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Anti-TDO2 Antibody (R3L79)

Catalog #:   RHE61701 Specific References (13) DATASHEET
Host species: Mouse
Isotype: IgG2a
Applications: IHC
Accession: P48775
Overview

Catalog No.

RHE61701

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a

Clonality

Monoclonal

Tested applications

IHC: 1:50-1:200

Target

TRPO, Tryptophan pyrrolase, Tryptophan oxygenase, TDO2, TDO, TO, Tryptophanase, Tryptophan 2,3-dioxygenase, Tryptamin 2,3-dioxygenase

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P48775

Applications

IHC

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3L79

Data Image
  • Immunohistochemical
    IHC-P analysis of liver tissue by TDO2 antibody (RHE61701). IHC-P was performed using sections of the formalin-fixed paraffin-embedded liver tissue;Result: Hepatocytes are positively stained at the cytoplasm.
References

Activated kynurenine pathway metabolism by YKL-40 establishes an inhibitory immune microenvironment and drives glioblastoma development., PMID:39718635

Dual inhibition of IDO1/TDO2 enhances anti-tumor immunity in platinum-resistant non-small cell lung cancer., PMID:37226257

PDPN positive CAFs contribute to HER2 positive breast cancer resistance to trastuzumab by inhibiting antibody-dependent NK cell-mediated cytotoxicity., PMID:36812747

The Correlation of Ten Immune Checkpoint Gene Expressions and Their Association with Gastric Cancer Development., PMID:36430322

TDO2+ myofibroblasts mediate immune suppression in malignant transformation of squamous cell carcinoma., PMID:35972800

Sodium Tanshinone IIA Sulfonate as a Potent IDO1/TDO2 Dual Inhibitor Enhances Anti-PD1 Therapy for Colorectal Cancer in Mice., PMID:35571116

Alterations in Kynurenine and NAD+ Salvage Pathways during the Successful Treatment of Inflammatory Bowel Disease Suggest HCAR3 and NNMT as Potential Drug Targets., PMID:34948292

Autoantibody profiles associated with clinical features in psychotic disorders., PMID:34518517

TDO2 overexpression correlates with poor prognosis, cancer stemness, and resistance to cetuximab in bladder cancer., PMID:34101386

Expression of the IDO1/TDO2-AhR pathway in tumor cells or the tumor microenvironment is associated with Merkel cell polyomavirus status and prognosis in Merkel cell carcinoma., PMID:30240768

Inhibiting IDO pathways to treat cancer: lessons from the ECHO-301 trial and beyond., PMID:30203227

Accumulation of an endogenous tryptophan-derived metabolite in colorectal and breast cancers., PMID:25881064

Point mutations within 663-666 bp of intron 6 of the human TDO2 gene, associated with a number of psychiatric disorders, damage the YY-1 transcription factor binding site., PMID:10580097

Datasheet

Document Download

Anti-TDO2 Antibody (R3L79).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

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Anti-TDO2 Antibody (R3L79) [RHE61701]
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