Catalog No.
RHE84004
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000, IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
MeCp2, MeCp-2 protein, Methyl-CpG-binding protein 2, MECP2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P51608
Applications
ELISA, FCM, IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3M55
Jieyu Guben decoction alleviates combined allergic rhinitis and asthma syndrome by balancing Th17/Treg expression and restoring PPARD., PMID:40031093
Rett syndrome complicated by diabetes mellitus type 1., PMID:39907555
Response to Prof. Robert Colebunders' Letter submitted to JNS regarding: Spencer PS, Valdes Angues R, Palmer VS. Nodding syndrome: A role for environmental biotoxins that dysregulate MECP2 expression? J Neurol Sci. 2024 Jul 15;462:123077. doi: 10.1016/j.jns.2024.123077., PMID:39117466
Autoimmune and neuropsychiatric phenotypes in a Mecp2 transgenic mouse model on C57BL/6 background., PMID:38524134
In-depth comparison of Anc80L65 and AAV9 retinal targeting and characterization of cross-reactivity to multiple AAV serotypes in humans., PMID:37746244
Allele-Specific Epigenetic Regulation of FURIN Expression at a Coronary Artery Disease Susceptibility Locus., PMID:37443715
Mu opioid receptor expressing neurons in the rostral ventromedial medulla are the source of mechanical hypersensitivity induced by repeated restraint stress., PMID:37331575
Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart., PMID:37101286
A single-cell atlas reveals the heterogeneity of meningeal immunity in a mouse model of Methyl CpG binding protein 2 deficiency., PMID:36703978
The Cell Adhesion Molecule L1 Interacts with Methyl CpG Binding Protein 2 via Its Intracellular Domain., PMID:35408913
Epigenetic comparison of CHO hosts and clones reveals divergent methylation and transcription patterns across lineages., PMID:35028935
Anti-Semaphorin 4D Rescues Motor, Cognitive, and Respiratory Phenotypes in a Rett Syndrome Mouse Model., PMID:34502373
Long non‑coding RNA expression profiles identify lncRNA‑XLOC_I2_006631 as a potential novel blood biomarker for Hashimoto's thyroiditis., PMID:33125100
Identifying proteins bound to native mitotic ESC chromosomes reveals chromatin repressors are important for compaction., PMID:32807789
Melatonin-induced suppression of DNA methylation promotes odontogenic differentiation in human dental pulp cells., PMID:32718272
Fingolimod Modulates Dendritic Architecture in a BDNF-Dependent Manner., PMID:32349283
Altered inflammasome machinery as a key player in the perpetuation of Rett syndrome oxinflammation., PMID:31606551
Electrochemical determination of the activity of DNA methyltransferase based on the methyl binding domain protein and a customized modular detector., PMID:30848391
Anti-MOG antibody encephalitis mimicking neurological deterioration in a case of Rett syndrome with MECP2 mutation., PMID:30227938
Methyl-CpG-binding protein 2 mediates antifibrotic effects in scleroderma fibroblasts., PMID:29760157
Altered microRNA, mRNA, and Protein Expression of Neurodegeneration-Related Biomarkers and Their Transcriptional and Epigenetic Modifiers in a Human Tau Transgenic Mouse Model in Response to Developmental Lead Exposure., PMID:29614648
Multi-PK antibodies: Powerful analytical tools to explore the protein kinase world., PMID:28955766
Antibiotic Prophylaxis, Immunoglobulin Substitution and Supportive Measures Prevent Infections in MECP2 Duplication Syndrome., PMID:28938254
Identification of autism-related MECP2 mutations by whole-exome sequencing and functional validation., PMID:28785396
Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells., PMID:28754949
Zebrafish Mecp2 is required for proper axonal elongation of motor neurons and synapse formation., PMID:28371371
Promoter CpG-Site Methylation of the KAI1 Metastasis Suppressor Gene Contributes to Its Epigenetic Repression in Prostate Cancer., PMID:27813113
IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics., PMID:27113293
Rett Syndrome Mutant Neural Cells Lacks MeCP2 Immunoreactive Bands., PMID:27064487
Rett syndrome: An autoimmune disease?, PMID:26807990
Methyl-CpG Binding Protein 2 (Mecp2) Regulates Sensory Function Through Sema5b and Robo2., PMID:26733807
Specificity of antinuclear autoantibodies recognizing the dense fine speckled nuclear pattern: Preferential targeting of DFS70/LEDGFp75 over its interacting partner MeCP2., PMID:26235378
MeCP2 in the enteric nervous system., PMID:26031318
Methyl CpG binding protein 2 deficiency enhances expression of inflammatory cytokines by sustaining NF-κB signaling in myeloid derived cells., PMID:26004152
Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms., PMID:25979088
Infectious and immunologic phenotype of MECP2 duplication syndrome., PMID:25721700
Perinatal nicotine exposure suppresses PPARγ epigenetically in lung alveolar interstitial fibroblasts., PMID:25661292
Epigenetic regulation contributes to urocortin-enhanced midbrain dopaminergic neuron differentiation., PMID:25641682
Thyroid function in Rett syndrome., PMID:25614013
Transcriptional Regulation of Brain-Derived Neurotrophic Factor (BDNF) by Methyl CpG Binding Protein 2 (MeCP2): a Novel Mechanism for Re-Myelination and/or Myelin Repair Involved in the Treatment of Multiple Sclerosis (MS)., PMID:25579386
Immune dysfunction in Rett syndrome patients revealed by high levels of serum anti-N(Glc) IgM antibody fraction., PMID:25389532
Isoform-specific anti-MeCP2 antibodies confirm that expression of the e1 isoform strongly predominates in the brain., PMID:24555100
Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum., PMID:24448211
Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndrome., PMID:24352790
Ultrasensitive electrochemical immunoassay for DNA methyltransferase activity and inhibitor screening based on methyl binding domain protein of MeCP2 and enzymatic signal amplification., PMID:23708816
Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse., PMID:23428850
MeCP2 modulates the canonical Wnt pathway activation by targeting SFRP4 in rheumatoid arthritis fibroblast-like synoviocytes in rats., PMID:23200852
Novel MeCP2 isoform-specific antibody reveals the endogenous MeCP2E1 expression in murine brain, primary neurons and astrocytes., PMID:23185431
Association of modified cytosines and the methylated DNA-binding protein MeCP2 with distinctive structural domains of lampbrush chromatin., PMID:23149574
Further evidence of subphenotype association with systemic lupus erythematosus susceptibility loci: a European cases only study., PMID:23049788
For research use only. Not for human or drug use.
