Catalog No.
RHG55101
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400
Target
GRB2-associated binder 1, Growth factor receptor bound protein 2-associated protein 1, GAB1, GRB2-associated-binding protein 1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q13480
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3S55
Molecular classification of medulloblastoma using immunohistochemistry: A single centre study., PMID:40056547
[Mechanism of Paeoniae Radix Rubra and Aconiti Lateralis Radix Praeparata herbal pair in promoting hepatocellular regeneration in chronic acute liver failure based on HGF/PI3K/Akt signaling axis]., PMID:39307751
Dynamic altruistic cooperation within breast tumors., PMID:38093346
A novel bivalent anti-c-MET/PD-1 bispecific antibody exhibits potent cytotoxicity against c-MET/PD-L1-positive colorectal cancer., PMID:37646958
Immunohistochemical Surrogates for Molecular Stratification in Medulloblastoma., PMID:37471625
Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL., PMID:37169950
Clinicomorphological and molecular analysis of medulloblastoma and association with survival: A single tertiary care center experience., PMID:38384024
Anti-c-MET Fab-Grb2-Gab1 Fusion Protein-Mediated Interference of c-MET Signaling Pathway Induces Methuosis in Tumor Cells., PMID:36233320
Subcellular Dynamic Immunopatterning of Cytosolic Protein Complexes on Microstructured Polymer Substrates., PMID:34652152
Medulloblastoma: clinicopathological parameters, risk stratification, and survival analysis of immunohistochemically validated molecular subgroups., PMID:33555447
Diagnostic Accuracy of a Reduced Immunohistochemical Panel in Medulloblastoma Molecular Subtyping, Correlated to DNA-methylation Analysis., PMID:33323893
Mechanisms of miR‑128‑3p in inhibiting osteoblast differentiation from bone marrow‑derived mesenchymal stromal cells., PMID:33174052
Systems analysis of protein signatures predicting cetuximab responses in KRAS, NRAS, BRAF and PIK3CA wild-type patient-derived xenograft models of metastatic colorectal cancer., PMID:32700762
Medulloblastoma, WNT-activated/SHH-activated: clinical impact of molecular analysis and histogenetic evaluation., PMID:29582169
Large-Scale Phosphoproteomics Reveals Shp-2 Phosphatase-Dependent Regulators of Pdgf Receptor Signaling., PMID:29514104
Medulloblastoma with myogenic and/or melanotic differentiation does not align immunohistochemically with the genetically defined molecular subgroups., PMID:29412177
Characterization of In Vivo Resistance to Osimertinib and JNJ-61186372, an EGFR/Met Bispecific Antibody, Reveals Unique and Consensus Mechanisms of Resistance., PMID:28830985
Measurement of Epidermal Growth Factor Receptor-Derived Signals Within Plasma Membrane Clathrin Structures., PMID:28791645
Soft tissue angiofibroma: Clinicopathologic, immunohistochemical and molecular analysis of 14 cases., PMID:28639284
Uniformity under in vitro conditions: Changes in the phenotype of cancer cell lines derived from different medulloblastoma subgroups., PMID:28231263
Molecular Characterization of Striated Muscle-Specific Gab1 Isoform as a Critical Signal Transducer for Neuregulin-1/ErbB Signaling in Cardiomyocytes., PMID:27861634
Targeted nanoconjugate co-delivering siRNA and tyrosine kinase inhibitor to KRAS mutant NSCLC dissociates GAB1-SHP2 post oncogene knockdown., PMID:27530552
MicroRNAs in B-cell lymphomas: how a complex biology gets more complex., PMID:25541152
Microenvironment-derived HGF overcomes genetically determined sensitivity to anti-MET drugs., PMID:25217525
B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells., PMID:25080849
miR in CLL: more than mere markers of prognosis?, PMID:24993874
miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1., PMID:24787006
Tyrosine phosphorylation of the orphan receptor ESDN/DCBLD2 serves as a scaffold for the signaling adaptor CrkL., PMID:23770091
Acquired substrate preference for GAB1 protein bestows transforming activity to ERBB2 kinase lung cancer mutants., PMID:23612964
KRC-327, a selective novel inhibitor of c-Met receptor tyrosine kinase with anticancer activity., PMID:23340177
Macroporous hydrogel micropillars for quantifying Met kinase activity in cancer cell lysates., PMID:22814332
Dual inhibition of Met kinase and angiogenesis to overcome HGF-induced EGFR-TKI resistance in EGFR mutant lung cancer., PMID:22789825
Hepatocyte growth factor induces resistance to anti-epidermal growth factor receptor antibody in lung cancer., PMID:22089117
Osteoblastic molecular scaffold Gab1 is required for maintaining bone homeostasis., PMID:20124419
Immunomodulation of human B cells following treatment with intravenous immunoglobulins involves increased phosphorylation of extracellular signal-regulated kinases 1 and 2., PMID:18689724
c-Met must translocate to the nucleus to initiate calcium signals., PMID:18073207
Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades., PMID:16940750
Role of Per1-interacting protein of the suprachiasmatic nucleus in NGF mediated neuronal survival., PMID:16298334
The BCR signalosome: where cell fate is decided., PMID:16178270
Agonist Met antibodies define the signalling threshold required for a full mitogenic and invasive program of Kaposi's Sarcoma cells., PMID:16039997
Six post-implantation lethal knockouts of genes for lipophilic MAPK pathway proteins are expressed in preimplantation mouse embryos and trophoblast stem cells., PMID:15736129
Entire mitogen activated protein kinase (MAPK) pathway is present in preimplantation mouse embryos., PMID:15305288
The absence of Grb2-associated binder 2 (Gab2) does not disrupt NK cell development and functions., PMID:15240750
Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects., PMID:15059917
Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation., PMID:14974085
GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2., PMID:12819203
Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent., PMID:12640125
Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling., PMID:12486104
Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction: is it a mechanoresponsive molecule?, PMID:12177047
Crk synergizes with epidermal growth factor for epithelial invasion and morphogenesis and is required for the met morphogenic program., PMID:12138161
For research use only. Not for human or drug use.
