Catalog No.
RHG44804
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:100-1:500
Target
GluN2B, Glutamate receptor ionotropic, NMDA 2B, GRIN2B, NMDAR2B, NR2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl-D-aspartate receptor subunit 3, N-methyl D-aspartate receptor subtype 2B, hNR3, NR3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q13224
Applications
ELISA, FCM, IF
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3S24
IgG-NR2B-A Potentially Valuable Biomarker in the Management of Refractory Anti-NMDAR Encephalitis., PMID:39859226
Assembly and architecture of endogenous NMDA receptors in adult cerebral cortex and hippocampus., PMID:39855198
Novel mechanisms of Anshen Dingzhi prescription against PTSD: Inhibiting DCC to modulate synaptic function and inflammatory responses., PMID:38848974
Alleviation of migraine related pain and anxiety by inhibiting calcium-stimulating AC1-dependent CGRP in the insula of adult rats., PMID:38760739
A gene expression signature in HER2+ breast cancer patients related to neoadjuvant chemotherapy resistance, overall survival, and disease-free survival., PMID:36338974
Neuroprotective effects of ergosterol against TNF-α-induced HT-22 hippocampal cell injury., PMID:36030584
Prediction of the cognitive impairment development in patients with autoimmune thyroiditis and hypothyroidism., PMID:35843716
Development and characterization of functional antibodies targeting NMDA receptors., PMID:35177668
NMDA receptors control development of somatosensory callosal axonal projections., PMID:33661095
Characteristics of internalization of NMDA-type GluRs with antibodies to GluN1 and GluN2B., PMID:33091764
Co-expression of NMDA-receptor subunits NR1, NR2A, and NR2B in dysplastic neurons of teratomas in patients with paraneoplastic NMDA-receptor-encephalitis: a retrospective clinico-pathology study of 159 patients., PMID:32771066
Endomorphin analog exhibited superiority in alleviating neuropathic hyperalgesia via weak activation of NMDA receptors., PMID:32666510
Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory., PMID:32179753
Ketamine reduces remifentanil-induced postoperative hyperalgesia mediated by CaMKII-NMDAR in the primary somatosensory cerebral cortex region in mice., PMID:31541650
Downregulation of hippocampal NR2A/2B subunits related to cognitive impairment in a pristane-induced lupus BALB/c mice., PMID:31498792
ROR2 modulates neuropathic pain via phosphorylation of NMDA receptor subunit GluN2B in rats., PMID:30916039
Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice., PMID:30572184
Clinical significance of anti-DNA/N-methyl-D-aspartate receptor 2 antibodies in de novo and post-steroid cases with neuropsychiatric systemic lupus erythematosus., PMID:30358102
NMDA Receptor Autoantibodies in Autoimmune Encephalitis Cause a Subunit-Specific Nanoscale Redistribution of NMDA Receptors., PMID:29949761
Efficacy and mechanism of action of etanercept in bone cancer pain., PMID:29441991
A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate (NMDA) Receptor in Blood., PMID:29364283
Epileptic spasms secondary to acute cerebral and cerebellar encephalitis., PMID:29198411
Understanding the Antibody Repertoire in Neuropsychiatric Systemic Lupus Erythematosus and Neuromyelitis Optica Spectrum Disorder: Do They Share Common Targets?, PMID:29073350
Hypoxia-ischemia modifies postsynaptic GluN2B-containing NMDA receptor complexes in the neonatal mouse brain., PMID:28993251
A systems medicine approach for finding target proteins affecting treatment outcomes in patients with non-Hodgkin lymphoma., PMID:28892521
Hyaluronic acid based extracellular matrix regulates surface expression of GluN2B containing NMDA receptors., PMID:28887453
Effects of Tumor Necrosis Factor Blocker on Salicylate-Induced Tinnitus in Mice., PMID:28723598
The fine tuning of retinocollicular topography depends on reelin signaling during early postnatal development of the rat visual system., PMID:28602919
CXCL13 regulates the trafficking of GluN2B-containing NMDA receptor via IL-17 in the development of remifentanil-induced hyperalgesia in rats., PMID:28359934
Anti-N-methyl-D-aspartate receptor antibodies are associated with fibromyalgia in patients with systemic lupus erythematosus: a case-control study., PMID:28339361
Epilepsy with myoclonic atonic seizures and chronic cerebellar symptoms associated with antibodies against glutamate receptors N2B and D2 in serum and cerebrospinal fluid., PMID:28246062
Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation., PMID:28232581
[A case of neurosyphilis presenting with limbic encephalitis]., PMID:27980287
Involvement of Brain-Enriched Guanylate Kinase-Associated Protein (BEGAIN) in Chronic Pain after Peripheral Nerve Injury., PMID:27785460
Immunological studies of cerebrospinal fluid from patients with CNS symptoms after human papillomavirus vaccination., PMID:27609278
Antibodies against peptides of NMDA-type GluR in cerebrospinal fluid of patients with epileptic spasms., PMID:27515477
Encephalitis With Antibodies to GluN2B During Administration of Clozapine., PMID:27482955
Evaluation of titers of antibodies against peptides of subunits NR1 and NR2B of glutamate receptor by enzyme-linked immunosorbent assay in psychiatric patients with anti-thyroid antibodies., PMID:27317996
Absence of NMDA receptor antibodies in the rare association between Type 1 Narcolepsy and Psychosis., PMID:27143278
IGF-1-Involved Negative Feedback of NR2B NMDA Subunits Protects Cultured Hippocampal Neurons Against NMDA-Induced Excitotoxicity., PMID:26758454
SIRPα1-SHP2 Interaction Regulates Complete Freund Adjuvant-Induced Inflammatory Pain via Src-Dependent GluN2B Phosphorylation in Rats., PMID:26720617
Integrative neuroscience approach to neuropsychiatric lupus., PMID:26467973
Wnt/Ryk signaling contributes to neuropathic pain by regulating sensory neuron excitability and spinal synaptic plasticity in rats., PMID:26407042
Ethanol upregulates NMDA receptor subunit gene expression in human embryonic stem cell-derived cortical neurons., PMID:26266540
Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology., PMID:26252487
A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling., PMID:26027736
Semi-quantitative analyses of antibodies to N-methyl-d-aspartate type glutamate receptor subunits (GluN2B & GluN1) in the clinical course of Rasmussen syndrome., PMID:25986190
Immediate suppression of seizure clusters by corticosteroids in PCDH19 female epilepsy., PMID:25891919
Expression of N-methyl-D-aspartate receptor subunits in the bovine ovum: ova as a potential source of autoantigens causing anti-NMDAR encephalitis., PMID:25786541
[Identification of NMDA receptor in normal bovine ovary and ovum]., PMID:25672700
For research use only. Not for human or drug use.
