Catalog No.
RHE42902
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
Tyrosine-protein kinase ZAP-70, ZAP70, Syk-related tyrosine kinase, 70 kDa zeta-chain associated protein, SRK
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P43403
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3L15
The immunosuppressive effect of glucocorticoids in human primary T cells is mainly mediated via a rapid inhibition of the IL-2/IL-2R signaling axis., PMID:40468327
PILRα on tumor cells interacts with the T cell surface protein CD99 to suppress antitumor immunity., PMID:40312493
CD28 shapes T cell receptor signaling by regulating Lck dynamics and ZAP70 activation., PMID:39776902
Immunoglobulin M-based local production in skin-associated lymphoid tissue of flounder (Paralichthys olivaceus) initiated by immersion with inactivated Edwardsiella tarda., PMID:39461396
Deuterated water labeling in ibrutinib-treated patients with CLL: leukemia cell kinetics correlate with IGHV, ZAP-70, and MRD., PMID:39441901
PTPN22 through the regulation of Th17/Treg balance acts as a potential target for the treatment of Graves' disease., PMID:39083881
CD147 regulates the formation and function of immune synapses., PMID:38909549
Clinical features and lymphocyte immunophenotyping analysis in primary immunodeficiency patients with non-transplant lymphoproliferative disorders., PMID:38838929
HIV/HBV coinfection remodels the immune landscape and natural killer cell ADCC functional responses., PMID:38687604
FcαRI (CD89) is upregulated on subsets of mucosal and circulating NK cells and regulates IgA-class specific signaling and functions., PMID:38677592
Tetracyclines enhance antitumor T-cell immunity via the Zap70 signaling pathway., PMID:38621815
ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion., PMID:38614099
Normal B cells express ZAP70 in chronic lymphocytic leukemia: A link between autoimmunity and lymphoproliferation?, PMID:37853951
Evaluation of Diagnostic Usefulness of CD200 Expression in B-cell Chronic Lymphoproliferative Disorders., PMID:37786819
Single-cell RNA sequencing identifies distinct transcriptomic signatures between PMA/ionomycin- and αCD3/αCD28-activated primary human T cells., PMID:37704208
INPP5E regulates CD3ζ enrichment at the immune synapse by phosphoinositide distribution control., PMID:37670137
Pathogenicity of IgG-Fc desialylation and its association with Th17 cells in an animal model of systemic lupus erythematosus., PMID:37300805
Clinical Features and Genetic Analysis of Taiwanese Primary Immunodeficiency Patients with Prolonged Diarrhea and Monogenetic Inflammatory Bowel Disease., PMID:37202577
A Non-Canonical Role for the Glycosyltransferase Enzyme UGT2B17 as a Novel Constituent of the B Cell Receptor Signalosome., PMID:37174695
Ablation of SYK Kinase from Expanded Primary Human NK Cells via CRISPR/Cas9 Enhances Cytotoxicity and Cytokine Production., PMID:36881874
Using the Jurkat reporter T cell line for evaluating the functionality of novel chimeric antigen receptors., PMID:39086686
Enteric Toll-like receptor 7 stimulation causes acute exacerbation in lupus-susceptible mice., PMID:36515794
Spatial requirements for ITAM signaling in an intracellular natural killer cell model membrane., PMID:35933027
Modeling the B-cell receptor signaling on single cell level reveals a stable network circuit topology between nonmalignant B cells and chronic lymphocytic leukemia cells and between untreated cells and cells treated with kinase inhibitors., PMID:35527719
SYK and ZAP70 kinases in autoimmunity and lymphoid malignancies., PMID:35398488
Fluid shear stress enhances T cell activation through Piezo1., PMID:35260156
Protein-PAINT: Superresolution microscopy with signaling proteins., PMID:35104163
High-Resolution, 3D Imaging of the Zebrafish Gill-Associated Lymphoid Tissue (GIALT) Reveals a Novel Lymphoid Structure, the Amphibranchial Lymphoid Tissue., PMID:34880866
Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease., PMID:34814699
Differential diagnosis of primary immunodeficiency in patients with BCGitis and BCGosis: A single-centre study., PMID:34780073
RPPA-based proteomics recognizes distinct epigenetic signatures in chronic lymphocytic leukemia with clinical consequences., PMID:34625713
Lymphoid blast transformation in an MPN with BCR-JAK2 treated with ruxolitinib: putative mechanisms of resistance., PMID:34505882
Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies., PMID:34326166
Expression of BCL6 in paediatric B-cell acute lymphoblastic leukaemia and association with prognosis., PMID:34049715
Cbl-b deficiency prevents functional but not phenotypic T cell anergy., PMID:33974042
Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer., PMID:33878293
An IgD-Fc-Ig fusion protein restrains the activation of T and B cells by inhibiting IgD-IgDR-Lck signaling in rheumatoid arthritis., PMID:33864023
Myeloid-derived suppressor cell (MDSC) key genes analysis in rat anti-CD28-induced immune tolerance kidney transplantation., PMID:33532310
A novel zeta-associated protein 70 homozygous mutation causing combined immunodeficiency presenting as neonatal autoimmune hemolytic anemia., PMID:33484432
Analysis of protein denaturation, aggregation and post-translational modification by agarose native gel electrophoresis., PMID:33454336
Galectin-9 expression defines exhausted T cells and impaired cytotoxic NK cells in patients with virus-associated solid tumors., PMID:33310773
Transcriptome analysis reveals potential immune function-related regulatory genes/pathways of female Lubo goat submandibular glands at different developmental stages., PMID:33083113
CD103 Promotes the Pro-inflammatory Response of Gastric Resident CD4+ T Cell in Helicobacter pylori-Positive Gastritis., PMID:32974219
High M-MDSC Percentage as a Negative Prognostic Factor in Chronic Lymphocytic Leukaemia., PMID:32937740
Targeting Phosphotyrosine in Native Proteins with Conditional, Bispecific Antibody Traps., PMID:32924468
LPL deletion is associated with poorer response to ibrutinib-based treatments and overall survival in TP53-deleted chronic lymphocytic leukemia., PMID:32833105
Mechanisms determining a differential threshold for sensing Src family kinase activity by B and T cell antigen receptors., PMID:32665402
Regulation of T Cell Activities in Rheumatoid Arthritis by the Novel Fusion Protein IgD-Fc-Ig., PMID:32499775
Unsupervised machine learning and prognostic factors of survival in chronic lymphocytic leukemia., PMID:32483590
For research use only. Not for human or drug use.
