Catalog No.
RHG18203
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400
Target
Retinoblastoma-like protein 2, RBL2, RB2, Retinoblastoma-related protein 2, p130, RBR-2, 130 kDa retinoblastoma-associated protein, pRb2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q08999
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3R75
[The cell cycle regulator p130 and beta-catenin form a complex in mesenchymal stem cells]., PMID:21516817
Effects of the combined blockade of EGFR and ErbB-2 on signal transduction and regulation of cell cycle regulatory proteins in breast cancer cells., PMID:19946741
A small molecule based on the pRb2/p130 spacer domain leads to inhibition of cdk2 activity, cell cycle arrest and tumor growth reduction in vivo., PMID:17043661
In vivo inactivation of pRb, p107 and p130 in murine neuroprogenitor cells leads to major CNS developmental defects and high seizure rates., PMID:16979903
Glycogen synthase kinase 3 phosphorylates RBL2/p130 during quiescence., PMID:15456871
Expression of the retinoblastoma family of tumor suppressors during murine embryonic orofacial development., PMID:12627794
BCR signals target p27(Kip1) and cyclin D2 via the PI3-K signalling pathway to mediate cell cycle arrest and apoptosis of WEHI 231 B cells., PMID:11704865
Cyr61, a member of CCN family, is a tumor suppressor in non-small cell lung cancer., PMID:11598125
pRb2/p130 protein expression is correlated with clinicopathologic findings in patients with oral squamous cell carcinoma., PMID:11596028
Expression of a human polyomavirus oncoprotein and tumour suppressor proteins in medulloblastomas., PMID:11577176
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer., PMID:11030152
Purified JC virus T and T' proteins differentially interact with the retinoblastoma family of tumor suppressor proteins., PMID:10936097
Interaction between the pRb2/p130 C-terminal domain and the N-terminal portion of cyclin D3., PMID:10572252
The RB-related gene Rb2/p130 in neuroblastoma differentiation and in B-myb promoter down-regulation., PMID:10200489
The role of pRb2/p130 protein in diagnosing lung carcinoma on fine needle aspiration biopsies., PMID:10093823
Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation., PMID:9819434
Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene., PMID:9806916
pRb and p107 regulate E2F activity during lens fiber cell differentiation., PMID:9467965
E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry., PMID:8657117
The RB2/p130 gene product is a nuclear protein whose phosphorylation is cell cycle regulated., PMID:8567757
Cell cycle-specific association of E2F with the p130 E1A-binding protein., PMID:8253385
The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E., PMID:8253383
For research use only. Not for human or drug use.
