Catalog No.
RHG43202
Species reactivity
Human, Monkey
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
IF: 1:200-1:1000, IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
S6/H4 kinase, p21-activated kinase 2, p58, PAK-2, PAK2, C-t-PAK2, PAK65, p34, Gamma-PAK, Serine/threonine-protein kinase PAK 2, p27
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q13177
Applications
IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3S18
4D label-free quantitative proteomic and phosphoproteomic profiling of the kidney in rat models of antimyeloperoxidase-associated vasculitis., PMID:40201969
PAK1 overexpression promotes myxofibrosarcoma angiogenesis through STAT5B-mediated CSF2 transactivation: clinical and therapeutic relevance of amplification and nuclear entry., PMID:37564209
A study of the mechanisms responsible for the action of new immunosuppressants and their effects on rat small intestinal transplantation., PMID:34785307
Cdk1 phosphorylation negatively regulates the activity of Net1 towards RhoA during mitosis., PMID:33465404
Proinflammatory Mediators, IL (Interleukin)-1β, TNF (Tumor Necrosis Factor) α, and Thrombin Directly Induce Capillary Tube Regression., PMID:31852224
Pak2 is essential for the function of Foxp3+ regulatory T cells through maintaining a suppressive Treg phenotype., PMID:29213081
Low level Hg2+ exposure modulates the B-cell cytoskeletal phosphoproteome., PMID:29199152
Transcriptome Analysis of Peripheral Blood in Chronic Inflammatory Demyelinating Polyradiculoneuropathy Patients Identifies TNFR1 and TLR Pathways in the IVIg Response., PMID:27175635
Effect of omega-3 polyunsaturated fatty acids on the cytoskeleton: an open-label intervention study., PMID:25971815
A multiparametric serum marker panel as a complementary test to mammography for the diagnosis of node-negative early-stage breast cancer and DCIS in young women., PMID:24957886
Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody., PMID:24620746
Identification and validation of new autoantibodies for the diagnosis of DCIS and node negative early-stage breast cancers., PMID:22886747
Nef surfaces: where to interfere with function., PMID:22103838
p21-activated kinases regulate actin remodeling in glomerular podocytes., PMID:20071462
The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties., PMID:18507705
Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF., PMID:16966330
Identification and characterization of HLA-class-I-restricted T-cell epitopes in the putative tumor-associated antigens P21-activated serin kinase 2 (PAK2) and cyclin-dependent kinase inhibitor 1A (CDKN1A)., PMID:16718496
Light-Induced photoreceptor degeneration in the mouse involves activation of the small GTPase Rac1., PMID:16505058
Production and use of a cell permeable inhibitor of group A Paks (TAT-PID) to analyze signal transduction., PMID:16288885
Sertoli-germ cell anchoring junction dynamics in the testis are regulated by an interplay of lipid and protein kinases., PMID:15870075
Anti-phosphopeptide antibody, P-STM as a novel tool for detecting mitotic phosphoproteins: identification of lamins A and C as two major targets., PMID:15597429
Signaling but not trafficking function of HIV-1 protein Nef is essential for Nef-induced defects in human intrathymic T-cell development., PMID:12855553
Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin., PMID:12453877
Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin., PMID:12237306
Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization., PMID:11782491
Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK., PMID:11121037
Inhibition of CD95/Fas-induced DNA degradation by osmotic cell shrinkage., PMID:11093032
Identification of the Nef-associated kinase as p21-activated kinase 2., PMID:10607567
PAK2 is cleaved and activated during hyperosmotic shock-induced apoptosis via a caspase-dependent mechanism: evidence for the involvement of oxidative stress., PMID:9989786
Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart., PMID:9779826
Heat shock stress induces cleavage and activation of PAK2 in apoptotic cells., PMID:9717744
Proteolytic cleavage and activation of PAK2 during UV irradiation-induced apoptosis in A431 cells., PMID:9712143
Identification of the regulatory autophosphorylation site of autophosphorylation-dependent protein kinase (auto-kinase). Evidence that auto-kinase belongs to a member of the p21-activated kinase family., PMID:9693111
The renaturable 69- and 63-kDa protein kinases that undergo rapid activation in chemoattractant-stimulated guinea pig neutrophils are p21-activated kinases., PMID:8798763
Human pancreatic adenocarcinoma-associated antigens defined by novel murine monoclonal antibodies Pak-1 and Pak-2., PMID:2161375
For research use only. Not for human or drug use.
