Catalog No.
RHF96501
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
IHC: 1:500
Target
DNA topoisomerase 2-beta, TOP2B, DNA topoisomerase II, beta isozyme
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q02880
Applications
IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3Q71
The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma., PMID:34753908
Etoposide and topoisomerase II inhibition for aggressive prostate cancer: Data from a translational study., PMID:33091733
Novel localizations and interactions of intercellular bridge proteins revealed by proteomic profiling†., PMID:31995159
Release of paused RNA polymerase II at specific loci favors DNA double-strand-break formation and promotes cancer translocations., PMID:31110352
Trastuzumab-mediated cardiotoxicity: current understanding, challenges, and frontiers., PMID:30215054
Identification of KIAA1210 as a novel X-chromosome-linked protein that localizes to the acrosome and associates with the ectoplasmic specialization in testes., PMID:28203736
Overexpression of Lewis(y) antigen protects ovarian cancer RMG-1 cells from carboplatin-induced apoptosis by the upregulation of Topo-I and Topo-II β., PMID:21542140
Targeting PKC delta-mediated topoisomerase II beta overexpression subverts the differentiation block in a retinoic acid-resistant APL cell line., PMID:20200558
Differential immunohistochemical staining for DNA topoisomerase II alpha and beta in human tissues and for DNA topoisomerase II beta in non-Hodgkin's lymphomas., PMID:9071722
Is DNA topoisomerase II beta a nucleolar protein?, PMID:8913868
Topoisomerase II activities in AML and their correlation with cellular sensitivity to anthracyclines and epipodophyllotoxines., PMID:8683999
For research use only. Not for human or drug use.
