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Anti-STAT3 Antibody (R3K43)

Catalog #:   RHE27707 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG1
Applications: IHC, WB
Accession: P40763
Overview

Catalog No.

RHE27707

Species reactivity

Human, Mouse, Rat

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

IHC: 1:50-1:100, WB: 1:500-1:1000

Target

Signal transducer and activator of transcription 3, APRF, STAT3, Acute-phase response factor

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P40763

Applications

IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.5% BSA, 0.05% Sodium Azide and 50% Glycerol.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3K43

Data Image
  • Immunohistochemical
    Immunohistochemistry analysis of paraffin-embedded Human Colon Caricnoma using STAT3 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
  • Western blot
    Western blot analysis of STAT3 in Hela, 3T3, PC-12 lysates using STAT3 antibody.
  • Western blot
    Western blot analysis of STAT3 in Jurkat, Raw264.7, Ramos, A549 lysates using Stat3 antibody.
References

Effects of Ganoderma spent substrate containing with polysaccharides and triterpenoids on the growth performance, antioxidant capacity and immunity level of chickens., PMID:40532998

Identifying pathogenic contributors of radiodermatitis ameliorated by Smad7-based targeting in canine and mouse models., PMID:40532891

STAT3 inhibition in combination with CD47 blockade inhibits osteosarcoma lung metastasis., PMID:40529368

Microneedle-based sustained release delivery of TNF-α/IL-6R dual-specific fenobody alleviates inflammation and promotes bone regeneration in rheumatoid arthritis rat model., PMID:40528840

Generation and Biological Characterization of an Anti-IL-6Rα Biosimilar Candidate Antibody., PMID:40524396

Glioportal: a comprehensive transcriptomic resource unveiling ligand-mediated mesenchymal transition in glioblastoma., PMID:40518441

OTUD1 downregulates PD-L1 expression by deubiquitinating STAT3 and promotes the immune response in CcRCC., PMID:40506611

RNase 7 and Th cytokines synergistically increase the secretion of interleukin-6 from keratinocytes., PMID:40461723

Cdc42 Activation in Anti-nephrin Antibody-Induced Nephropathy., PMID:40459930

Targeted tumor cell-intrinsic CTRP6 biomimetic codelivery synergistically amplifies ferroptosis and immune activation to boost anti-PD-L1 immunotherapy efficacy in lung cancer., PMID:40457410

The role of IL-39 in autoimmune diseases: From general to immunopathogenesis., PMID:40440970

Inhibition of MCP1 (CCL2) Enhances Antitumor Activity of NK Cells Against HCC Cells Under Hypoxia., PMID:40430040

Biological and Clinical Relevance of Genetic Alterations in Peripheral T-cell Lymphomas., PMID:40416001

CD19+IL-10+ regulatory B cells induced by IL-12p35 regulates functional T-cell subsets in patients with immune thrombocytopenia., PMID:40415408

Clostridium difficile as a potent trigger of colorectal carcinogenesis., PMID:40411629

VSIG4 Promotes Tumour-Associated Macrophage M2 Polarization and Immune Escape in Colorectal Cancer via Fatty Acid Oxidation Pathway., PMID:40405491

Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity., PMID:40399681

Autoimmune enteropathy associated with T cell large granular lymphocytic leukemia in a patient with BACH2 mutation: a case report., PMID:40386599

Glycosylation-driven programs coordinate immunoregulatory and pro-angiogenic functions of myeloid-derived suppressor cells., PMID:40381622

IL-11/IL-11R signal inhibition by 9MW3811 remodels immune tumor microenvironment and enhances anti-tumor efficacy of PD-1 blockade., PMID:40355638

BAP1-mediated ubiquitination inhibition and CAS6/AXL signaling activation in bladder cancer progression., PMID:40330545

Increased protein expression of interleukin-10 and its signalling molecules in colon cancer progression: potential prognostic and therapeutic targets., PMID:40299210

PLOD1 promotes the malignancy of hepatocellular carcinoma by facilitating the NF-κB/IL-6/STAT3-dependent TCA cycle., PMID:40290518

CTLA4 modulates B cell receptor signals to inhibit HBsAb secretion in chronic hepatitis B patients., PMID:40279930

Type I IFN receptor blockade alleviates liver fibrosis through macrophage-derived STAT3 signaling., PMID:40260261

Multiple myeloma with 1q gain/amplification exhibits reduced CD38 expression via interleukin-6 receptor overexpression., PMID:40259818

JAK3 A573V and JAK3 M511I mutations in peripheral T-cell lymphoma mediating resistance to anti-PD-1 therapy through the STAT3/PD-L1 pathway., PMID:40199606

A novel IgD-FcδR blocker, IgD-Fc-Ig fusion protein, effectively alleviates abnormal activation of T cells the disease progression in systemic lupus erythematosus., PMID:40194603

APOC1 expressed in macrophages promotes the pulmonary metastasis of colorectal cancer via CCL2/CCL5., PMID:40194454

Unveiling the Role of JAK2/STAT3 signaling in chemoresistance of gynecological cancers: From mechanisms to therapeutic implications., PMID:40187711

Analysis of mutually exclusive expression in cancer cells identifies a previously unknown intergenic regulatory paradigm., PMID:40186387

Circulating miR-485-3p as a biomarker for VEGF-associated therapeutic response to atezolizumab plus bevacizumab in hepatocellular carcinoma., PMID:40180668

Functional insights of an uncommon hypomorphic variant in IL2RG as a monogenic cause of CVID-like disease with antibody deficiency and T CD4 lymphopenia., PMID:40170851

The effects of interleukin-35 and interleukin-10 on pulmonary inflammation and fibrosis in a bleomycin-induced systemic sclerosis mouse model., PMID:40153333

Brusatol ameliorates intestinal mucosal injury in ulcerative colitis via activating IL-22/STAT3 pathway., PMID:40101416

Fibrinogen-like 2 in tumor-associated macrophage-derived extracellular vesicles shapes an immunosuppressive microenvironment in colorectal liver metastases by promoting tumor stemness and neutrophil extracellular traps formation., PMID:40097065

Dynamic responses to rejection in the transplanted human heart revealed through spatial transcriptomics., PMID:40093136

ROS-dependent SOCS3 upregulation disrupts regulatory T cell stability during autoimmune disease development., PMID:40090133

BRD7 Inhibited Immune Escape in Nasopharyngeal Carcinoma via Inhibiting PD-L1 Expression., PMID:40083706

Hyper IgE Syndrome: Bridging the Gap Between Immunodeficiency, Atopy, and Allergic Diseases., PMID:40082265

Monocytes from patients with myelodysplastic syndrome inhibit natural killer cell-mediated antitumor function through the CD200/CD200R pathway., PMID:40049088

Jieyu Guben decoction alleviates combined allergic rhinitis and asthma syndrome by balancing Th17/Treg expression and restoring PPARD., PMID:40031093

BTK inhibitors enhance NKG2D ligand expression by regulating IL-10/STAT3 pathway in activated non-GCB diffuse large B-cell lymphoma cells., PMID:40029697

TLR-4Ab and IFNγAb with exogenous IL-10 treated LPS induced mice shown differential inflammatory response upon RANKL-M-CSF stimulation in resident bone marrow cells., PMID:40023455

Gastric-type endocervical adenocarcinoma, superficial myofibroblastoma, sex cord-stromal tumors, and HSIL in Peutz-Jeghers syndrome: a rare case report, genetic characterization, and review of literature., PMID:40018404

Synergistic role of gut-microbial L-ornithine in enhancing ustekinumab efficacy for Crohn's disease., PMID:39978335

Potential Modulatory Effects of Hesperidin on the JAK/STAT Pathway in Mesangial Proliferative Glomerulonephritis., PMID:39928525

Characterisation of the antinociceptive effect of baricitinib in the collagen antibody-induced arthritis mouse model., PMID:39924372

Molecular basis for the disease-modifying effects of belimumab in systemic lupus erythematosus and molecular predictors of early response: blood transcriptome analysis implicates the innate immunity and DNA damage response pathways., PMID:39919899

Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy., PMID:39893129

Datasheet

Document Download

Anti-STAT3 Antibody (R3K43).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

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Anti-STAT3 Antibody (R3K43) [RHE27707]
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