Catalog No.
RHG18001
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000, WB: 1:500-1:2000
Target
IL-2-inducible T-cell kinase, Kinase EMT, LYK, ITK, EMT, Tyrosine-protein kinase Lyk, Tyrosine-protein kinase ITK/TSK, T-cell-specific kinase, Interleukin-2-inducible T-cell kinase
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q08881
Applications
ELISA, FCM, IF, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3R74
Phase I study of pembrolizumab in combination with ibrutinib for the treatment of unresectable or metastatic melanoma., PMID:39967670
Impact of ibrutinib on inflammation in a mouse model of Graves' orbitopathy., PMID:39280007
Dihydroartemisinin inhibits follicular helper T and B cells: implications for systemic lupus erythematosus treatment., PMID:38977652
Brentuximab Vedotin Plus Ibrutinib in Relapsed and Refractory Hodgkin Lymphoma., PMID:38693037
Differentially Expressed Genes Involved in Primary Resistance to Immunotherapy in Patients with Advanced-Stage Pulmonary Cancer., PMID:38396726
Targeting kinase ITK treats autoimmune arthritis via orchestrating T cell differentiation and function., PMID:37992572
Regulation of Cx43 Gap Junction Intercellular Communication by Bruton's Tyrosine Kinase and Interleukin-2-Inducible T-Cell Kinase., PMID:37189407
Investigating combination benefit of PD1 and LAG3 co-blockade using an engineered cellular bioassay., PMID:37044037
Discovery of Potent and Highly Selective Interleukin-2-Inducible T-Cell Kinase Degraders with In Vivo Activity., PMID:36959108
Novel Molecular Therapies and Genetic Landscape in Selected Rare Diseases with Hematologic Manifestations: A Review of the Literature., PMID:36766791
Activated granulocytes and inflammatory cytokine signaling drive T-cell lymphoma progression and disease symptoms., PMID:36696631
Functionally impaired antibody response to BNT162b2 booster vaccination in CVID IgG responders., PMID:36463978
Evaluation of tumor microenvironment and biomarkers of immune checkpoint inhibitor response in metastatic renal cell carcinoma., PMID:36252996
When to suspect inborn errors of immunity in Epstein-Barr virus-related lymphoproliferative disorders., PMID:36209991
Combination Approaches to Target PD-1 Signaling in Cancer., PMID:35911672
[New EMA approval: Nivolumab plus Cabozantinib for advanced renal clear cell carcinoma]., PMID:34538614
Primary Immune Regulatory Disorders With an Autoimmune Lymphoproliferative Syndrome-Like Phenotype: Immunologic Evaluation, Early Diagnosis and Management., PMID:34447369
Visualization of Host Cell Kinase Activation by Viral Proteins Using GFP Fluorescence Complementation and Immunofluorescence Microscopy., PMID:34327265
Assessing the pharmacokinetics of acalabrutinib in the treatment of chronic lymphocytic leukemia., PMID:34275396
BTK inhibitors, irrespective of ITK inhibition, increase efficacy of a CD19/CD3-bispecific antibody in CLL., PMID:34046681
Addition of BTK inhibitor orelabrutinib to rituximab improved anti-tumor effects in B cell lymphoma., PMID:33981831
Diagnostic significance of stromal changes in biopsies of prostate adenocarcinoma., PMID:33857855
SHP2 Targets ITK Downstream of PD-1 to Inhibit T Cell Function., PMID:33624224
Enhancing the Generation of Eomeshi CD8+ T Cells Augments the Efficacy of OX40- and CTLA-4-Targeted Immunotherapy., PMID:33593794
Dermatological Toxicities of Bruton's Tyrosine Kinase Inhibitors., PMID:32613545
Combining ibrutinib and checkpoint blockade improves CD8+ T-cell function and control of chronic lymphocytic leukemia in Em-TCL1 mice., PMID:32139435
N-glycopeptide Signatures of IgA2 in Serum from Patients with Hepatitis B Virus-related Liver Diseases., PMID:31501225
ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma., PMID:30814910
Oral direct-acting antiviral therapy for hepatitis C virus infection in X-linked agammaglobulinemia., PMID:30339854
Noncovalent inhibition of C481S Bruton tyrosine kinase by GDC-0853: a new treatment strategy for ibrutinib-resistant CLL., PMID:30018078
Terminal 14q32.33 deletion as a novel cause of agammaglobulinemia., PMID:28705765
Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+ CTLs., PMID:28213500
Lymphoma Secondary to Congenital and Acquired Immunodeficiency Syndromes at a Turkish Pediatric Oncology Center., PMID:27492260
IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma., PMID:25934889
Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK., PMID:25730880
Characterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target., PMID:25250764
Intracellular TCR-signaling pathway: novel markers for lymphoma diagnosis and potential therapeutic targets., PMID:25118816
A series of 4 cases of distinct keratopathy secondary to dysproteinemia: immunotactoid keratopathy., PMID:25103658
Toxic shock syndrome toxin-1-mediated toxicity inhibited by neutralizing antibodies late in the course of continual in vivo and in vitro exposure., PMID:24887085
Hematopoietic stem cell transplantation conditioning with use of rituximab in EBV related lymphoproliferative disorders., PMID:24584040
Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases., PMID:23982207
Neoplastic transformation of T lymphocytes through transgenic expression of a virus host modification protein., PMID:22558084
IL-2-inducible T-cell kinase deficiency with pulmonary manifestations due to disseminated Epstein-Barr virus infection., PMID:22487848
Chameleon-like appearance of immunotactoid keratopathy., PMID:21941171
[Expressions of receptor tyrosine kinases mRNA and protein in carcinoma of bladder]., PMID:21906447
[Follicular variant of peripheral T-cell lymphoma: a clinicopathologic and genetic study of 2 cases]., PMID:21429356
Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling., PMID:21245484
A phase I study of personalized peptide vaccination using 14 kinds of vaccine in combination with low-dose estramustine in HLA-A24-positive patients with castration-resistant prostate cancer., PMID:20878951
Influence of maternal gestational treatment with mycobacterial antigens on postnatal immunity in an experimental murine model., PMID:20300629
Tec protein tyrosine kinase inhibits CD25 expression in human T-lymphocyte., PMID:19883687
For research use only. Not for human or drug use.
