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Anti-NFKB2 Antibody (R3Q17)

Catalog #:   RHF83102 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG1
Applications: ELISA, WB
Accession: Q00653
Overview

Catalog No.

RHF83102

Species reactivity

Human, Mouse

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

ELISA: 1:10000, WB: 1:500-1:2000

Target

Lymphocyte translocation chromosome 10 protein, NFKB2, LYT10, H2TF1, Nuclear factor NF-kappa-B p100 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, DNA-binding factor KBF2, Oncogene Lyt-10, Lyt10

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q00653

Applications

ELISA, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3Q17

Data Image
  • Western blot
    Western blot analysis using NFKB2 mouse mAb against NIH/3T3 (1), MCF-7 (2), and THP-1 (3) cell lysate.
References

The Burden of Non-Infectious Organ-Specific Immunopathology in Pediatric Common Variable Immunodeficiency., PMID:40141295

Mutational Landscape of Bone Marrow CD19 and CD138 Cells in Waldenström Macroglobulinemia (WM) and IgM Monoclonal Gammopathy of Undetermined Significance (IgM MGUS)., PMID:39711167

NF-ΚB Activation as a Key Driver in Chronic Lymphocytic Leukemia Evolution to Richter's Syndrome: Unraveling the Influence of Immune Microenvironment Dynamics., PMID:39596634

A Novel Heterozygous NFKB2 Variant in a Multiplex Family with Common Variable Immune Deficiency and Autoantibodies Against Type I IFNs., PMID:39579251

Type-Specific Impacts of Protein Defects in Pathogenic NFKB2 Variants: Novel Clinical Findings From 138 Patients., PMID:39447838

Clinical, Immunological, and Genetic Features in Patients with NFKB1 and NFKB2 Mutations: a Systematic Review., PMID:38990428

The Scope and Impact of Viral Infections in Common Variable Immunodeficiency (CVID) and CVID-like Disorders: A Literature Review., PMID:38541942

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency., PMID:37938781

TRIM55 promotes noncanonical NF-κB signaling and B cell-mediated immune responses by coordinating p100 ubiquitination and processing., PMID:37816088

Case Report: Mycosis fungoides as an exclusive manifestation of common variable immunodeficiency in a family with a NFKB2 gene mutation., PMID:37781189

Anti-complement 5 antibody ameliorates antibody-mediated rejection after liver transplantation in rats., PMID:37398677

Deficient anterior pituitary with common variable immune deficiency (DAVID syndrome): a new case and literature reports., PMID:37322808

Autoantibodies targeting type I interferons: Prevalence, mechanisms of induction, and association with viral disease susceptibility., PMID:37027328

NFKB2 haploinsufficiency identified via screening for IFN-α2 autoantibodies in children and adolescents hospitalized with SARS-CoV-2-related complications., PMID:36509151

Screening patients with autoimmune endocrine disorders for cytokine autoantibodies reveals monogenic immune deficiencies., PMID:36191466

Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa., PMID:35916405

Identifying predictive signalling networks for Vedolizumab response in ulcerative colitis., PMID:35543875

Establishing the Molecular Diagnoses in a Cohort of 291 Patients With Predominantly Antibody Deficiency by Targeted Next-Generation Sequencing: Experience From a Monocentric Study., PMID:34975878

Disseminated Coccidioidomycosis as the First Presentation of a C-Terminal NFKB2 Pathogenic Variant: A Case Report and Review of the Literature., PMID:34609106

Late-Onset Isolated Corticotrope Deficiency in a Woman with Down Syndrome., PMID:34007493

T and B Lymphocyte Transcriptional States Differentiate between Sensitized and Unsensitized Individuals in Alpha-Gal Syndrome., PMID:33804792

Serum microRNAs as Tool to Predict Early Response to Benralizumab in Severe Eosinophilic Asthma., PMID:33525548

Severe SARS-CoV-2 disease in the context of a NF-κB2 loss-of-function pathogenic variant., PMID:33007327

Correction to: A Nonsense N -Terminus NFKB2 Mutation Leading to Haploinsufficiency in a Patient with a Predominantly Antibody Deficiency., PMID:32901356

A Nonsense N -Terminus NFKB2 Mutation Leading to Haploinsufficiency in a Patient with a Predominantly Antibody Deficiency., PMID:32813180

TRAF3 Acts as a Checkpoint of B Cell Receptor Signaling to Control Antibody Class Switch Recombination and Anergy., PMID:32591397

Heterogeneity of Liver Disease in Common Variable Immunodeficiency Disorders., PMID:32184784

NFKB2 polymorphisms associate with the risk of developing rheumatoid arthritis and response to TNF inhibitors: Results from the REPAIR consortium., PMID:32152480

Signature of genome wide gene expression in classical swine fever virus infected macrophages and PBMCs of indigenous vis-a-vis crossbred pigs., PMID:31935504

Endocrine Disorders Are Prominent Clinical Features in Patients With Primary Antibody Deficiencies., PMID:31543881

Familial hypogammaglobulinemia with high RTE and naïve T lymphocytes., PMID:31468084

Pathogenic NFKB2 variant in the ankyrin repeat domain (R635X) causes a variable antibody deficiency., PMID:30953794

Severe Facial Herpes Vegetans and Viremia in NFKB2-Deficient Common Variable Immunodeficiency., PMID:30941333

Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in NFKB2., PMID:30941118

Inherited Immunodeficiency: A New Association With Early-Onset Childhood Panniculitis., PMID:29610179

Anticytokine autoantibodies in a patient with a heterozygous NFKB2 mutation., PMID:29225085

MKK4 activates non-canonical NFκB signaling by promoting NFκB2-p100 processing., PMID:28733031

A Case Report of Hypoglycemia and Hypogammaglobulinemia: DAVID Syndrome in a Patient With a Novel NFKB2 Mutation., PMID:28472507

Transcription factors of the alternative NF-κB pathway are required for germinal center B-cell development., PMID:27457956

Genes associated with common variable immunodeficiency: one diagnosis to rule them all?, PMID:27250108

RAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals., PMID:26834154

Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr/lpr) mutant mice., PMID:26084385

Effects of Pholiota nameko polysaccharide on NF-κB pathway of murine bone marrow-derived dendritic cells., PMID:25812973

Transcriptome analysis of medaka following epinecidin-1 and TH1-5 treatment of NNV infection., PMID:25449377

Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100., PMID:25237204

Transcription factors involved in prostate gland adaptation to androgen deprivation., PMID:24886974

Germline mutations in NFKB2 implicate the noncanonical NF-κB pathway in the pathogenesis of common variable immunodeficiency., PMID:24140114

p53 mutants induce transcription of NF-κB2 in H1299 cells through CBP and STAT binding on the NF-κB2 promoter and gain of function activity., PMID:22198284

The nuclear-factor kappaB pathway is activated in pterygium., PMID:20811049

Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma., PMID:17692805

Datasheet

Document Download

Anti-NFKB2 Antibody (R3Q17).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

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Anti-NFKB2 Antibody (R3Q17) [RHF83102]
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