Catalog No.
RHE27706
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
IHC: 1:50-1:100
Target
Signal transducer and activator of transcription 3, APRF, STAT3, Acute-phase response factor
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P40763
Applications
IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.5% BSA, 0.05% Sodium Azide and 50% Glycerol.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3K42
NF-κB and STAT3 activation in CD4 T cells in pediatric MOG antibody-associated disease., PMID:37770354
Maternal pre-eclampsia serum increases neurite growth and mitochondrial function through a potential IL-6-dependent mechanism in differentiated SH-SY5Y cells., PMID:36714304
Activation of STAT3 (signal transducer and activator of transcription 3) in synovial tissues from the hip joint in the early stage of rapidly destructive coxopathy., PMID:36244795
Luteolin suppresses the growth of colon cancer cells by inhibiting the IL-6/STAT3 signaling pathway., PMID:36092354
G-CSF and IL-6 may be involved in formation of endometriosis lesions by increasing the expression of angiogenic factors in neutrophils., PMID:34643696
Acute FPIES reactions are associated with an IL-17 inflammatory signature., PMID:33891982
LRP8 activates STAT3 to induce PD-L1 expression in osteosarcoma., PMID:33054597
Phloretin Modulates Human Th17/Treg Cell Differentiation In Vitro via AMPK Signaling., PMID:32802861
TGF-β pathway activation by idiopathic pulmonary fibrosis (IPF) fibroblast derived soluble factors is mediated by IL-6 trans-signaling., PMID:32070329
Physiological strength electric fields modulate human T cell activation and polarisation., PMID:31772211
Snail expression contributes to temozolomide resistance in glioblastoma., PMID:31396334
IL-6-PAD4 axis in the earliest phase of arthritis in knock-in gp130F759 mice, a model for rheumatoid arthritis., PMID:31321075
IL-37 attenuates allergic process via STAT6/STAT3 pathways in murine allergic rhinitis., PMID:30665041
Interleukin-22 Promotes Osteosarcoma Cell Proliferation and Invasion via STAT3 Activation., PMID:30381753
Leukemia inhibitory factor functions in parallel with interleukin-6 to promote ovarian cancer growth., PMID:30305729
Red nucleus interleukin-1β evokes tactile allodynia through activation of JAK/STAT3 and JNK signaling pathways., PMID:30216497
Interleukin-6 receptor inhibitor suppresses bone metastases in a breast cancer cell line., PMID:29557068
Celastrol mediates Th17 and Treg cell generation via metabolic signaling., PMID:29476742
Up-Regulation of CX3CL1 via STAT3 Contributes to SMIR-Induced Chronic Postsurgical Pain., PMID:29313211
An Interleukin-6 Receptor Antibody Suppresses Atherosclerosis in Atherogenic Mice., PMID:29312959
Red nucleus interleukin-6 participates in the maintenance of neuropathic pain through JAK/STAT3 and ERK signaling pathways., PMID:29183675
Impairment of Hepcidin Upregulation by Lipopolysaccharide in the Interleukin-6 Knockout Mouse Brain., PMID:29163042
C-X-C motif chemokine receptor 4 promotes tumor angiogenesis in gastric cancer via activation of JAK2/STAT3., PMID:28544312
The role of STAT3 and AhR in the differentiation of CD4+ T cells into Th17 and Treg cells., PMID:28445259
Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model., PMID:27980102
The role of local IL6/JAK2/STAT3 signaling in high glucose-induced podocyte hypertrophy., PMID:27957415
IL-6-specific autoantibodies among APECED and thymoma patients., PMID:27957331
The immunomodulatory effects of TNF-α inhibitors on human Th17 cells via RORγt histone acetylation., PMID:27926504
Role of mTOR signaling pathway in the pathogenesis of subependymal giant cell astrocytoma - A study of 28 cases., PMID:27625244
Modeling anti-IL-6 therapy using breast cancer patient-derived xenografts., PMID:27602583
Expression of biologically active bovine interleukin 7 and evaluating the activity in vitro., PMID:27051202
Obesity decreases B cell responses in young and elderly individuals., PMID:26857091
Bidirectional role of IL-6 signal in pathogenesis of lung fibrosis., PMID:26289430
Anti-proliferative action of IL-6R-targeted antibody tocilizumab for non-small cell lung cancer cells., PMID:26137057
CCR5 Blockade Suppresses Melanoma Development Through Inhibition of IL-6-Stat3 Pathway via Upregulation of SOCS3., PMID:26047948
TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways., PMID:25192910
Polarization of prostate cancer-associated macrophages is induced by milk fat globule-EGF factor 8 (MFG-E8)-mediated efferocytosis., PMID:25006249
Interleukin-17 increases the expression of Toll-like receptor 3 via the STAT3 pathway in rheumatoid arthritis fibroblast-like synoviocytes., PMID:24708416
The amelioration of phagocytic ability in microglial cells by curcumin through the inhibition of EMF-induced pro-inflammatory responses., PMID:24645646
STAT3 but not STAT1 is required for astrocyte differentiation., PMID:24466267
Lactobacillus rhamnosus (LGG) regulates IL-10 signaling in the developing murine colon through upregulation of the IL-10R2 receptor subunit., PMID:23272193
Innate immune responses involving natural killer and natural killer T cells promote liver regeneration after partial hepatectomy in mice., PMID:23086918
Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12., PMID:22530037
Cell-type-specific expression of STAT transcription factors in tissue samples from patients with lymphocytic thyroiditis., PMID:22527947
Dovitinib sensitizes hepatocellular carcinoma cells to TRAIL and tigatuzumab, a novel anti-DR5 antibody, through SHP-1-dependent inhibition of STAT3., PMID:22230479
Regulation of STAT3 by histone deacetylase-3 in diffuse large B-cell lymphoma: implications for therapy., PMID:22116549
Nuclear localization of activated STAT6 and STAT3 in epidermis of prurigo nodularis., PMID:21711341
HGF/c-met/Stat3 signaling during skin tumor cell invasion: indications for a positive feedback loop., PMID:21595927
Anti-dermatitis effects of oak wood vinegar on the DNCB-induced contact hypersensitivity via STAT3 suppression., PMID:21511023
Cancer-related inflammation and Barrett's carcinogenesis: interleukin-6 and STAT3 mediate apoptotic resistance in transformed Barrett's cells., PMID:21148399
For research use only. Not for human or drug use.
