Catalog No.
RHE64302
Species reactivity
Human, Mouse, Rat, Monkey
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IP: 1:20, WB: 1:500-1:1000
Target
Fatty acid synthase, FAS, FASN, Type I fatty acid synthase
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P49327
Applications
IF, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.5% BSA, 0.05% Sodium Azide and 50% Glycerol.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3L87
Involvement of microRNAs-449/FASN axis in response to trastuzumab therapy in HER2-positive breast cancer., PMID:40133809
FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma., PMID:38486485
Fatty Acid Synthase Inhibitors Enhance Microtubule-Stabilizing and Microtubule-Destabilizing Drugs in Taxane-Resistant Prostate Cancer Cells., PMID:38093839
Identification of Acetylation Sites of Fatty Acid Synthase (FASN) by Mass Spectrometry and FASN Activity Assay., PMID:37969759
Single-cell transcriptome analysis indicates fatty acid metabolism-mediated metastasis and immunosuppression in male breast cancer., PMID:37696831
Lipid nanoparticle delivery of siRNA targeting Cyp2e1 gene attenuates subacute alcoholic liver injury in mice., PMID:37476942
Bovine muscle satellite cells in calves and cattle: A comparative study of cellular and genetic characteristics for cultivated meat production., PMID:37455679
FBXW7β loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth., PMID:37202390
Phase II Investigation of TVB-2640 (Denifanstat) with Bevacizumab in Patients with First Relapse High-Grade Astrocytoma., PMID:37093199
IGFBP-3 promotes cachexia-associated lipid loss by suppressing insulin-like growth factor/insulin signaling., PMID:37014770
Fatty acid synthase as a new therapeutic target for HER2-positive gastric cancer., PMID:36753044
Modulation of Breast Cancer Cell FASN Expression by Obesity-Related Systemic Factors., PMID:36035625
Therapeutic efficacy of FASN inhibition in preclinical models of HCC., PMID:35076948
Fatty acid synthase mediates high glucose-induced EGFR activation in oral dysplastic keratinocytes., PMID:34402100
Clozapine Worsens Glucose Intolerance, Nonalcoholic Fatty Liver Disease, Kidney Damage, and Retinal Injury and Increases Renal Reactive Oxygen Species Production and Chromium Loss in Obese Mice., PMID:34206460
Cannabinoid Receptor 1 associates to different molecular complexes during GABAergic neuron maturation., PMID:33942314
Cytotoxicity and Radiosensitizing Activity of the Fatty Acid Synthase Inhibitor C75 Is Enhanced by Blocking Fatty Acid Uptake in Prostate Cancer Cells., PMID:33083663
Fatty Acid Synthase (FASN) siRNA-Encapsulated-Her-2 Targeted Fab'-Immunoliposomes for Gene Silencing in Breast Cancer Cells., PMID:32801705
Reprogramming of lipid metabolism in cancer-associated fibroblasts potentiates migration of colorectal cancer cells., PMID:32327627
The IKKβ-USP30-ACLY Axis Controls Lipogenesis and Tumorigenesis., PMID:32221968
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase., PMID:31677030
Effect of selenium nanoparticles against abnormal fatty acid metabolism induced by hexavalent chromium in chicken's liver., PMID:31134545
Novel treatment strategies for patients with HER2-positive breast cancer who do not benefit from current targeted therapy drugs., PMID:30186457
Biologic Response of Colorectal Cancer Xenograft Tumors to Sequential Treatment with Panitumumab and Bevacizumab., PMID:29802988
TCA cycle rewiring fosters metabolic adaptation to oxygen restriction in skeletal muscle from rodents and humans., PMID:28852047
[Influence of hepatitis B virus X gene on apoptosis of hepatic cells mediated by Fas]., PMID:28763859
Fatty acid synthase reprograms the epigenome in uterine leiomyosarcomas., PMID:28654693
Fatty Acid Synthase and Acetyl-CoA Carboxylase Are Expressed in Nodal Metastatic Melanoma But Not in Benign Intracapsular Nodal Nevi., PMID:28654463
Tanshinone IIA Attenuates Atherosclerosis in Apolipoprotein E Knockout Mice Infected with Porphyromonas gingivalis., PMID:28646427
PROTECTIVE EFFECT OF CAMEL MILK AS ANTI-DIABETIC SUPPLEMENT: BIOCHEMICAL, MOLECULAR AND IMMUNOHISTOCHEMICAL STUDY., PMID:28638873
Combination Treatment with Orlistat-Containing Nanoparticles and Taxanes Is Synergistic and Enhances Microtubule Stability in Taxane-Resistant Prostate Cancer Cells., PMID:28615298
[Fatty acid synthase in the diagnosis of prostate neoplasms]., PMID:28418352
Inhibition of Fatty Acid Synthase Reduces Blastocyst Hatching through Regulation of the AKT Pathway in Pigs., PMID:28107461
Palmitate-induced ER stress increases trastuzumab sensitivity in HER2/neu-positive breast cancer cells., PMID:27464732
Preclinical Evaluation of Fatty Acid Synthase and EGFR Inhibition in Triple-Negative Breast Cancer., PMID:27106068
Docosahexaenoic Acid Modulates a HER2-Associated Lipogenic Phenotype, Induces Apoptosis, and Increases Trastuzumab Action in HER2-Overexpressing Breast Carcinoma Cells., PMID:26640797
Molecular profiling of cetuximab and bevacizumab treatment of colorectal tumours reveals perturbations in metabolic and hypoxic response pathways., PMID:26517691
CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARα pathways., PMID:26282231
Co-regulation of SREBP-1 and mTOR ameliorates lipid accumulation in kidney of diabetic mice., PMID:26112216
Dual fatty acid synthase and HER2 signaling blockade shows marked antitumor activity against breast cancer models resistant to anti-HER2 drugs., PMID:26107737
Activated α2-macroglobulin binding to human prostate cancer cells triggers insulin-like responses., PMID:25720493
Creating leptin-like biofunctions by active immunization against chicken leptin receptor in growing chickens., PMID:25447880
Novel nuclear localization of fatty acid synthase correlates with prostate cancer aggressiveness., PMID:24907642
The mTOR inhibitor rapamycin synergizes with a fatty acid synthase inhibitor to induce cytotoxicity in ER/HER2-positive breast cancer cells., PMID:24866893
Prognostic impact of fatty acid synthase expression in upper urinary tract urothelial carcinoma., PMID:24643292
Antithymocyte globulin is associated with a lower incidence of de novo donor-specific antibodies in moderately sensitized renal transplant recipients., PMID:24531846
Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer., PMID:24510238
The Kaposi's sarcoma-associated herpesvirus (KSHV)-induced 5-lipoxygenase-leukotriene B4 cascade plays key roles in KSHV latency, monocyte recruitment, and lipogenesis., PMID:24335295
Elevated fatty acid synthase expression in prostate needle biopsy cores predicts upgraded Gleason score in radical prostatectomy specimens., PMID:24108439
Impact of hematopoietic cyclooxygenase-1 deficiency on obesity-linked adipose tissue inflammation and metabolic disorders in mice., PMID:23987235
For research use only. Not for human or drug use.
