Catalog No.
RHE80601
Species reactivity
Human
Host species
Mouse
Isotype
IgG2b
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, IHC: 1:200-1:1000
Target
GTP-binding protein Ram, Rab-27, Ras-related protein Rab-27A, RAB27, RAB27A
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P51159
Applications
ELISA, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3M45
IL-1β Induces LDL Transcytosis by a Novel Pathway Involving LDLR and Rab27a., PMID:38989581
IL-17A inhibitor-induced leucocytoclastic vasculitis is responsive to IL-23 blockade in a psoriatic arthritis patient., PMID:37679036
External stimulation induces the secretion of autophagosome-like vesicles by B cells., PMID:40395311
Novel Molecular Therapies and Genetic Landscape in Selected Rare Diseases with Hematologic Manifestations: A Review of the Literature., PMID:36766791
Tumour-derived small extracellular vesicles contribute to the tumour progression through reshaping the systemic immune macroenvironment., PMID:36755063
Tumor extracellular vesicles mediate anti-PD-L1 therapy resistance by decoying anti-PD-L1., PMID:36220994
Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses., PMID:36108149
Extracellular vesicles and PD-L1 suppress macrophages, inducing therapy resistance in TP53-deficient B-cell malignancies., PMID:35344582
Neutrophils Require Activation to Express Functional Cell-Surface Complement Receptor Immunoglobulin., PMID:35317169
PDL1-positive exosomes suppress antitumor immunity by inducing tumor-specific CD8+ T cell exhaustion during metastasis., PMID:34152672
The Chromatin Accessibility Landscape of Peripheral Blood Mononuclear Cells in Patients With Systemic Lupus Erythematosus at Single-Cell Resolution., PMID:34084162
Extracellular vesicles-released parathyroid hormone-related protein from Lewis lung carcinoma induces lipolysis and adipose tissue browning in cancer cachexia., PMID:33510128
Intercellular transmission of Seneca Valley virus mediated by exosomes., PMID:32678013
Transfer of extracellular vesicle-microRNA controls germinal center reaction and antibody production., PMID:32073750
Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory., PMID:30951669
Grab recruitment by Rab27A-Rabphilin3a triggers Rab3A activation in human sperm exocytosis., PMID:30599141
Membrane-permeable Rab27A is a regulator of the acrosome reaction: Role of geranylgeranylation and guanine nucleotides., PMID:29337043
Interferon regulatory factor 1-Rab27a regulated extracellular vesicles promote liver ischemia/reperfusion injury., PMID:29059701
Exosomes Mediate Epithelium-Mesenchyme Crosstalk in Organ Development., PMID:28727410
Rab3A, Rab27A, and Rab35 regulate different events during mouse oocyte meiotic maturation and activation., PMID:26791531
Supporting Role for GTPase Rab27a in Hepatitis C Virus RNA Replication through a Novel miR-122-Mediated Effect., PMID:26305877
High Rab27A expression indicates favorable prognosis in CRC., PMID:26070933
Label-free quantitative detection of tumor-derived exosomes through surface plasmon resonance imaging., PMID:25090139
The GTPase Rab37 Participates in the Control of Insulin Exocytosis., PMID:23826383
MADD/DENN/Rab3GEP functions as a guanine nucleotide exchange factor for Rab27 during granule exocytosis of rat parotid acinar cells., PMID:23702376
The interplay between the Rab27A effectors Slp4-a and MyRIP controls hormone-evoked Weibel-Palade body exocytosis., PMID:22898601
Rab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosis., PMID:22753498
Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex., PMID:22308290
EPI64 protein functions as a physiological GTPase-activating protein for Rab27 protein and regulates amylase release in rat parotid acinar cells., PMID:21832089
Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells., PMID:21628593
Actin assembly controlled by GDP-Rab27a is essential for endocytosis of the insulin secretory membrane., PMID:20138020
Neutralization of IFNgamma defeats haemophagocytosis in LCMV-infected perforin- and Rab27a-deficient mice., PMID:20049711
Tumor protein D52 expression and Ca2+-dependent phosphorylation modulates lysosomal membrane protein trafficking to the plasma membrane., PMID:20032513
Rab27a and Rab27b control different steps of the exosome secretion pathway., PMID:19966785
Follicular lymphoma cells induce T-cell immunologic synapse dysfunction that can be repaired with lenalidomide: implications for the tumor microenvironment and immunotherapy., PMID:19786615
Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity., PMID:19704116
Hematopoietic- and neurologic-expressed sequence 1 (Hn1) depletion in B16.F10 melanoma cells promotes a differentiated phenotype that includes increased melanogenesis and cell cycle arrest., PMID:19427096
DNase I inhibits a late phase of reactive oxygen species production in neutrophils., PMID:20375609
Recruitment of Rab27a to phagosomes controls microbial antigen cross-presentation by dendritic cells., PMID:18779337
Analysis of the linkage of MYRIP and MYO7A to melanosomes by RAB27A in retinal pigment epithelial cells., PMID:17352418
Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes., PMID:17351642
NK cytotoxicity mediated by CD16 but not by NKp30 is functional in Griscelli syndrome., PMID:17255357
Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4., PMID:17237785
Functional involvement of Noc2, a Rab27 effector, in rat parotid acinar cells., PMID:17067543
Rab27a negatively regulates CFTR chloride channel function in colonic epithelia: involvement of the effector proteins in the regulatory mechanism., PMID:16762324
Decreased basal mucus secretion by Slp2-a-deficient gastric surface mucous cells., PMID:16716193
Assay of the Rab-binding specificity of rabphilin and Noc2: target molecules for Rab27., PMID:16473612
Analysis of the role of Rab27 effector Slp4-a/Granuphilin-a in dense-core vesicle exocytosis., PMID:16473610
Functional analysis of slac2-a/melanophilin as a linker protein between Rab27A and myosin Va in melanosome transport., PMID:16473608
Identification of proteins differentially expressed in human monocytes exposed to Porphyromonas gingivalis and its purified components by high-throughput immunoblotting., PMID:16428770
For research use only. Not for human or drug use.
