Catalog No.
RHG53903
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
IHC: 1:100-1:200
Target
AIG6, 51 kDa FKBP, FKBP51, FKBP54, Rotamase, Peptidyl-prolyl cis-trans isomerase FKBP5, FF1 antigen, 51 kDa FK506-binding protein, FKBP-51, Androgen-regulated protein 6, p54, PPIase FKBP5, 54 kDa progesterone receptor-associated immunophilin, HSP90-binding immunophilin, FKBP-5, FK506-binding protein 5, FKBP5
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q13451
Applications
IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3S48
Exploration of the Shared Gene Signatures and Molecular Mechanisms between Chronic Bronchitis and Antineutrophil Cytoplasmic Antibody-associated Glomerulonephritis: Evidence from Transcriptome Data., PMID:38847168
High dose androgen suppresses natural killer cytotoxicity of castration-resistant prostate cancer cells via altering AR/circFKBP5/miRNA-513a-5p/PD-L1 signals., PMID:36038573
Single-cell RNA Sequencing Analysis Reveals New Immune Disorder Complexities in Hypersplenism., PMID:35865544
Adsorptive Microtiter Plates As Solid Supports in Affinity Purification Workflows., PMID:34669399
The Gut Microbiota Affects Corticosterone Production in the Murine Small Intestine., PMID:33921780
Combining Magnetic Resonance Imaging with Systemic Monocyte Evaluation for the Implementation of GBM Management., PMID:33917598
Myelination defects in the medial prefrontal cortex of Fkbp5 knockout mice., PMID:33410216
Downregulation of PD-L1 via FKBP5 by celecoxib augments antitumor effects of PD-1 blockade in a malignant glioma model., PMID:32642723
Alternative macrophage polarisation associated with resistance to anti-PD1 blockade is possibly supported by the splicing of FKBP51 immunophilin in melanoma patients., PMID:32317723
An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes., PMID:31467037
Bioinformatics Analyses Determined the Distinct CNS and Peripheral Surrogate Biomarker Candidates Between Two Mouse Models for Progressive Multiple Sclerosis., PMID:30941144
Glucocorticoid insensitivity by staphylococcal enterotoxin B in keratinocytes of allergic dermatitis is associated with impaired nuclear translocation of the Glucocorticoid Receptor α., PMID:30522881
Association of an IRF3 putative functional uORF variant with resistance to Brucella infection: A candidate gene based analysis of InDel polymorphisms in goats., PMID:30477986
FKBP51 modulates steroid sensitivity and NFκB signalling: A novel anti-inflammatory drug target., PMID:30169894
Successful treatment of FKBP51-expressed multicentric reticulohistiocytosis using combination therapy with low-dose denosumab and tacrolimus., PMID:26652057
Polymorphism in COMT is associated with IgG3 subclass level and susceptibility to infection in patients with chronic fatigue syndrome., PMID:26272340
Sustained interleukin-1β exposure modulates multiple steps in glucocorticoid receptor signaling, promoting split-resistance to the transactivation of prominent anti-inflammatory genes by glucocorticoids., PMID:25977599
Interleukin-8 is a key mediator of FKBP51-induced melanoma growth, angiogenesis and metastasis., PMID:25942396
Anti-inflammatory mechanisms of bioactive milk proteins in the intestine of newborns., PMID:23660296
The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress., PMID:21730050
Neuropsin cleaves EphB2 in the amygdala to control anxiety., PMID:21508957
Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: implications for major depressive disorder., PMID:19545546
FK506-binding protein 51 regulates nuclear transport of the glucocorticoid receptor beta and glucocorticoid responsiveness., PMID:18326728
Progesterone receptor deficient in chromatin binding has an altered cellular state., PMID:14744870
For research use only. Not for human or drug use.
