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Anti-FASN Antibody (R3L87)

Catalog #:   RHE64302 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG1
Applications: IF, IP, WB
Accession: P49327
Overview

Catalog No.

RHE64302

Species reactivity

Human, Mouse, Rat, Monkey

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

IF: 1:50-1:200, IP: 1:20, WB: 1:500-1:1000

Target

Fatty acid synthase, FAS, FASN, Type I fatty acid synthase

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P49327

Applications

IF, IP, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.5% BSA, 0.05% Sodium Azide and 50% Glycerol.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3L87

Data Image
  • Immunofluorescence
    Immunocytochemistry analysis of Fatty Acid Synthase in Hela using Fatty Acid Synthase antibody.
  • Immunoprecipitation
    Immunoprecipitation analysis of Fatty Acid Synthase in CHO-K1 lysates using Fatty Acid Synthase antibody.
  • Western blot
    Western blot analysis of Fatty Acid Synthase in Hela, C6, 3T3, CHO-K1 and MCF-7 lysates using Fatty Acid Synthase antibody.
References

Involvement of microRNAs-449/FASN axis in response to trastuzumab therapy in HER2-positive breast cancer., PMID:40133809

FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma., PMID:38486485

Fatty Acid Synthase Inhibitors Enhance Microtubule-Stabilizing and Microtubule-Destabilizing Drugs in Taxane-Resistant Prostate Cancer Cells., PMID:38093839

Identification of Acetylation Sites of Fatty Acid Synthase (FASN) by Mass Spectrometry and FASN Activity Assay., PMID:37969759

Single-cell transcriptome analysis indicates fatty acid metabolism-mediated metastasis and immunosuppression in male breast cancer., PMID:37696831

Lipid nanoparticle delivery of siRNA targeting Cyp2e1 gene attenuates subacute alcoholic liver injury in mice., PMID:37476942

Bovine muscle satellite cells in calves and cattle: A comparative study of cellular and genetic characteristics for cultivated meat production., PMID:37455679

FBXW7β loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth., PMID:37202390

Phase II Investigation of TVB-2640 (Denifanstat) with Bevacizumab in Patients with First Relapse High-Grade Astrocytoma., PMID:37093199

IGFBP-3 promotes cachexia-associated lipid loss by suppressing insulin-like growth factor/insulin signaling., PMID:37014770

Fatty acid synthase as a new therapeutic target for HER2-positive gastric cancer., PMID:36753044

Modulation of Breast Cancer Cell FASN Expression by Obesity-Related Systemic Factors., PMID:36035625

Therapeutic efficacy of FASN inhibition in preclinical models of HCC., PMID:35076948

Fatty acid synthase mediates high glucose-induced EGFR activation in oral dysplastic keratinocytes., PMID:34402100

Clozapine Worsens Glucose Intolerance, Nonalcoholic Fatty Liver Disease, Kidney Damage, and Retinal Injury and Increases Renal Reactive Oxygen Species Production and Chromium Loss in Obese Mice., PMID:34206460

Cannabinoid Receptor 1 associates to different molecular complexes during GABAergic neuron maturation., PMID:33942314

Cytotoxicity and Radiosensitizing Activity of the Fatty Acid Synthase Inhibitor C75 Is Enhanced by Blocking Fatty Acid Uptake in Prostate Cancer Cells., PMID:33083663

Fatty Acid Synthase (FASN) siRNA-Encapsulated-Her-2 Targeted Fab'-Immunoliposomes for Gene Silencing in Breast Cancer Cells., PMID:32801705

Reprogramming of lipid metabolism in cancer-associated fibroblasts potentiates migration of colorectal cancer cells., PMID:32327627

The IKKβ-USP30-ACLY Axis Controls Lipogenesis and Tumorigenesis., PMID:32221968

SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase., PMID:31677030

Effect of selenium nanoparticles against abnormal fatty acid metabolism induced by hexavalent chromium in chicken's liver., PMID:31134545

Novel treatment strategies for patients with HER2-positive breast cancer who do not benefit from current targeted therapy drugs., PMID:30186457

Biologic Response of Colorectal Cancer Xenograft Tumors to Sequential Treatment with Panitumumab and Bevacizumab., PMID:29802988

TCA cycle rewiring fosters metabolic adaptation to oxygen restriction in skeletal muscle from rodents and humans., PMID:28852047

[Influence of hepatitis B virus X gene on apoptosis of hepatic cells mediated by Fas]., PMID:28763859

Fatty acid synthase reprograms the epigenome in uterine leiomyosarcomas., PMID:28654693

Fatty Acid Synthase and Acetyl-CoA Carboxylase Are Expressed in Nodal Metastatic Melanoma But Not in Benign Intracapsular Nodal Nevi., PMID:28654463

Tanshinone IIA Attenuates Atherosclerosis in Apolipoprotein E Knockout Mice Infected with Porphyromonas gingivalis., PMID:28646427

PROTECTIVE EFFECT OF CAMEL MILK AS ANTI-DIABETIC SUPPLEMENT: BIOCHEMICAL, MOLECULAR AND IMMUNOHISTOCHEMICAL STUDY., PMID:28638873

Combination Treatment with Orlistat-Containing Nanoparticles and Taxanes Is Synergistic and Enhances Microtubule Stability in Taxane-Resistant Prostate Cancer Cells., PMID:28615298

[Fatty acid synthase in the diagnosis of prostate neoplasms]., PMID:28418352

Inhibition of Fatty Acid Synthase Reduces Blastocyst Hatching through Regulation of the AKT Pathway in Pigs., PMID:28107461

Palmitate-induced ER stress increases trastuzumab sensitivity in HER2/neu-positive breast cancer cells., PMID:27464732

Preclinical Evaluation of Fatty Acid Synthase and EGFR Inhibition in Triple-Negative Breast Cancer., PMID:27106068

Docosahexaenoic Acid Modulates a HER2-Associated Lipogenic Phenotype, Induces Apoptosis, and Increases Trastuzumab Action in HER2-Overexpressing Breast Carcinoma Cells., PMID:26640797

Molecular profiling of cetuximab and bevacizumab treatment of colorectal tumours reveals perturbations in metabolic and hypoxic response pathways., PMID:26517691

CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARα pathways., PMID:26282231

Co-regulation of SREBP-1 and mTOR ameliorates lipid accumulation in kidney of diabetic mice., PMID:26112216

Dual fatty acid synthase and HER2 signaling blockade shows marked antitumor activity against breast cancer models resistant to anti-HER2 drugs., PMID:26107737

Activated α2-macroglobulin binding to human prostate cancer cells triggers insulin-like responses., PMID:25720493

Creating leptin-like biofunctions by active immunization against chicken leptin receptor in growing chickens., PMID:25447880

Novel nuclear localization of fatty acid synthase correlates with prostate cancer aggressiveness., PMID:24907642

The mTOR inhibitor rapamycin synergizes with a fatty acid synthase inhibitor to induce cytotoxicity in ER/HER2-positive breast cancer cells., PMID:24866893

Prognostic impact of fatty acid synthase expression in upper urinary tract urothelial carcinoma., PMID:24643292

Antithymocyte globulin is associated with a lower incidence of de novo donor-specific antibodies in moderately sensitized renal transplant recipients., PMID:24531846

Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer., PMID:24510238

The Kaposi's sarcoma-associated herpesvirus (KSHV)-induced 5-lipoxygenase-leukotriene B4 cascade plays key roles in KSHV latency, monocyte recruitment, and lipogenesis., PMID:24335295

Elevated fatty acid synthase expression in prostate needle biopsy cores predicts upgraded Gleason score in radical prostatectomy specimens., PMID:24108439

Impact of hematopoietic cyclooxygenase-1 deficiency on obesity-linked adipose tissue inflammation and metabolic disorders in mice., PMID:23987235

Datasheet

Document Download

Anti-FASN Antibody (R3L87).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

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Anti-FASN Antibody (R3L87) [RHE64302]
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