Catalog No.
RHE47601
Species reactivity
Human
Host species
Mouse
Isotype
IgG2b
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000, IHC: 1:200-1:1000
Target
Adapter molecule crk, p38, CRK, Proto-oncogene c-Crk
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P46108
Applications
ELISA, FCM, IF, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3L53
Tetanus and Diphtheria Toxoid-Containing Vaccine in Multiple Sclerosis Patients: A Real-World Prospective, Open-Label, Multi-Centre Study., PMID:40432063
Genome-Wide Investigation of CPK-Related Kinase (CRK) Gene Family in Arabidopsis thaliana., PMID:40244143
Efficacy of Ofatumumab and Teriflunomide in Patients With Relapsing MS From Racial/Ethnic Minority Groups: ASCLEPIOS I/II Subgroup Analyses., PMID:39018512
Efficacy, Safety, and Cost-effectiveness of Bezlotoxumab in Preventing Recurrent Clostridioides difficile Infection : Systematic Review and Meta-analysis., PMID:37395627
Preservation of Proteins in Human Plasma through Metal-Organic Framework Encapsulation., PMID:37015072
A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum., PMID:35344575
Global Seroprevalence of Pre-existing Immunity Against AAV5 and Other AAV Serotypes in People with Hemophilia A., PMID:35156839
Endothelial p130cas confers resistance to anti-angiogenesis therapy., PMID:35081345
Mechanism of disease and therapeutic rescue of Dok7 congenital myasthenia., PMID:34163073
Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum., PMID:33594061
Downregulated miR‑29a promotes B cell overactivation by upregulating Crk‑like protein in systemic lupus erythematosus., PMID:32467986
Characterization of two in vivo challenge models to measure functional activity of monoclonal antibodies to Plasmodium falciparum circumsporozoite protein., PMID:32183833
Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein., PMID:32150583
Modeling ErbB2-p130Cas interaction to design new potential anticancer agents., PMID:30816273
Carboxy-terminal domain of Cas differentially modulates c-Jun expression, DNA synthesis, and membrane ruffling induced by insulin, EGF, and IGF-1., PMID:30460082
Development and characterization of a novel monoclonal antibody that recognizes an epitope in the central protein interaction domain of RapGEF1 (C3G)., PMID:30143974
Murine chronic graft-versus-host disease proteome profiling discovers CCL15 as a novel biomarker in patients., PMID:29348127
NLRC4 inflammasomopathies., PMID:28957823
Crk adaptor proteins regulate CD3ζ chain phosphorylation and TCR/CD3 down-modulation in activated T cells., PMID:28465009
Vitamin C Modulates the Immunotoxic Effect of 17α-Methyltestosterone in Nile Tilapia., PMID:28322549
ESCRT-I Protein Tsg101 Plays a Role in the Post-macropinocytic Trafficking and Infection of Endothelial Cells by Kaposi's Sarcoma-Associated Herpesvirus., PMID:27764233
Fecal Gluten Peptides Reveal Limitations of Serological Tests and Food Questionnaires for Monitoring Gluten-Free Diet in Celiac Disease Patients., PMID:27644734
Suppression of IL-8-Src signalling axis by 17β-estradiol inhibits human mesenchymal stem cells-mediated gastric cancer invasion., PMID:26945908
Reduction of CRKL expression in patients with partial DiGeorge syndrome is associated with impairment of T-cell functions., PMID:26875746
p130Cas scaffold protein regulates ErbB2 stability by altering breast cancer cell sensitivity to autophagy., PMID:26716506
The IL-15-Based ALT-803 Complex Enhances FcγRIIIa-Triggered NK Cell Responses and In Vivo Clearance of B Cell Lymphomas., PMID:26423796
A Kinase-Independent Function of c-Src Mediates p130Cas Phosphorylation at the Serine-639 Site in Pressure Overloaded Myocardium., PMID:25976166
Nck adaptors, besides promoting N-WASP mediated actin-nucleation activity at pedestals, influence the cellular levels of enteropathogenic Escherichia coli Tir effector., PMID:25482634
Iterative tyrosine phosphorylation controls non-canonical domain utilization in Crk., PMID:25381819
17β-Estradiol inhibition of IL-6-Src and Cas and paxillin pathway suppresses human mesenchymal stem cells-mediated gastric cancer cell motility., PMID:24801617
The Chlamydia trachomatis type III secretion chaperone Slc1 engages multiple early effectors, including TepP, a tyrosine-phosphorylated protein required for the recruitment of CrkI-II to nascent inclusions and innate immune signaling., PMID:24586162
A monoclonal antibody targeting neuropilin-1 inhibits adhesion of MCF7 breast cancer cells to fibronectin by suppressing the FAK/p130cas signaling pathway., PMID:24583771
IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice., PMID:24492468
FoxO1 is a negative regulator of FSHβ gene expression in basal and GnRH-stimulated conditions in female., PMID:24437485
17β-estradiol inhibits mesenchymal stem cells-induced human AGS gastric cancer cell mobility via suppression of CCL5- Src/Cas/Paxillin signaling pathway., PMID:24396281
SRChing for the substrates of Src., PMID:24121272
Tyrosine phosphorylation of the orphan receptor ESDN/DCBLD2 serves as a scaffold for the signaling adaptor CrkL., PMID:23770091
Src-inducible association of CrkL with procaspase-8 promotes cell migration., PMID:23751956
Ductal carcinoma of the prostate shows a different immunophenotype from high grade acinar cancer., PMID:23701402
DNA prime/Adenovirus boost malaria vaccine encoding P. falciparum CSP and AMA1 induces sterile protection associated with cell-mediated immunity., PMID:23457473
Dock mediates Scar- and WASp-dependent actin polymerization through interaction with cell adhesion molecules in founder cells and fusion-competent myoblasts., PMID:22992459
Impaired c-src activation and motility defects in PEA3-null fibroblasts., PMID:22982417
Integrin-mediated mechanotransduction pathway of low-intensity continuous ultrasound in human chondrocytes., PMID:22920546
Identification of targets of c-Src tyrosine kinase by chemical complementation and phosphoproteomics., PMID:22499769
The adaptor protein Crk controls activation and inhibition of natural killer cells., PMID:22464172
Protein pathway activation mapping reveals molecular networks associated with antiestrogen resistance in breast cancer cell lines., PMID:22328489
BCAR1 expression improves prediction of biochemical reccurence after radical prostatectomy., PMID:22241677
Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP component., PMID:22003411
Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adults., PMID:22003383
Silencing of p130cas in ovarian carcinoma: a novel mechanism for tumor cell death., PMID:21957230
For research use only. Not for human or drug use.
