Catalog No.
RHE73903
Species reactivity
Human, Mouse, Rat, Monkey
Host species
Mouse
Isotype
IgG2b
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
HNGS1, Double-strand break repair protein MRE11, MRE11A, Double-strand break repair protein MRE11A, Meiotic recombination 11 homolog A, MRE11 homolog A, MRE11 homolog 1, MRE11, Meiotic recombination 11 homolog 1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P49959
Applications
ELISA, FCM, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3M19
Analysis of MRE11 and Mortality Among Adults With Muscle-Invasive Bladder Cancer Managed With Trimodality Therapy., PMID:36383379
Ex vivo exposures to arsenite and its methylated trivalent metabolites alter gene transcription in mouse sperm cells., PMID:36209798
DNA damage and repair in the visual center in the rhesus monkey model of glaucoma., PMID:35364099
Multiple DSB Resection Activities Redundantly Promote Alternative End Joining-Mediated Class Switch Recombination., PMID:34926456
Topological Analysis of γH2AX and MRE11 Clusters Detected by Localization Microscopy during X-ray-Induced DNA Double-Strand Break Repair., PMID:34771723
MRE11 promotes oral cancer progression through RUNX2/CXCR4/AKT/FOXA2 signaling in a nuclease-independent manner., PMID:33927349
Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment., PMID:32778095
Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly., PMID:32358495
GFI1's role in DNA repair suggests implications for tumour cell response to treatment., PMID:31225488
Identification and characterization of a novel nuclear structure containing members of the homologous recombination and DNA damage response pathways., PMID:30553479
Sensitivity of CD3/CD28-stimulated versus non-stimulated lymphocytes to ionizing radiation and genotoxic anticancer drugs: key role of ATM in the differential radiation response., PMID:30323167
Localization Microscopy Analyses of MRE11 Clusters in 3D-Conserved Cell Nuclei of Different Cell Lines., PMID:29361783
Antibodies against the mono-methylated arginine-glycine repeat (MMA-RG) of the Epstein-Barr virus nuclear antigen 2 (EBNA2) identify potential cellular proteins targeted in viral transformation., PMID:28758620
Studies of the DNA Damage Response by Using the Lac Operator/Repressor (LacO/LacR) Tethering System., PMID:28477125
Telomere Dysfunction Induced Foci (TIF) Analysis., PMID:27500188
Development of a multiparameter flow cytometric assay as a potential biomarker for homologous recombination deficiency in women with high-grade serous ovarian cancer., PMID:26198537
Targeting of the EGFR/β1 integrin connecting proteins PINCH1 and Nck2 radiosensitizes three-dimensional SCC cell cultures., PMID:26004008
Identification of Plasmodium falciparum DNA Repair Protein Mre11 with an Evolutionarily Conserved Nuclease Function., PMID:25938776
Phosphorylation of PTEN at STT motif is associated with DNA damage response., PMID:25771877
Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins., PMID:25605897
Identification of the interactors of human nibrin (NBN) and of its 26 kDa and 70 kDa fragments arising from the NBN 657del5 founder mutation., PMID:25485873
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination., PMID:25404348
The human SRCAP chromatin remodeling complex promotes DNA-end resection., PMID:25176633
Smad7 enhances ATM activity by facilitating the interaction between ATM and Mre11-Rad50-Nbs1 complex in DNA double-strand break repair., PMID:25063542
Ionizing-radiation induced DNA double-strand breaks: a direct and indirect lighting up., PMID:23849169
The MRN-CtIP pathway is required for metaphase chromosome alignment., PMID:23434370
SMC1-mediated intra-S-phase arrest facilitates bocavirus DNA replication., PMID:23365434
Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching., PMID:23254285
Differential activation of cellular DNA damage responses by replication-defective and replication-competent adenovirus mutants., PMID:23015708
Mre11 is expressed in mammalian mitochondria where it binds to mitochondrial DNA., PMID:21677273
Activation of protein kinase Tel1 through recognition of protein-bound DNA ends., PMID:21402778
L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1., PMID:21297581
Autophosphorylation and ATM activation: additional sites add to the complexity., PMID:21149446
Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex., PMID:20943970
Unique DNA repair gene variations and potential associations with the primary antibody deficiency syndromes IgAD and CVID., PMID:20805886
Loss of juxtaposition of RAG-induced immunoglobulin DNA ends is implicated in the precursor B-cell differentiation defect in NBS patients., PMID:20378756
53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair., PMID:20081839
Temporal regulation of Ig gene diversification revealed by single-cell imaging., PMID:19748985
Multiple functions of MRN in end-joining pathways during isotype class switching., PMID:19633670
PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination., PMID:19629035
Meiotic localization of Mre11 and Rad50 in wild type, spo11-1, and MRN complex mutants of Coprinus cinereus., PMID:19396455
Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes., PMID:19180185
A tool for enhancement and scoring of DNA repair foci., PMID:18836995
Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites., PMID:18582474
Cadmium inhibits non-homologous end-joining and over-activates the MRE11-dependent repair pathway., PMID:18539077
Transcriptional profile of the homologous recombination machinery and characterization of the EhRAD51 recombinase in response to DNA damage in Entamoeba histolytica., PMID:18402694
Mechanism and regulation of class switch recombination., PMID:18370922
The Mre11 protein interacts with both Rad50 and the HerA bipolar helicase and is recruited to DNA following gamma irradiation in the archaeon Sulfolobus acidocaldarius., PMID:18294364
Cytological analysis of MRE11 protein during early meiotic prophase I in Arabidopsis and tomato., PMID:18293007
DNA double-strand break repair defects in syndromes associated with acute radiation response: at least two different assays to predict intrinsic radiosensitivity?, PMID:18246480
For research use only. Not for human or drug use.
