Catalog No.
RHE34503
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:50, IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
STAT5A, STAT5, Signal transducer and activator of transcription 5A
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P42229
Applications
ELISA, FCM, IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3K70
Oleic acid regulates CD4+ T cells differentiation by targeting ODC1-mediated STAT5A phosphorylation in Vogt-Koyanagi-Harada disease., PMID:40203473
Inhibition of Kinase Activity and In Vitro Downregulation of the Protein Kinases in Lung Cancer and Cervical Cancer Cell Lines and the Identified Known Anticancer Compounds of Ziziphus mucronata., PMID:39942957
IQGAP1 promotes early B cell development, is essential for the development of marginal zone (MZ) B cells, and is critical for both T-dependent and T-independent antibody responses., PMID:39585462
STAT4 and STAT6, their role in cellular and humoral immunity and in diverse human diseases., PMID:39188021
JAK/STAT signaling in rheumatoid arthritis leukocytes is uncoupled from serum cytokines in a subset of patients., PMID:38729230
Single-cell insights: pioneering an integrated atlas of chromatin accessibility and transcriptomic landscapes in diabetic cardiomyopathy., PMID:38664790
LFA-1 regulated by IL-2/STAT5 pathway boosts antitumor function of intratumoral CD8+ T cells for improving anti-PD-1 antibody therapy., PMID:38125721
Overexpression and potential roles of midkine via regulation of vascular endothelial growth factor A in psoriasis., PMID:37218430
Identification and phenotypic characterization of patients with LADA in a population of southeast Mexico., PMID:37120620
IgG:FcγRIIb signals block effector programs of IgE:FcεRI-activated mast cells but spare survival pathways., PMID:37030590
A bibliometric review of peripartum cardiomyopathy compared to other cardiomyopathies using artificial intelligence and machine learning., PMID:35340600
Blocking GM-CSF receptor α with mavrilimumab reduces infiltrating cells, pro-inflammatory markers and neoangiogenesis in ex vivo cultured arteries from patients with giant cell arteritis., PMID:35045965
Centromere protein F promotes progression of hepatocellular carcinoma through ERK and cell cycle-associated pathways., PMID:34857915
A STAT5B-CD9 axis determines self-renewal in hematopoietic and leukemic stem cells., PMID:34320169
Erythropoietin Reduces Auto- and Alloantibodies by Inhibiting T Follicular Helper Cell Differentiation., PMID:34261755
GM-CSF mediates immune evasion via upregulation of PD-L1 expression in extranodal natural killer/T cell lymphoma., PMID:34051805
Decreased Treg Cell and TCR Expansion Are Involved in Long-Lasting Graves' Disease., PMID:33912135
IL-10 derived from Hepatocarcinoma cells improves human induced regulatory T cells function via JAK1/STAT5 pathway in tumor microenvironment., PMID:33667986
Early stability and late random tumor progression of a HER2-positive primary breast cancer patient-derived xenograft., PMID:33452364
IL-2 contributes to cirrhosis-associated immune dysfunction by impairing follicular T helper cells in advanced cirrhosis., PMID:33211012
Effect of CIP2A and its mechanism of action in the malignant biological behavior of colorectal cancer., PMID:32321509
Estrogen Receptor, Inflammatory, and FOXO Transcription Factors Regulate Expression of Myasthenia Gravis-Associated Circulating microRNAs., PMID:32153563
IL-7-Mediated IL-7R-JAK3/STAT5 signalling pathway contributes to chemotherapeutic sensitivity in non-small-cell lung cancer., PMID:31599032
Low UBE4B expression increases sensitivity of chemoresistant neuroblastoma cells to EGFR and STAT5 inhibition., PMID:31475882
Upregulation of SLAMF3 on human T cells is induced by palmitic acid through the STAT5-PI3K/Akt pathway and features the chronic inflammatory profiles of type 2 diabetes., PMID:31332162
Mechano-growth Factor Expression in Colorectal Cancer Investigated With Fluorescent Gold Nanoparticles., PMID:30952709
Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn's Disease., PMID:30124884
Myeloid-Derived Suppressor Cells Impair B Cell Responses in Lung Cancer through IL-7 and STAT5., PMID:29752311
FoxP3+ regulatory T cells, interleukin 17 and mast cells in chronic inflammatory periodontal disease., PMID:29633265
Progenitor B-1 B-cell acute lymphoblastic leukemia is associated with collaborative mutations in 3 critical pathways., PMID:29296821
Local blockage of self-sustainable erythropoietin signaling suppresses tumor progression in non-small cell lung cancer., PMID:29137269
Prolactin receptor targeting in breast and prostate cancers: New insights into an old challenge., PMID:28549597
STAT5A-mediated NOX5-L expression promotes the proliferation and metastasis of breast cancer cells., PMID:28034671
mTOR inhibition potentiates cytotoxicity of Vγ4 γδ T cells via up-regulating NKG2D and TNF-α., PMID:27256566
Direct coupling of the HER4 intracellular domain (4ICD) and STAT5A signaling is required to induce mammary epithelial cell differentiation., PMID:28955922
Validation of tumor protein marker quantification by two independent automated immunofluorescence image analysis platforms., PMID:27312066
STAT3/5-Dependent IL9 Overexpression Contributes to Neoplastic Cell Survival in Mycosis Fungoides., PMID:26851186
High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells., PMID:26785729
The novel function of CD82 and its impact on BCL2L12 via AKT/STAT5 signal pathway in acute myelogenous leukemia cells., PMID:26260387
The signal transducer and activator of transcription factors lodge in immunopathogenesis of rheumatoid arthritis., PMID:27215178
Hind limb unloading, a model of spaceflight conditions, leads to decreased B lymphopoiesis similar to aging., PMID:25376832
IL4 limits the efficacy of tumor-targeted antibody therapy in a murine model., PMID:25204776
BCR-ABL affects STAT5A and STAT5B differentially., PMID:24836440
Use of whole-blood transcriptomic profiling to highlight several pathophysiologic pathways associated with response to rituximab in patients with rheumatoid arthritis: data from a randomized, controlled, open-label trial., PMID:24756903
Constitutive activation of STAT5A and STAT5B regulates IgM secretion in Waldenstrom's macroglobulinemia., PMID:24335105
Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines., PMID:24192080
STAT5 and prolactin participate in a positive autocrine feedback loop that promotes angiogenesis., PMID:23729680
Differential contributions of STAT5A and STAT5B to stress protection and tyrosine kinase inhibitor resistance of chronic myeloid leukemia stem/progenitor cells., PMID:23400594
Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity., PMID:22378792
TSLP signaling network revealed by SILAC-based phosphoproteomics., PMID:22345495
For research use only. Not for human or drug use.
