Catalog No.
RHF68701
Species reactivity
Human
Host species
Mouse
Isotype
IgG2b
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IP: 1:20, WB: 1:500-1:1000
Target
DNPK1, HYRC1, p460, DNA-dependent protein kinase catalytic subunit, PRKDC, DNA-PK catalytic subunit, HYRC, DNA-PKcs
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P78527
Applications
IF, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.5% BSA, 0.05% Sodium Azide and 50% Glycerol.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3P81
Oncolytic adenovirus H101 enhances the anti-tumor effects of PD-1 blockade via CD47 downregulation in tumor cells., PMID:40296909
Humanized mouse model reveals the immunogenicity of Hepatitis B Virus vaccine candidates produced in CRISPR/Cas9-edited Nicotiana benthamiana., PMID:40270959
Tick salivary proteins metalloprotease and allergen-like p23 are associated with response to glycan α-Gal and mycobacterium infection., PMID:40087469
High-Throughput Dissociation and Orthotopic Implantation of Breast Cancer Patient-Derived Xenografts., PMID:39760370
Human circulating CD24hi marginal zone B cells produce IgM targeting atherogenic antigens and confer protection from vascular disease., PMID:39196097
Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice., PMID:38746102
PANoptosis Features, a Humanized NSG Murine Model of Sjogren's Syndrome., PMID:38635961
Enhanced potency of immunotherapy against B-cell precursor acute lymphoblastic leukemia by combination of an Fc-engineered CD19 antibody and CD47 blockade., PMID:38435424
Characterization of novel, severely immunodeficient PrkdcΔex57/Δex57 mice., PMID:37651888
A novel PRKDC mutation caused B lymphocytes V(D)J rearrangement disorder in the SLE-DAH like symptoms patient., PMID:37580814
Chemokine Receptors CCR6 and PD1 Blocking scFv E27 Enhances Anti-EGFR CAR-T Therapeutic Efficacy in a Preclinical Model of Human Non-Small Cell Lung Carcinoma., PMID:36982500
Infectivity and Shedding of Mouse Kidney Parvovirus After Oronasal Inoculation of C57BL/6, CD1, and NSG Mice., PMID:36744512
Tissue proteome analysis revealed an association between cancer, immune system response, and the idiopathic granulomatous mastitis., PMID:36175807
Spontaneous xenogeneic GvHD in Wilms' tumor Patient-Derived xenograft models and potential solutions., PMID:35726155
Visualizing surface marker expression and intratumoral heterogeneity with SERRS-NPs imaging., PMID:35145836
Annotating BCMA Expression in Multiple Myelomas., PMID:34843261
Targeting TfR1 with the ch128.1/IgG1 Antibody Inhibits EBV-driven Lymphomagenesis in Immunosuppressed Mice Bearing EBV+ Human Primary B-cells., PMID:34158342
X-ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double-strand break repair impacting cell and cancer biology., PMID:34056803
Nanoencapsulated rituximab mediates superior cellular immunity against metastatic B-cell lymphoma in a complement competent humanized mouse model., PMID:33593826
Association Between DNA Damage Response, Fibrosis and Type I Interferon Signature in Systemic Sclerosis., PMID:33123169
DNA-PKcs Inhibition Extends Allogeneic Skin Graft Survival., PMID:32890138
Serendipitous Discovery of a Novel Murine Astrovirus Contaminating a Murine Helper T-cell Line and Incapable of Infecting Highly Immunodeficient Mice., PMID:32674749
Relationship between thyroid tumor radiosensitivity and nuclear localization of DNA-dependent protein kinase catalytic subunit., PMID:32567663
PRKDC: new biomarker and drug target for checkpoint blockade immunotherapy., PMID:32238472
The EGFL7-ITGB3-KLF2 axis enhances survival of multiple myeloma in preclinical models., PMID:32191808
Anti-tumor effects of anti-PD-1 antibody, pembrolizumab, in humanized NSG PDX mice xenografted with dedifferentiated liposarcoma., PMID:32145342
DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G2-checkpoint in S-phase irradiated cells., PMID:31601897
Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity., PMID:31332184
Development of a Novel Anti-CD19 Chimeric Antigen Receptor: A Paradigm for an Affordable CAR T Cell Production at Academic Institutions., PMID:30623002
Sensitivity of CD3/CD28-stimulated versus non-stimulated lymphocytes to ionizing radiation and genotoxic anticancer drugs: key role of ATM in the differential radiation response., PMID:30323167
Two siblings with PRKDC defect who presented with cutaneous granulomas and review of the literature., PMID:30121298
Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination., PMID:30072430
Assessment of DNA-PKcs kinase activity by quantum dot-based microarray., PMID:30030458
Donor tissue-specific exosome profiling enables noninvasive monitoring of acute rejection in mouse allogeneic heart transplantation., PMID:29499866
ILT3.Fc-CD166 Interaction Induces Inactivation of p70 S6 Kinase and Inhibits Tumor Cell Growth., PMID:29263213
Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy., PMID:29146734
A Naturally Transmitted Epitheliotropic Polyomavirus Pathogenic in Immunodeficient Rats: Characterization, Transmission, and Preliminary Epidemiologic Studies., PMID:28782456
An Fc-engineered CD19 antibody eradicates MRD in patient-derived MLL-rearranged acute lymphoblastic leukemia xenografts., PMID:28698205
Effects of DNA end configuration on XRCC4-DNA ligase IV and its stimulation of Artemis activity., PMID:28696258
Humanized CD7 nanobody-based immunotoxins exhibit promising anti-T-cell acute lymphoblastic leukemia potential., PMID:28331319
Esophageal Adenocarcinoma Cells and Xenograft Tumors Exposed to Erb-b2 Receptor Tyrosine Kinase 2 and 3 Inhibitors Activate Transforming Growth Factor Beta Signaling, Which Induces Epithelial to Mesenchymal Transition., PMID:28286209
[Effects and its mechanism of Nimotuzumab on radiosensitivity of esophageal carcinoma ECA-109 and TE-13 cell lines]., PMID:27784455
Attenuation of graft-versus-host-disease in NOD scid IL-2Rγ(-/-) (NSG) mice by ex vivo modulation of human CD4(+) T cells., PMID:27560708
Downregulation of DNA-PKcs suppresses P-gp expression via inhibition of the Akt/NF-κB pathway in CD133-positive osteosarcoma MG-63 cells., PMID:27499034
Cell Killing Mechanisms and Impact on Gene Expression by Gemcitabine and 212Pb-Trastuzumab Treatment in a Disseminated i.p. Tumor Model., PMID:27467592
Cronkhite Canada Syndrome: Significant Response to Infliximab and a Possible Clue to Pathogenesis., PMID:27151126
Isolation of Pancreatic Cancer Cells from a Patient-Derived Xenograft Model Allows for Practical Expansion and Preserved Heterogeneity in Culture., PMID:27102771
CD47-SIRPα Interactions Regulate Macrophage Uptake of Plasmodium falciparum-Infected Erythrocytes and Clearance of Malaria In Vivo., PMID:27091932
Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle Arrest., PMID:27026501
Transcriptional elongation requires DNA break-induced signalling., PMID:26671524
For research use only. Not for human or drug use.
