Anti-ARF6 Antibody (R3P06)

Catalog No.

RHF51002

Species reactivity

Human

Host species

Mouse

Isotype

IgG2b

Clonality

Monoclonal

Tested applications

IHC: 1:20-1:100

Target

ARF6, ADP-ribosylation factor 6

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P62330

Applications

IHC

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3P06

The Arf pathway is required for resolving ER stress during T cell activation., PMID:40405457

Relationship between autoimmunity and COPD: an investigation based on proteomic profiling and antinuclear antibody screening., PMID:40329569

ADP-Ribosylation Factor 6 Pathway Acts as a Key Executor of Mesenchymal Tumor Plasticity., PMID:37834383

ADP Ribosylation Factor 6 Relieves Airway Inflammation and Remodeling by Inhibiting Ovalbumin Induced-Epithelial Mesenchymal Transition in Experimental Asthma, Possibly by Regulating of E2F Transcription Factor 8., PMID:37326141

Impaired Autophagy Response in Hepatocellular Carcinomas Enriches Glypican-3 in Exosomes, Not in the Microvesicles., PMID:36105695

A comprehensive analysis of different gene classes in pancreatic cancer: SIGLEC15 may be a promising immunotherapeutic target., PMID:34515878

Inhibition of mutant KRAS-driven overexpression of ARF6 and MYC by an eIF4A inhibitor drug improves the effects of anti-PD-1 immunotherapy for pancreatic cancer., PMID:34001163

In vivo mapping of a GPCR interactome using knockin mice., PMID:32457152

CD13 tethers the IQGAP1-ARF6-EFA6 complex to the plasma membrane to promote ARF6 activation, β1 integrin recycling, and cell migration., PMID:31040262

Endocytic Recycling of MHC Class I Molecules in Non-professional Antigen Presenting and Dendritic Cells., PMID:30666258

Humanized anti-CD123 antibody facilitates NK cell antibody-dependent cell-mediated cytotoxicity (ADCC) of Hodgkin lymphoma targets via ARF6/PLD-1., PMID:30647406

The breast cancer antigen 5T4 interacts with Rab11, and is a target and regulator of Rab11 mediated trafficking., PMID:29549047

Arf6 in lymphatic endothelial cells regulates lymphangiogenesis by controlling directional cell migration., PMID:28900118

Cellular and subcellular localization of ADP-ribosylation factor 6 in mouse peripheral tissues., PMID:28748255

BRAG2a, a Guanine Nucleotide Exchange Factor for Arf6, Is a Component of the Dystrophin-Associated Glycoprotein Complex at the Photoreceptor Terminal., PMID:28744553

Arf6 and Rab22 mediate T cell conjugate formation by regulating clathrin-independent endosomal membrane trafficking., PMID:28584192

Endocytic uptake of monomeric amyloid-β peptides is clathrin- and dynamin-independent and results in selective accumulation of Aβ(1-42) compared to Aβ(1-40)., PMID:28515429

Inhibition of epithelial-mesenchymal transition by cetuximab via the EGFR-GEP100-Arf6-AMAP1 pathway in head and neck cancer., PMID:27880014

Pdlim7 Regulates Arf6-Dependent Actin Dynamics and Is Required for Platelet-Mediated Thrombosis in Mice., PMID:27792740

Distinct subcellular localization of alternative splicing variants of EFA6D, a guanine nucleotide exchange factor for Arf6, in the mouse brain., PMID:27241101

Which Way In? The RalF Arf-GEF Orchestrates Rickettsia Host Cell Invasion., PMID:26291822

Increased expression of ARF GTPases in prostate cancer tissue., PMID:26185744

Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes., PMID:26170135

Cytohesin-2 phosphorylation by protein kinase C relieves the constitutive suppression of platelet dense granule secretion by ADP-ribosylation factor 6., PMID:24581425

Endocytosis of HERG is clathrin-independent and involves arf6., PMID:24392021

Co-overexpression of GEP100 and AMAP1 proteins correlates with rapid local recurrence after breast conservative therapy., PMID:24116160

Uptake of advanced glycation end products by proximal tubule epithelial cells via macropinocytosis., PMID:23747564

Epstein-Barr virus transcytosis through polarized oral epithelial cells., PMID:23698302

Noradrenaline induces binding of Clathrin light chain A to α1-adrenoceptors in the human prostate., PMID:23460120

Syndecan-4 phosphorylation is a control point for integrin recycling., PMID:23453597

Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development., PMID:23012656

Arf6 promotes autophagosome formation via effects on phosphatidylinositol 4,5-bisphosphate and phospholipase D., PMID:22351926

ADP ribosylation factor 1 activity is required to recruit AP-1 to the major histocompatibility complex class I (MHC-I) cytoplasmic tail and disrupt MHC-I trafficking in HIV-1-infected primary T cells., PMID:21917951

Arf6 regulates AP-1B-dependent sorting in polarized epithelial cells., PMID:21911479

Cytohesin-1 regulates human blood neutrophil adhesion to endothelial cells through β2 integrin activation., PMID:21511340

Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 β-cells and rat islets., PMID:21276423

H-ras resides on clathrin-independent ARF6 vesicles that harbor little RAF-1, but not on clathrin-dependent endosomes., PMID:21145357

Tissue- and development-dependent expression of the small GTPase Arf6 in mice., PMID:21069828

Reversible bleb formation in mast cells stimulated with antigen is Ca2+/calmodulin-dependent and bleb size is regulated by ARF6., PMID:19845506

ERK MAP kinase-activated Arf6 trafficking directs coxsackievirus type B3 into an unproductive compartment during virus host-cell entry., PMID:19264606

A-RAF kinase functions in ARF6 regulated endocytic membrane traffic., PMID:19247477

ARF6 Interacts with JIP4 to control a motor switch mechanism regulating endosome traffic in cytokinesis., PMID:19211056

Localization of EFA6A, a guanine nucleotide exchange factor for ARF6, in spermatogenic cells of testes of adult mice., PMID:19085064

Predominant localization of EFA6A, a guanine nucleotide exchange factor for ARF6, at the perisynaptic photoreceptor processes., PMID:18708035

Uncommon endocytic and trafficking pathway of the natural killer cell CD94/NKG2A inhibitory receptor., PMID:18363778

A role for EHD4 in the regulation of early endosomal transport., PMID:18331452

The N-terminal coiled-coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with Galphaq., PMID:17846866

Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity., PMID:17562860

Somatodendritic localization of EFA6A, a guanine nucleotide exchange factor for ADP-ribosylation factor 6, and its possible interaction with alpha-actinin in dendritic spines., PMID:17298598

Phagocytosis of Leishmania donovani amastigotes is Rac1 dependent and occurs in the absence of NADPH oxidase activation., PMID:16955522

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