Anti-TRAF2 Antibody (R3R98)

Catalog No.

RHG34301

Species reactivity

Human

Host species

Mouse

Isotype

IgG2b

Clonality

Monoclonal

Tested applications

ELISA: 1:10000, FCM: 1:200-1:400, WB: 1:500-1:2000

Target

TRAP3, RING-type E3 ubiquitin transferase TRAF2, E3 ubiquitin-protein ligase TRAF2, Tumor necrosis factor type 2 receptor-associated protein 3, TRAF2, TNF receptor-associated factor 2

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q12933

Applications

ELISA, FCM, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3R98

KIF26B promotes bladder cancer progression via activating Wnt/β-catenin signaling in a TRAF2-dependent pathway., PMID:40253697

PeiTuQingXin formula alleviated atopic dermatitis symptoms via inhibiting TRADD/TRAF2/RIP1 complex mediated NF-κB signaling pathway activation., PMID:40056166

Potential role of TRAF2 in pulmonary hypertension in broiler chickens and preparation and specificity analysis of its polyclonal antibody., PMID:39798767

Evaluation of an F Protein-Based Recombinant Protein for Immunization Against Respiratory Syncytial Virus., PMID:39791530

Ubiquitination of CD47 Regulates Innate Anti-Tumor Immune Response., PMID:39665172

USP24 promotes hepatocellular carcinoma tumorigenesis through deubiquitinating and stabilizing TRAF2., PMID:39127151

Associations of TRAF2 (rs867186), TAB2 (rs237025), IKBKB (rs13278372) Polymorphisms and TRAF2, TAB2, IKBKB Protein Levels with Clinical and Morphological Features of Pituitary Adenomas., PMID:39061149

Molecular signatures in prion disease: altered death receptor pathways in a mouse model., PMID:38802941

TRAF6 and TRAF2/3 Binding Motifs in CD40 Differentially Regulate B Cell Function in T-Dependent Antibody Responses and Dendritic Cell Function in Experimental Autoimmune Encephalomyelitis., PMID:37921511

The CD40 agonist HERA-CD40L results in enhanced activation of antigen presenting cells, promoting an anti-tumor effect alone and in combination with radiotherapy., PMID:37304285

CD40 Upregulation in the Retina of Patients With Diabetic Retinopathy: Association With TRAF2/TRAF6 Upregulation and Inflammatory Molecule Expression., PMID:37294707

Deficiency of germinal center kinase TRAF2 and NCK-interacting kinase (TNIK) in B cells does not affect atherosclerosis., PMID:37215541

Unique immune and inflammatory cytokine profiles may define long COVID syndrome., PMID:37061998

Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy., PMID:36334887

Genome-Wide Super-Enhancer-Based Analysis: Identification of Prognostic Genes in Oral Squamous Cell Carcinoma., PMID:36012427

Dietary aflatoxin B1 caused the growth inhibition, and activated oxidative stress and endoplasmic reticulum stress pathway, inducing apoptosis and inflammation in the liver of northern snakehead (Channa argus)., PMID:35964742

OX40 Expression in Eosinophils Aggravates OVA-Induced Eosinophilic Gastroenteritis., PMID:35720294

TRAF3 plays a role in lupus nephritis by regulating Th17 cell and Treg cell balance as well as NF-κB signaling pathway in mice., PMID:35416178

LILRB3 supports acute myeloid leukemia development and regulates T-cell antitumor immune responses through the TRAF2-cFLIP-NF-κB signaling axis., PMID:35122056

Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer., PMID:34898004

A QP509L/QP383R-Deleted African Swine Fever Virus Is Highly Attenuated in Swine but Does Not Confer Protection against Parental Virus Challenge., PMID:34613824

QNZ alleviated hepatocellular carcinoma by targeting inflammatory pathways in a rat model., PMID:34564023

Identification of covalent modifications regulating immune signaling complex composition and phenotype., PMID:34318608

The Traf2DNxBCL2-tg Mouse Model of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Recapitulates the Biased IGHV Gene Usage, Stereotypy, and Antigen-Specific HCDR3 Selection of Its Human Counterpart., PMID:33912159

TNF receptor-associated factor 3 restrains B-cell receptor signaling in normal and malignant B cells., PMID:33639170

BAFF, involved in B cell activation through the NF-κB pathway, is related to disease activity and bone destruction in rheumatoid arthritis., PMID:33483588

Etanercept as a TNF-alpha inhibitor depresses experimental retinal neovascularization., PMID:33043386

Variation in genes implicated in B-cell development and antibody production affects susceptibility to pemphigus., PMID:32926429

Identification of MALT1 feedback mechanisms enables rational design of potent antilymphoma regimens for ABC-DLBCL., PMID:32785655

TRAF3 Acts as a Checkpoint of B Cell Receptor Signaling to Control Antibody Class Switch Recombination and Anergy., PMID:32591397

Tumor Necrosis Factor (TNF) Receptor Expression Determines Keratinocyte Fate upon Stimulation with TNF-Like Weak Inducer of Apoptosis., PMID:31885495

Downregulation of TNF-α/TNF-R1 Signals by AT-Lipoxin A4 May Be a Significant Mechanism of Attenuation in SAP-Associated Lung Injury., PMID:31097921

CD137 (4-1BB) Signalosome: Complexity Is a Matter of TRAFs., PMID:30524423

Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis., PMID:30471110

Paeoniflorin-6'-O-benzene sulfonate alleviates collagen-induced arthritis in mice by downregulating BAFF-TRAF2-NF-κB signaling: comparison with biological agents., PMID:30446734

[Effect of human monocytes on coal tar pitch extract-induced TRAF2 mRNA expression in human bronchial epithelial cells]., PMID:29903256

Primary and Metastatic Melanoma With NTRK Fusions., PMID:29683819

Factor VIIa induces anti-inflammatory signaling via EPCR and PAR1., PMID:29669778

Deubiquitinases A20 and CYLD modulate costimulatory signaling via CD137 (4-1BB)., PMID:29296520

SYK inhibition thwarts the BAFF - B-cell receptor crosstalk and thereby antagonizes Mcl-1 in chronic lymphocytic leukemia., PMID:28838991

A novel synthetic analogue of ω-3 17,18-epoxyeicosatetraenoic acid activates TNF receptor-1/ASK1/JNK signaling to promote apoptosis in human breast cancer cells., PMID:28798154

Impaired TNF/TNFR2 signaling enhances Th2 and Th17 polarization and aggravates allergic airway inflammation., PMID:28619762

B-cell Function Gene Mutations in Diffuse Large B-cell Lymphoma: A Retrospective Cohort Study., PMID:28153771

Targeted deletion of Traf2 allows immunosuppression-free islet allograft survival in mice., PMID:28062921

CD70/CD27 signaling promotes blast stemness and is a viable therapeutic target in acute myeloid leukemia., PMID:28031480

TNF-α-Induced cPLA2 Expression via NADPH Oxidase/Reactive Oxygen Species-Dependent NF-κB Cascade on Human Pulmonary Alveolar Epithelial Cells., PMID:27932980

Forsythoside A Inhibits BVDV Replication via TRAF2-Dependent CD28-4-1BB Signaling in Bovine PBMCs., PMID:27617959

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease., PMID:27503909

A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1., PMID:27135603

MAP4K Family Kinases in Immunity and Inflammation., PMID:26791862

Document Download

Anti-TRAF2 Antibody (R3R98).pdf