Catalog No.
RHF05103
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
IHC: 1:200-1:1000
Target
Hepatoma transmembrane kinase, Tyrosine-protein kinase TYRO11, HTK, EPHB4, Ephrin type-B receptor 4, TYRO11, MYK1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P54760
Applications
IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3N27
Decompensated liver failure due to portal hypertension as a result of hepatic arteriovenous malformations., PMID:40194806
Expression Profiles of Five Common Cancer Membrane Protein Antigens Collected for the Development of Cocktail CAR-T Cell Therapies Applicable to Most Solid Cancer Patients., PMID:40076777
The pro-tumoral and anti-tumoral roles of EphA4 on T regulatory cells and tumor associated macrophages during HNSCC tumor progression., PMID:39211197
Improved efficacy of pembrolizumab combined with soluble EphB4-albumin in HPV-negative EphrinB2 positive head neck squamous cell carcinoma., PMID:38985143
Treatment for Gorham-Stout syndrome with a combination of teriparatide and denosumab., PMID:38062162
Development of an Anti-EphB4 Monoclonal Antibody for Multiple Applications Against Breast Cancers., PMID:37824755
EphrinB2: Expression of a novel potential target in renal cell carcinoma., PMID:37575160
Histochemical assessment of osteoclast-like giant cells in Rankl-/- mice., PMID:37088151
May EPH/Ephrin Targeting Revolutionize Lung Cancer Treatment?, PMID:36613532
EphrinB2 Inhibition and Pembrolizumab in Metastatic Urothelial Carcinoma., PMID:35984996
ED-71 inhibited osteoclastogenesis by enhancing EphrinB2-EphB4 signaling between osteoclasts and osteoblasts in osteoporosis., PMID:35690294
EphB4 as a Novel Target for the EGFR-Independent Suppressive Effects of Osimertinib on Cell Cycle Progression in Non-Small Cell Lung Cancer., PMID:34445227
Tyrosine Phosphoproteomics of Patient-Derived Xenografts Reveals Ephrin Type-B Receptor 4 Tyrosine Kinase as a Therapeutic Target in Pancreatic Cancer., PMID:34298619
BMP2 immune complexes promote new bone formation by facilitating the direct contact between osteoclasts and osteoblasts., PMID:34130144
The protective role of Ephrin-B2/EphB4 signaling in osteogenic differentiation under inflammatory environment., PMID:33516666
Non-invasive Embryo Assessment: Altered Individual Protein Profile in Spent Culture Media from Embryos Transferred at Day 5., PMID:33151525
Evaluating genomic biomarkers associated with resistance or sensitivity to chemotherapy in patients with advanced breast and colorectal cancer., PMID:32847480
Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways., PMID:32694189
The role of Eph receptors in cancer and how to target them: novel approaches in cancer treatment., PMID:32348169
EphB4/ TNFR2/ERK/MAPK signaling pathway comprises a signaling axis to mediate the positive effect of TNF-α on osteogenic differentiation., PMID:32299362
Bidirectional ephrinB2‑EphB4 signaling regulates the osteogenic differentiation of canine periodontal ligament stem cells., PMID:31985015
Resistance to bevacizumab in ovarian cancer SKOV3 xenograft due to EphB4 overexpression., PMID:31898661
Immunohistochemical assessment of Eph/ephrin expression in oral squamous cell carcinoma and precursor lesions., PMID:31654153
Vascular Endothelial Receptor Tyrosine Phosphatase: Identification of Novel Substrates Related to Junctions and a Ternary Complex with EPHB4 and TIE2., PMID:31427368
Pancreatic Tumor Microenvironment Modulation by EphB4-ephrinB2 Inhibition and Radiation Combination., PMID:30944125
RANKL, Ephrin-Eph and Wnt10b are key intercellular communication molecules regulating bone remodeling in autologous transplanted goldfish scales., PMID:29886255
Inhibition of EphB4-Ephrin-B2 Signaling Enhances Response to Cetuximab-Radiation Therapy in Head and Neck Cancers., PMID:29848571
Prognostic Value of ACVRL1 Expression in Metastatic Colorectal Cancer Patients Receiving First-line Chemotherapy With Bevacizumab: Results From the Triplet Plus Bevacizumab (TRIBE) Study., PMID:29636300
EPHB4 is a therapeutic target in AML and promotes leukemia cell survival via AKT., PMID:29296810
EphB4/EphrinB2 therapeutics in Rhabdomyosarcoma., PMID:28817624
Right- vs. Left-Sided Metastatic Colorectal Cancer: Differences in Tumor Biology and Bevacizumab Efficacy., PMID:28598398
Circulating VEGF and eNOS variations as predictors of outcome in metastatic colorectal cancer patients receiving bevacizumab., PMID:28465540
Extravillous trophoblast invasion of venous as well as lymphatic vessels is altered in idiopathic, recurrent, spontaneous abortions., PMID:28369440
Characterization of arteriovenous identity in the developing neonate mouse retina., PMID:28167138
Evaluation of EphA2 and EphB4 as Targets for Image-Guided Colorectal Cancer Surgery., PMID:28165374
Sinusoidal ephrin receptor EPHB4 controls hematopoietic progenitor cell mobilization from bone marrow., PMID:27820703
Expression of Genes Involved in Vascular Morphogenesis and Maturation Predicts Efficacy of Bevacizumab-Based Chemotherapy in Patients Undergoing Liver Resection., PMID:27535973
Dual microRNA Screens Reveal That the Immune-Responsive miR-181 Promotes Henipavirus Entry and Cell-Cell Fusion., PMID:27783670
Formation of vascular network structures within cardiac cell sheets from mouse embryonic stem cells., PMID:31245454
Development of a Trispecific Antibody Designed to Simultaneously and Efficiently Target Three Different Antigens on Tumor Cells., PMID:26176328
EphB4 forward signalling regulates lymphatic valve development., PMID:25865237
Anti-tumour effects of antibodies targeting the extracellular cysteine-rich region of the receptor tyrosine kinase EphB4., PMID:25831049
EphB4 expression in pterygium is associated with microvessel density., PMID:25550909
Ephrin type-B receptor 4 activation reduces neointimal hyperplasia in human saphenous vein in vitro., PMID:25446283
Arterial shear stress reduces eph-b4 expression in adult human veins., PMID:25191151
The differential expression of EphB2 and EphB4 receptor kinases in normal bladder and in transitional cell carcinoma of the bladder., PMID:25148033
EphB4-targeted imaging with antibody h131, h131-F(ab')2 and h131-Fab., PMID:24147882
Dual-modality micro-positron emission tomography/computed tomography and near-infrared fluorescence imaging of EphB4 in orthotopic glioblastoma xenograft models., PMID:23918654
EphB4 as a therapeutic target in mesothelioma., PMID:23721559
EphrinB2-EphB4 signals regulate formation and maintenance of funnel-shaped valves in corneal lymphatic capillaries., PMID:23696610
For research use only. Not for human or drug use.
