE, Apoptotic cysteine protease, MORT1-associated ced-3 homolog, MACH, FADD-like ICE, ICE-like apoptotic protease 5, CASP8, CASP-8, Caspase-8, Apoptotic protease Mch-5
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q14790
Applications
ELISA, FCM, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3T33
IL-33 facilitates endoplasmic reticulum stress and pyroptosis in LPS-stimulated ARDS model in vitro., PMID:40118005
CASP8 intronic expansion identified by poly-glycine-arginine pathology increases Alzheimer's disease risk., PMID:39937857
The Clinical and Molecular Response of Pyoderma Gangrenosum to IL-23 Blockade: Result from a Proof-of-Concept Open-Label Clinical Trial., PMID:39547392
Evaluation of inflammatory biomarkers and their association with anti-SARS-CoV-2 antibody titers in healthcare workers vaccinated with BNT162B2., PMID:39247198
Formononetin inhibits IgE by huPlasma/PBMCs and mast cells/basophil activation via JAK/STAT/PI3-Akt pathways., PMID:39221239
Spatial characterization of interface dermatitis in cutaneous lupus reveals novel chemokine ligand-receptor pairs that drive disease., PMID:38260617
Wilms' tumor 1 (WT1) antigen is overexpressed in Kaposi Sarcoma and is regulated by KSHV vFLIP., PMID:38190392
Inflammatory related plasma proteins involved in acute preschool wheeze., PMID:38006384
Paraneoplastic or not? Sirtuin 2 in anti-N-methyl-d-aspartate receptor encephalitis., PMID:37483157
Identification of pre-infection markers and differential plasma protein expression following SARS-CoV-2 infection in people living with HIV., PMID:36966617
Caspase-8 activation in neutrophils facilitates autoimmune kidney vasculitis through regulating CD4+ effector memory T cells., PMID:36505410
cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis., PMID:36414711
Artificial Intelligence Predicted Overall Survival and Classified Mature B-Cell Neoplasms Based on Immuno-Oncology and Immune Checkpoint Panels., PMID:36358737
Single cell analysis of PANoptosome cell death complexes through an expansion microscopy method., PMID:36169732
Immune responses to Vibrio vulnificus formalin-killed vaccine and ghost vaccine in Scophthalmus maximus., PMID:35771999
Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage., PMID:35077396
Generation of human long-lived plasma cells by developmentally regulated epigenetic imprinting., PMID:34952892
Artificial Neural Networks Predicted the Overall Survival and Molecular Subtypes of Diffuse Large B-Cell Lymphoma Using a Pancancer Immune-Oncology Panel., PMID:34945004
Kaempferol sensitizes tumor necrosis factor-related apoptosis-inducing ligand-resistance chronic myelogenous leukemia cells to apoptosis., PMID:34820749
LOX-1 Regulates Neutrophil Apoptosis and Fungal Load in A. Fumigatus Keratitis., PMID:34264144
Next Generation Sequencing for Detecting Somatic FAS Mutations in Patients With Autoimmune Lymphoproliferative Syndrome., PMID:33995372
Casp8 acts through A20 to inhibit PD-L1 expression: The mechanism and its implication in immunotherapy., PMID:33934451
Anti-cancer effect of combined action of anti-MUC1 and rosmarinic acid in AGS gastric cancer cells., PMID:33930385
Death agonist antibody against TRAILR2/DR5/TNFRSF10B enhances birinapant anti-tumor activity in HPV-positive head and neck squamous cell carcinomas., PMID:33737574
Effects of Different Chromium Compounds on Hematology and Inflammatory Cytokines in Rats Fed High-Fat Diet., PMID:33717096
Endothelial cells response to neutrophil-derived extracellular vesicles miRNAs in anti-PR3 positive vasculitis., PMID:33527387
Identification of novel autoantibodies based on the protein chip encoded by cancer-driving genes in detection of esophageal squamous cell carcinoma., PMID:33457096
Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19., PMID:33239683
TNF Signaling Dictates Myeloid and Non-Myeloid Cell Crosstalk to Execute MCMV-Induced Extrinsic Apoptosis., PMID:33126536
DR5-targeted, chemotherapeutic drug-loaded nanoparticles induce apoptosis and tumor regression in pancreatic cancer in vivo models., PMID:32504778
Identification of Reference Genes in Chicken Intraepithelial Lymphocyte Natural Killer Cells Infected with Very-virulent Infectious Bursal Disease Virus., PMID:32444639
Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis., PMID:32428502
Downregulation of c‑FLIP and upregulation of DR‑5 by cantharidin sensitizes TRAIL‑mediated apoptosis in prostate cancer cells via autophagy flux., PMID:32319535
Occurrence of Retinal Ganglion Cell Loss via Autophagy and Apoptotic Pathways in an Autoimmune Glaucoma Model., PMID:31935132
Programmed delivery of cyclopeptide RA-V and antisense oligonucleotides for combination therapy on hypoxic tumors and for therapeutic self-monitoring., PMID:31687671
PI3K/AKT inhibitors aggravate death receptor-mediated hepatocyte apoptosis and liver injury., PMID:31445927
ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells., PMID:31443721
Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV- and HPV+ Head and Neck Cancers to TNFα, TRAIL, and Radiation Therapy., PMID:31266830
Atg14 protects the intestinal epithelium from TNF-triggered villus atrophy., PMID:30894050
Hepatitis B Virus Surface Antigen Enhances the Sensitivity of Hepatocytes to Fas-Mediated Apoptosis via Suppression of AKT Phosphorylation., PMID:30171166
TLR4-MyD88 pathway promotes the imbalanced activation of NLRP3/NLRP6 via caspase-8 stimulation after alkali burn injury., PMID:30008389
OTULIN limits cell death and inflammation by deubiquitinating LUBAC., PMID:29950720
Cadmium-induced apoptosis in neuronal cells is mediated by Fas/FasL-mediated mitochondrial apoptotic signaling pathway., PMID:29891925
Blockade of TNF receptor superfamily 1 (TNFR1)-dependent and TNFR1-independent cell death is crucial for normal epidermal differentiation., PMID:29596938
Magnetic nanoparticle-mediated gene therapy to induce Fas apoptosis pathway in breast cancer., PMID:29593359
Inorganic arsenic causes apoptosis cell death and immunotoxicity on European sea bass (Dicentrarchus labrax)., PMID:29571380
Treatment of Donor Rat Hearts Prior to Transplantation with FLIP (FADD-Like Interleukin Beta-Converting Enzyme (FLICE)-Like Inhibitory Protein) in Cardioplegic Solution Decreased Apoptosis at Thirty Minutes Post-transplantation and Decreased Total Tyrosine Phosphorylation Levels., PMID:29483486
TNF-α increases Staphylococcus aureus-induced death of human alveolar epithelial cell line A549 associated with RIP3-mediated necroptosis., PMID:29330116
Proteomic Profiling for Cardiovascular Biomarker Discovery in Orthostatic Hypotension., PMID:29295851
Ginkgetin inhibits proliferation of human leukemia cells via the TNF-α signaling pathway., PMID:28902633
For research use only. Not for human or drug use.
