Catalog No.
RHE34309
Species reactivity
Human, Mouse, Rat
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
IHC: 1:50-1:100
Target
Signal transducer and activator of transcription 1-alpha/beta, STAT1, Transcription factor ISGF-3 components p91/p84
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P42224
Applications
IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.5% BSA, 0.05% Sodium Azide and 50% Glycerol.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3K68
IGSF9-targeted therapy inhibits the progression of acute myeloid leukemia., PMID:40526840
TAP1 promotes immune escape by activating JNK/STAT1/PD-L1 signaling in EBV-associated gastric cancer., PMID:40500531
Expression of Immune-Related Genes and Possible Regulatory Mechanisms in Chronic Antibody-Mediated Rejection after Kidney Transplantation., PMID:40495508
Single-cell analysis of post-translational modifications identifies immunosuppressive macrophage subtypes in the HBV-positive hepatocellular carcinoma microenvironment., PMID:40455063
An activating Stat1 mutant disrupts normal STAT4 innate lymphocyte programs during viral infection., PMID:40446018
The role of IL-39 in autoimmune diseases: From general to immunopathogenesis., PMID:40440970
Anti-TNFα and Anti-IL-1β Monoclonal Antibodies Preserve BV-2 Microglial Homeostasis Under Hypoxia by Mitigating Inflammatory Reactivity and ATF4/MAPK-Mediated Apoptosis., PMID:40338234
Exploring the role of the CD74+ cardiac macrophage subset in trastuzumab cardiotoxicity and its mechanisms., PMID:40316056
Enhanced Immunity and Infection Resistance in Mice Through Co-Expression of Porcine IL-3, IL-7, and IL-15 Fusion Molecules in Yarrowia lipolytica., PMID:40282231
Type I IFN receptor blockade alleviates liver fibrosis through macrophage-derived STAT3 signaling., PMID:40260261
Targeting the poliovirus receptor to activate T cells and induce myeloid-derived suppressor cells to differentiate to pro-inflammatory macrophages via the IFN-γ-p-STAT1-IRF8 axis in cancer therapy., PMID:40229462
Genome and transcriptome sequencing for inborn errors of immunity: a feasible multi-omics diagnostic approach., PMID:40226629
CCL7 promotes macrophage polarization and synovitis to exacerbate rheumatoid arthritis., PMID:40224025
Differential replication, pathology, and immune response of clade IIb mpox virus in C57BL/6 and BALB/c mice., PMID:40130288
Baicalein Ameliorates Experimental Ulcerative Colitis Recurrency by Downregulating Neonatal Fc Receptor via the NF-κB Signaling Pathway., PMID:40124052
Enhanced T-cell immunity and lower humoral responses following 5-dose SARS-CoV-2 vaccination in patients with inborn errors of immunity compared with healthy controls., PMID:40114918
Single cell immunoprofile of synovial fluid in rheumatoid arthritis with TNF/JAK inhibitor treatment., PMID:40038288
Endothelial PPARδ Ablation Exacerbates Vascular Hyperpermeability via STAT1/CXCL10 Signaling in Acute Lung Injury., PMID:39996324
Inflammatory myopathy with abundant macrophage [IMAM]: Systemic analysis and pathological approach to distinguish it from dermatomyositis., PMID:39973451
The interplay of cancer-associated fibroblasts and apoptotic cancer cells suppresses lung cancer cell growth through WISP-1-integrin ανβ3-STAT1 signaling pathway., PMID:39966869
Critical role of Oas1g and STAT1 pathways in neuroinflammation: insights for Alzheimer's disease therapeutics., PMID:39953505
Tim-3 promotes viral infection by suppressing the USP25-TRAF3-IRF7 signaling pathway., PMID:39946759
The systemic lupus erythematosus-associated NCF190H allele synergizes with viral infection to cause mouse lupus but also limits virus spread., PMID:39939342
Caerin 1.1/1.9-mediated antitumor immunity depends on IFNAR-Stat1 signalling of tumour infiltrating macrophage by autocrine IFNα and is enhanced by CD47 blockade., PMID:39885296
Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation., PMID:39879840
Borrelia burgdorferi sensu lato inhibits CIITA transcription through pSTAT3 activation and enhanced SOCS1 and SOCS3 expression leading to limited IFN-γ production., PMID:39879745
Genomic profiling at a single center cracks the code in inborn errors of immunity., PMID:39873967
Interferon activation in bone marrow long-lived plasma cells in systemic lupus erythematosus., PMID:39867907
From phenotypic to molecular diagnosis: Insights from a clinical immunology service focused on inborn errors of immunity in Colombia., PMID:39836844
FAP upregulates PD-L1 expression in cancer-associated fibroblasts to exacerbate T cells dysfunction and suppress anti-tumor immunity., PMID:39828123
The JAK1/3 Inhibitor Tofacitinib Regulates Th Cell Profiles and Humoral Immune Responses in Myasthenia Gravis., PMID:39821232
Monoallelic expression can govern penetrance of inborn errors of immunity., PMID:39743591
Osteopontin neutralization increases vitamin D receptors on NKT cells and ameliorates liver fibrosis by promoting their activity., PMID:39654627
Leukemia inhibitory factor (LIF) receptor amplifies pathogenic activation of fibroblasts in lung fibrosis., PMID:39636853
NIR-II Imaging for Tracking the Spatiotemporal Immune Microenvironment in Atherosclerotic Plaques., PMID:39630481
PPAB001, a novel bispecific antibody against CD47 and CD24, enhances anti-PD-L1 efficacy in triple-negative breast cancer via reprogramming tumor-associated macrophages towards M1 phenotype., PMID:39622130
Macrophages are activated toward phagocytic lymphoma cell clearance by pentose phosphate pathway inhibition., PMID:39603243
Serum level of IFN-λ is elevated in idiopathic inflammatory myopathies., PMID:39579267
Corticosteroid effects on IL-10 and IL-1β in U937-derived macrophages: A model for Kawasaki disease-associated inflammation., PMID:39577337
The contribution of the CRP/CD64 axis to renal cancer progression by inducing protumor activation of tumor-associated macrophages., PMID:39564003
FOXA1 enhances antitumor immunity via repressing interferon-induced PD-L1 expression in nasopharyngeal carcinoma., PMID:39542656
IL-10 promotes Th17 cell differentiation by enhancing STAT1-dependent IL-6 production via IgE-stimulated mast cells., PMID:39496822
Pharmacological activation of STAT1-GSDME pyroptotic circuitry reinforces epigenetic immunotherapy for hepatocellular carcinoma., PMID:39486886
CD83 mediates the inhibitory effect of the S1PR1 agonist CYM5442 on LPS-induced M1 polarization of macrophages through the ERK-STAT-1 signaling pathway., PMID:39486189
Recurrent somatic mutations of FAT family cadherins induce an aggressive phenotype and poor prognosis in anaplastic large cell lymphoma., PMID:39478125
Cannabinoids shift the basal ganglia microRNA m 6 A methylation profile towards an anti-inflammatory phenotype in SIV-infected rhesus macaques., PMID:39416016
PGRN Inhibits Early B-cell Activation and IgE Production Through the IFITM3-STAT1 Signaling Pathway in Asthma., PMID:39412083
Protein kinase R induced by type I interferons is a main regulator of reactive microglia in Zika virus infection., PMID:39359232
Inhibition of CEACAM1 expression in cytokine-activated neutrophils using JAK inhibitors., PMID:39354368
Comprehensive antitumor immune response boosted by dual inhibition of SUMOylation and MEK in MYC-expressing KRAS-mutant cancers., PMID:39334463
For research use only. Not for human or drug use.
