Catalog No.
RHE69703
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
IHC: 1:100-1:200
Target
Protein S171, Protein numb homolog, NUMB, C14orf41, h-Numb
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P49757
Applications
IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3L99
Septin 7 interacts with Numb to preserve sarcomere structural organization and muscle contractile function., PMID:38695862
SEPTIN 7 INTERACTS WITH NUMB TO PRESERVE SARCOMERE STRUCTURAL ORGANIZATION AND MUSCLE CONTRACTILE FUNCTION., PMID:37461567
Antiphospholipid Syndrome Secondary to Lupus Anticoagulant: Case Report for Clinical Anticoagulation Determination., PMID:36081977
Aniridia-related keratopathy relevant cell signaling pathways in human fetal corneas., PMID:35551459
Pseudoprogression of lung large cell neuroendocrine carcinoma resembling pancreatic cancer during durvalumab therapy., PMID:34984635
Multiple myeloma with multiple neurological presentations., PMID:31273077
A Single-Cell Immunofluorescence Method for the Division Patterns Research of Mouse Bone Marrow-Derived Hematopoietic Stem Cells., PMID:31062650
Boc Acts via Numb as a Shh-Dependent Endocytic Platform for Ptch1 Internalization and Shh-Mediated Axon Guidance., PMID:31054872
Altered Signaling Pathways in Aniridia-Related Keratopathy., PMID:30480741
Effect of experimentally induced hypothyroidism during gestation period on activity dependent neurotrophic factor (ADNF) in newborn rat brain tissue., PMID:30256757
Numb chin syndrome as a presenting symptom of diffuse large B-cell lymphoma with secondary myelofibrosis., PMID:29930179
Diversity in clinical manifestations and imaging features of neurosyphilis: obstacles to the diagnosis and treatment (report of three cases)., PMID:29199527
Sensitizing effect of juglone is mediated by down regulation of Notch1 signaling pathway in trastuzumab-resistant SKBR3 cells., PMID:27770268
Protein Profile and Morphological Alterations in Penumbra after Focal Photothrombotic Infarction in the Rat Cerebral Cortex., PMID:27324898
Involvement of Numb-mediated HIF-1α inhibition in anti-proliferative effect of PNA-antimiR-182 in trastuzumab-sensitive and -resistant SKBR3 cells., PMID:26563369
Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction., PMID:26523864
Ubiquitin E3 Ligase LNX2 is Critical for Osteoclastogenesis In Vitro by Regulating M-CSF/RANKL Signaling and Notch2., PMID:25712254
[Expression of CD48 as a live marker to distinguish division of hematopoietic stem cells]., PMID:24989257
HMGA1 silencing restores normal stem cell characteristics in colon cancer stem cells by increasing p53 levels., PMID:24833610
Decreased miR-146 expression in peripheral blood mononuclear cells is correlated with ongoing islet autoimmunity in type 1 diabetes patients 1miR-146., PMID:24796653
MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells., PMID:24561623
NOTCH3 signaling regulates MUSASHI-1 expression in metastatic colorectal cancer cells., PMID:24525742
Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs., PMID:24395885
Numb-deficient satellite cells have regeneration and proliferation defects., PMID:24170859
Rbfox3-regulated alternative splicing of Numb promotes neuronal differentiation during development., PMID:23420872
Replication protein a links cell cycle progression and the onset of neurogenesis in Drosophila optic lobe development., PMID:23407946
Drosophila Rbp6 is an orthologue of vertebrate Msi-1 and Msi-2, but does not function redundantly with dMsi to regulate germline stem cell behaviour., PMID:23209605
Dynamic change of Numbl expression after sciatic nerve crush and its role in Schwann cell differentiation., PMID:22437994
The NP9 protein encoded by the human endogenous retrovirus HERV-K(HML-2) negatively regulates gene activation of the Epstein-Barr virus nuclear antigen 2 (EBNA2)., PMID:21710493
Expression of Numb and Numb-like in the development of mammalian auditory sensory epithelium., PMID:21150807
Phosphorylation of the par polarity complex protein Par3 at serine 962 is mediated by aurora a and regulates its function in neuronal polarity., PMID:19812038
Numb protein expression correlates with a basal-like phenotype and cancer stem cell markers in primary breast cancer., PMID:19795205
NIP1/DUOXA1 expression in epithelial breast cancer cells: regulation of cell adhesion and actin dynamics., PMID:19322654
Analysis of partner of inscuteable (mPins) expression in the developing mouse eye., PMID:19122831
Template DNA-strand co-segregation and asymmetric cell division in skeletal muscle stem cells., PMID:19089364
AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis., PMID:18657069
["Numb chin syndrome": first presenting syndrome of multiple sclerosis?]., PMID:18186008
Successful treatment with rituximab in a patient with mental nerve neuropathy in primary Sjögren's syndrome., PMID:17641898
Antiparallel segregation of notch components in the immunological synapse directs reciprocal signaling in allogeneic Th:DC conjugates., PMID:17617572
Novel natural immunogenic peptides from Numb1 and Notch1 proteins for CD8+ cells in ovarian ascites., PMID:17332928
Expression cloning screen for modifiers of amyloid precursor protein shedding., PMID:16446073
Coxsackievirus and adenovirus receptor (CAR) is expressed in male germ cells and forms a complex with the differentiation factor JAM-C in mouse testis., PMID:16410001
Numb cheek syndrome as the first manifestation of anti-Hu paraneoplastic neuronopathy., PMID:16283094
Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs., PMID:16113648
Phosphorylation of Numb family proteins. Possible involvement of Ca2+/calmodulin-dependent protein kinases., PMID:16105844
Asymmetric cell divisions are concentrated in the dermomyotome dorsomedial lip during epaxial primary myotome morphogenesis., PMID:15891908
Drosophila neuroblast 7-3 cell lineage: a model system for studying programmed cell death, Notch/Numb signaling, and sequential specification of ganglion mother cell identity., PMID:15593370
A genetic variant of ACE increases cell survival: a new paradigm for biology and disease., PMID:15110771
Distinct expression patterns of splicing isoforms of mNumb in the endocrine lineage of developing pancreas., PMID:14641329
Fine-tuning Notch1 activation by endocytosis and glycosylation., PMID:12681946
For research use only. Not for human or drug use.
