Catalog No.
RHE91801
Species reactivity
Human, Mouse
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
FCM: 1:200-1:400, IF: 1:200-1:1000, WB: 1:500-1:2000
Target
L-JAK, Janus kinase 3, Leukocyte janus kinase, JAK-3, Tyrosine-protein kinase JAK3, JAK3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P52333
Applications
FCM, IF, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3M78
Biological and Clinical Relevance of Genetic Alterations in Peripheral T-cell Lymphomas., PMID:40416001
JAK3 A573V and JAK3 M511I mutations in peripheral T-cell lymphoma mediating resistance to anti-PD-1 therapy through the STAT3/PD-L1 pathway., PMID:40199606
Modulating IL-21-driven B cell responses in idiopathic inflammatory myopathies via inhibition of the JAK/STAT pathway., PMID:40170058
Interaction between interleukin-12 (IL-12) and its receptor (IL-12Rβ2) mediates CD4+ T cell subsets activation in flounder (Paralichthys olivaceus)., PMID:39743087
The Innate Immune System Surveillance Biomarker p87 in African Americans and Caucasians with Small High-Grade Dysplastic Adenoma [SHiGDA] and Right-Sided JAK3 Colon Mutations May Explain the Presence of Multiple Cancers Revealing an Important Minority of Patients with JAK3 Mutations and Colorectal Neoplasia., PMID:39507544
Genes deregulated in giant cell arteritis by Nanostring nCounter gene expression profiling in temporal artery biopsies., PMID:39317454
The JAK1/JAK2 inhibitor ruxolitinib inhibits mediator release from human basophils and mast cells., PMID:39188724
Omenn Syndrome in Two Infants with Different Hypomorphic Variants in Janus Kinase 3., PMID:38598033
Effectiveness of tofacitinib monotherapy for patients with IgG4-RD or idiopathic retroperitoneal fibrosis., PMID:38530663
Radical S-adenosyl methionine domain-containing 2, a potential target of D-tryptophan in asthma treatment, regulates T helper cell type 1/2 balance., PMID:38310765
Suppression of NK Cell Activation by JAK3 Inhibition: Implication in the Treatment of Autoimmune Diseases., PMID:38106519
JAK3 Y841 Autophosphorylation Is Critical for STAT5B Activation, Kinase Domain Stability and Dimer Formation., PMID:37569303
A novel cDNA-uPA/SCID/Rag2-/- /Jak3-/- mouse model for hepatitis virus infection and reconstruction of human immune system., PMID:36575861
CXCL16 inhibits epithelial regeneration and promotes fibrosis during the progression of radiation enteritis., PMID:36373877
CS12192, a Novel JAK3/JAK1/TBK1 Inhibitor, Synergistically Enhances the Anti-Inflammation Effect of Methotrexate in a Rat Model of Rheumatoid Arthritis., PMID:36362183
IL-7: Comprehensive review., PMID:36201890
Clinicopathologic and Genomic Features in Triple-Negative Breast Cancer Between Special and No-Special Morphologic Pattern., PMID:35402236
A novel intramolecular negative regulation of mouse Jak3 activity by tyrosine 820., PMID:35192696
Tumor necrosis factor alpha neutralization attenuates immune checkpoint inhibitor-induced activation of intermediate monocytes in synovial fluid mononuclear cells from patients with inflammatory arthritis., PMID:35164829
Defects in mucosal immunity and nasopharyngeal dysbiosis in HSC-transplanted SCID patients with IL2RG/JAK3 deficiency., PMID:35157765
T Cell Repertoire Abnormality in Immunodeficiency Patients with DNA Repair and Methylation Defects., PMID:34825286
Immune cells surveil aberrantly sialylated O-glycans on megakaryocytes to regulate platelet count., PMID:34324649
Anti-IL-23 exerted protective effects on cerebral ischemia-reperfusion injury through JAK2/STAT3 signaling pathway., PMID:33904141
Recurrent Chronic HEV in Severe Combined Immunodeficiency., PMID:33619683
Upadacitinib in Rheumatoid Arthritis: A Benefit-Risk Assessment Across a Phase III Program., PMID:33527177
Qingxue jiedu formulation ameliorated DNFB-induced atopic dermatitis by inhibiting STAT3/MAPK/NF-κB signaling pathways., PMID:33388430
Combination of anti-PD-1 antibody with P-GEMOX as a potentially effective immunochemotherapy for advanced natural killer/T cell lymphoma., PMID:33376237
Increased expression of interleukin-21-inducible genes in minor salivary glands are associated with primary Sjögren's syndrome disease characteristics., PMID:33247940
Deep phenotyping of synovial molecular signatures by integrative systems analysis in rheumatoid arthritis., PMID:33230538
Molecular basis and therapeutic implications of CD40/CD40L immune checkpoint., PMID:33091428
The Natural Compound Notopterol Binds and Targets JAK2/3 to Ameliorate Inflammation and Arthritis., PMID:32937124
Efficacy and Safety of PF-06651600 (Ritlecitinib), a Novel JAK3/TEC Inhibitor, in Patients With Moderate-to-Severe Rheumatoid Arthritis and an Inadequate Response to Methotrexate., PMID:32419304
Ulcerative colitis: understanding its cellular pathology could provide insights into novel therapies., PMID:32336953
Monozygotic Twins Concordant for Common Variable Immunodeficiency: Strikingly Similar Clinical and Immune Profile Associated With a Polygenic Burden., PMID:31824477
Autocrine Production of Interleukin-34 Promotes the Development of Endometriosis through CSF1R/JAK3/STAT6 signaling., PMID:31727934
Targeted blockade of interleukin 9 inhibits tumor growth in murine model of pancreatic cancer., PMID:31647203
Therapeutic treatment of a novel selective JAK3/JAK1/TBK1 inhibitor, CS12192, in rat and mouse models of rheumatoid arthritis., PMID:31634789
IL-7-Mediated IL-7R-JAK3/STAT5 signalling pathway contributes to chemotherapeutic sensitivity in non-small-cell lung cancer., PMID:31599032
IL-2 receptors preassemble and signal in the ER/Golgi causing resistance to antiproliferative anti-IL-2Rα therapies., PMID:31570576
Assessment of the genes and molecular mechanisms of B cells activation through systems biology approaches., PMID:31524152
The γc Family of Cytokines: Basic Biology to Therapeutic Ramifications., PMID:30995502
Tumor-specific delivery of therapeutic siRNAs by anti-EGFR immunonanoparticles., PMID:30214190
Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma., PMID:30054295
Tofacitinib Halts Progression of Graft Dysfunction in a Rat Model of Mixed Cellular and Humoral Rejection., PMID:29620612
ILC2 frequency and activity are inhibited by glucocorticoid treatment via STAT pathway in patients with asthma., PMID:29542140
[Emerging Therapies: What Are Promising in the Near Future?]., PMID:29471605
Immunologic effects of chronic administration of tofacitinib, a Janus kinase inhibitor, in cynomolgus monkeys and rats - Comparison of juvenile and adult responses., PMID:29454012
Advances in the understanding and management of T-cell prolymphocytic leukemia., PMID:29262669
STAT5B: A Differential Regulator of the Life and Death of CD4+ Effector Memory T Cells., PMID:29187589
A gene module associated with dysregulated TCR signaling pathways in CD4+ T cell subsets in rheumatoid arthritis., PMID:29146547
For research use only. Not for human or drug use.
