Catalog No.
RHE61701
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
IHC: 1:50-1:200
Target
TRPO, Tryptophan pyrrolase, Tryptophan oxygenase, TDO2, TDO, TO, Tryptophanase, Tryptophan 2,3-dioxygenase, Tryptamin 2,3-dioxygenase
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P48775
Applications
IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3L79
Activated kynurenine pathway metabolism by YKL-40 establishes an inhibitory immune microenvironment and drives glioblastoma development., PMID:39718635
Dual inhibition of IDO1/TDO2 enhances anti-tumor immunity in platinum-resistant non-small cell lung cancer., PMID:37226257
PDPN positive CAFs contribute to HER2 positive breast cancer resistance to trastuzumab by inhibiting antibody-dependent NK cell-mediated cytotoxicity., PMID:36812747
The Correlation of Ten Immune Checkpoint Gene Expressions and Their Association with Gastric Cancer Development., PMID:36430322
TDO2+ myofibroblasts mediate immune suppression in malignant transformation of squamous cell carcinoma., PMID:35972800
Sodium Tanshinone IIA Sulfonate as a Potent IDO1/TDO2 Dual Inhibitor Enhances Anti-PD1 Therapy for Colorectal Cancer in Mice., PMID:35571116
Alterations in Kynurenine and NAD+ Salvage Pathways during the Successful Treatment of Inflammatory Bowel Disease Suggest HCAR3 and NNMT as Potential Drug Targets., PMID:34948292
Autoantibody profiles associated with clinical features in psychotic disorders., PMID:34518517
TDO2 overexpression correlates with poor prognosis, cancer stemness, and resistance to cetuximab in bladder cancer., PMID:34101386
Expression of the IDO1/TDO2-AhR pathway in tumor cells or the tumor microenvironment is associated with Merkel cell polyomavirus status and prognosis in Merkel cell carcinoma., PMID:30240768
Inhibiting IDO pathways to treat cancer: lessons from the ECHO-301 trial and beyond., PMID:30203227
Accumulation of an endogenous tryptophan-derived metabolite in colorectal and breast cancers., PMID:25881064
Point mutations within 663-666 bp of intron 6 of the human TDO2 gene, associated with a number of psychiatric disorders, damage the YY-1 transcription factor binding site., PMID:10580097
For research use only. Not for human or drug use.
