Catalog No.
RHE24802
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
IHC: 1:50-1:200, WB: 1:500-1:1000
Target
hGDNF, Astrocyte-derived trophic factor, Glial cell line-derived neurotrophic factor, ATF, GDNF
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P39905
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3K21
Reactive Astrocytes Release GDNF to Promote Brain Recovery and Neuronal Survival Following Ischemic Stroke., PMID:40085335
Molecular and Functional Significance of Growth Differentiation Factor-15: A Review on Cardiovascular-Kidney-Metabolic Biomarker., PMID:39781722
The neurotrophic factor artemin and its receptor GFRα3 mediate migraine-like pain via the ion channel TRPM8., PMID:39552306
Inhibition of GDNF-Driven Macrophage-to-Myofibroblast Transition Protects Against Colitis-Associated Intestinal Fibrosis., PMID:39500861
Neurons enhance blood-brain barrier function via upregulating claudin-5 and VE-cadherin expression due to glial cell line-derived neurotrophic factor secretion., PMID:39475379
Distinct Non-Human Leukocyte Antigen Antibody Signatures Correlate with Endothelial Crossmatch Status in Lung and Renal Transplant Recipients., PMID:39408890
GB18-06, a nanobody targeting GDF15, effectively alleviates weight loss and restores physical function in cachexia models., PMID:39400041
Nuclear Magnetic Resonance Treatment Induces ßNGF Release from Schwann Cells and Enhances the Neurite Growth of Dorsal Root Ganglion Neurons In Vitro., PMID:39329728
FK962 protects retinal ganglion cell under hypoxia/reoxygenation: Possible involvement of glial cell line-derived neurotrophic factor signaling pathway., PMID:39284507
Neutralizing antibody against GDF15 for treatment of cancer-associated cachexia., PMID:39172988
The forensic aspects of suicide and neurotrophin factors: a research study., PMID:39170712
Striatal GDNF Neurons Chemoattract RET-Positive Dopamine Axons at Seven Times Farther Distance Than Medium Spiny Neurons., PMID:38920687
Effect of Temperature on the Development of Stages of Spermatogenesis and the Functionality of Sertoli Cells In Vitro., PMID:38396838
Schwann cells modulate nociception in neurofibromatosis 1., PMID:38258905
Vascular and Non-HLA autoantibody profiles in hospitalized patients with COVID-19., PMID:37398658
GDNF family receptor alpha-like antagonist antibody alleviates chemotherapy-induced cachexia in melanoma-bearing mice., PMID:37017344
The central glial cell line-derived neurotrophic factor (GDNF) regulates pulmonary function in asthmatic rats., PMID:36819542
Lipocalin-2 Is a Key Regulator of Neuroinflammation in Secondary Traumatic and Ischemic Brain Injury., PMID:36508119
The sigma-1 receptor curtails endogenous opioid analgesia during sensitization of TRPV1 nociceptors., PMID:36478100
The GDF15-GFRAL axis mediates chemotherapy-induced fatigue in mice., PMID:36427806
The neuroprotective effects of glucagon-like peptide 1 in Alzheimer's and Parkinson's disease: An in-depth review., PMID:36117625
Transfer of neuron-derived α-synuclein to astrocytes induces neuroinflammation and blood-brain barrier damage after methamphetamine exposure: Involving the regulation of nuclear receptor-associated protein 1., PMID:36089218
Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice., PMID:35492247
Camptothecin effectively treats obesity in mice through GDF15 induction., PMID:35202387
Tumoral Neuroligin 1 Promotes Cancer-Nerve Interactions and Synergizes with the Glial Cell Line-Derived Neurotrophic Factor., PMID:35053395
Decreased Expression of Glial-Derived Neurotrophic Factor Receptors in Glaucomatous Human Retinas., PMID:34738835
Targeting neurotrophic factors for low back pain and sciatica: a systematic review and meta-analysis., PMID:34677587
Necroptotic astrocytes induced neuronal apoptosis partially through EVs-derived pro-BDNF., PMID:34555432
Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15., PMID:34187898
Neurotrophic Factors in Parkinson's Disease: Clinical Trials, Open Challenges and Nanoparticle-Mediated Delivery to the Brain., PMID:34149364
The effect of biodegradable silk fibroin-based scaffolds containing glial cell line-derived neurotrophic factor (GDNF) on the corneal regeneration process., PMID:34119551
Pimavanserin Promotes Trophic Factor Release and Protects Cultured Primary Dopaminergic Neurons Exposed to MPP+ in a GDNF-Dependent Manner., PMID:34032411
Serum Cytokine Profiling Identifies Axl as a New Biomarker Candidate for Active Eosinophilic Granulomatosis With Polyangiitis., PMID:33987203
Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation., PMID:33903632
Cyclophosphamide suppresses spermatogenesis in the testis of mice through downregulation of miR-34b and miR-34c., PMID:33900636
Identification of cell surface targets for CAR-T cell therapies and antibody-drug conjugates in breast cancer., PMID:33838601
Adoptive T cell immunotherapy for medullary thyroid carcinoma targeting GDNF family receptor alpha 4., PMID:33614919
Mesenchymal Stem Cells Derived from Wharton's Jelly Can Differentiate into Schwann Cell-Like Cells and Promote Peripheral Nerve Regeneration in Acellular Nerve Grafts., PMID:33515168
Dental pulp stem cells stimulate neuronal differentiation of PC12 cells., PMID:33510089
Overexpression of GDNF and FGF-1 in Canine Benign Prostatic Hyperplasia: Evidence for a Pathogenetic Role of Neural Growth Factor., PMID:33494907
Amantadine Alleviates Postoperative Cognitive Dysfunction Possibly by Preserving Neurotrophic Factor Expression and Dendritic Arborization in the Hippocampus of Old Rodents., PMID:33324197
Human splenic TER cells: A relevant prognostic factor acting via the artemin-GFRα3-ERK pathway in pancreatic ductal adenocarcinoma., PMID:33236361
Do serum GDNF levels correlate with severity of Alzheimer's disease?, PMID:33215334
GDNF secreted by pre-osteoclasts induces migration of bone marrow mesenchymal stem cells and stimulates osteogenesis., PMID:33148376
Safety Assessment of AAV2-hGDNF Administered Via Intracerebral Injection in Rats for Treatment of Parkinson's Disease., PMID:33131343
From the Gut to the Brain and Back: Therapeutic Approaches for the Treatment of Network Dysfunction in Parkinson's Disease., PMID:33117258
In Vitro and In Vivo Determinations of The Anti-GDNF Family Receptor Alpha 1 Antibody in Mice by Immunochemistry and RT-PCR., PMID:33098391
Isolation, identification and differentiation of human spermatogonial cells on three-dimensional decellularized sheep testis., PMID:32992121
Memantine ameliorates motor impairments and pathologies in a mouse model of neuromyelitis optica spectrum disorders., PMID:32782018
Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice., PMID:32661391
For research use only. Not for human or drug use.
