Catalog No.
RHE93302
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400
Target
VAV2, VAV-2, Guanine nucleotide exchange factor VAV2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P52735
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3M91
Genetic regulation of B cell receptor signaling pathway: Insights from expression quantitative trait locus analysis using a mixed model., PMID:39236423
CD64+ fibroblast-targeted vilanterol and a STING agonist augment CLDN18.2 BiTEs efficacy against pancreatic cancer by reducing desmoplasia and enriching stem-like CD8+ T cells., PMID:39187291
Aberrant B-Cell Activation in Systemic Lupus Erythematosus., PMID:36590680
CD16+ fibroblasts foster a trastuzumab-refractory microenvironment that is reversed by VAV2 inhibition., PMID:36379207
Genetic Basis of Response of Ghanaian Local Chickens to Infection With a Lentogenic Newcastle Disease Virus., PMID:32849779
Vav family proteins constitute disparate branching points for distinct BCR signaling pathways., PMID:32671844
A Novel Vav3 Homolog Identified in Lamprey, Lampetra japonica, with Roles in Lipopolysaccharide-Mediated Immune Response., PMID:28937614
Copy number variations of HLA-I and activation of NKp30 pathway determine the sensitivity of gastric cancer cells to the cytotoxicity of natural killer cells., PMID:26364607
HIF1A regulates xenophagic degradation of adherent and invasive Escherichia coli (AIEC)., PMID:25484075
The signalling factor PI3K is a specific regulator of the clathrin-independent dynamin-dependent endocytosis of IL-2 receptors., PMID:23345407
Small GTPases Rap1 and RhoA regulate superoxide formation by Rac1 GTPases activation during the phagocytosis of IgG-opsonized zymosans in macrophages., PMID:22330068
CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells., PMID:22262777
VE-cadherin trans-interactions modulate Rac activation and enhancement of lung endothelial barrier by iloprost., PMID:22213015
RhoB links PDGF signaling to cell migration by coordinating activation and localization of Cdc42 and Rac., PMID:21344485
Syk mediates BCR- and CD40-signaling integration during B cell activation., PMID:21074890
Filamin B plays a key role in vascular endothelial growth factor-induced endothelial cell motility through its interaction with Rac-1 and Vav-2., PMID:20110358
Therapeutic IMC-C225 antibody inhibits breast cancer cell invasiveness via Vav2-dependent activation of RhoA GTPase., PMID:18829495
RNA interference screen identifies Abl kinase and PDGFR signaling in Chlamydia trachomatis entry., PMID:18369471
Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation., PMID:18191593
Strongly reduced alloreactivity and long-term survival times of cardiac allografts in Vav1- and Vav1/Vav2-knockout mice., PMID:17326776
PTP-PEST couples membrane protrusion and tail retraction via VAV2 and p190RhoGAP., PMID:16513648
Synergistic activation of PKD by the B cell antigen receptor and CD19 requires PI3K, Vav1 and PLCgamma., PMID:16380231
The P2Y2 nucleotide receptor interacts with alphav integrins to activate Go and induce cell migration., PMID:16186116
Murine gamma-herpesvirus 68 latency protein M2 binds to Vav signaling proteins and inhibits B-cell receptor-induced cell cycle arrest and apoptosis in WEHI-231 B cells., PMID:16150693
Vav proteins regulate peripheral B-cell survival., PMID:15941910
Vav proteins are required for B-lymphocyte responses to LPS., PMID:15811961
The adaptor protein 3BP2 associates with VAV guanine nucleotide exchange factors to regulate NFAT activation by the B-cell antigen receptor., PMID:15345594
Erk1/2- and p38 MAP kinase-dependent phosphorylation and activation of cPLA2 by m3 and m2 receptors., PMID:12576304
Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line., PMID:12234921
Defective CD19-dependent signaling in B-1a and B-1b B lymphocyte subpopulations., PMID:12213328
B-cell development and antigen receptor signalling., PMID:12196204
Vav3 is regulated during the cell cycle and effects cell division., PMID:11917103
Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent., PMID:11896053
Vav1 couples T cell receptor to serum response factor-dependent transcription via a MEK-dependent pathway., PMID:11859076
Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth., PMID:11606575
Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling., PMID:11376343
Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation., PMID:11376342
Vav and the B cell signalosome., PMID:11376331
Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes., PMID:11080163
Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function., PMID:11079101
Vav family proteins couple to diverse cell surface receptors., PMID:10938113
Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav., PMID:10669745
For research use only. Not for human or drug use.
