Catalog No.
RHE17401
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IHC: 1:200-1:1000
Target
TCF-1, TCF-7, TCF7, TCF1, T-cell factor 1, T-cell-specific transcription factor 1, Transcription factor 7
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P36402
Applications
ELISA, FCM, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3K03
Single cell multi-omics reveals re-dosing with CD3 bispecific antibody induces a TCF7 high central memory CD8 + T cell population associated with reduced cytokine production., PMID:40168725
CD38 in the pathobiology of cutaneous T-cell lymphoma and the potential for combination therapeutic intervention., PMID:40057636
Distinct cellular mechanisms underlie chemotherapies and PD-L1 blockade combinations in triple-negative breast cancer., PMID:39919737
Metabolic-Immune Suppression Mediated by the SIRT1-CX3CL1 Axis Induces Functional Enhancement of Regulatory T Cells in Colorectal Carcinoma., PMID:39783838
Cone-rod homeobox transcriptionally activates TCF7 to promote the proliferation of retinal pigment epithelial and retinoblastoma cells in vitro., PMID:39559312
Identification of different functions of CD8+ T cell subpopulations by a novel monoclonal antibody., PMID:38922845
Glycoengineering-based anti-PD-1-iRGD peptide conjugate boosts antitumor efficacy through T cell engagement., PMID:38843844
Novel chimeric antigen receptor-expressing T cells targeting the malignant mesothelioma-specific antigen sialylated HEG1., PMID:38212893
Mass cytometry and transcriptomic profiling reveal PD1 blockade induced alterations in oral carcinogenesis., PMID:38085124
CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4+ T cells., PMID:37161048
Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade., PMID:37001526
Rgs16 promotes antitumor CD8+ T cell exhaustion., PMID:35622904
Dual checkpoint blockade of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes antitumor immunity., PMID:34599020
A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer., PMID:33958794
Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation., PMID:33128876
Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control., PMID:32760119
Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ., PMID:31519911
Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1-CD8+ Tumor-Infiltrating T Cells., PMID:30635236
Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma., PMID:30388456
Human Lymph Nodes Maintain TCF-1hi Memory T Cells with High Functional Potential and Clonal Diversity throughout Life., PMID:30111633
Sclerostin Antibody Reverses the Severe Sublesional Bone Loss in Rats After Chronic Spinal Cord Injury., PMID:29931461
Regulatory network reconstruction reveals genes with prognostic value for chronic lymphocytic leukemia., PMID:26606983
Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis., PMID:26515592
Cell-Intrinsic gp130 Signaling on CD4+ T Cells Shapes Long-Lasting Antiviral Immunity., PMID:26085685
TRIB2 acts downstream of Wnt/TCF in liver cancer cells to regulate YAP and C/EBPα function., PMID:23769673
Parity induces differentiation and reduces Wnt/Notch signaling ratio and proliferation potential of basal stem/progenitor cells isolated from mouse mammary epithelium., PMID:23621987
New monoallelic (partial tandem duplication) mutation of HNF1a gene in steatotic hepatocellular adenoma., PMID:21566527
Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation., PMID:19515997
Transcriptional regulation of SM22alpha by Wnt3a: convergence with TGFbeta(1)/Smad signaling at a novel regulatory element., PMID:19344627
Family-based association analysis implicates IL-4 in susceptibility to Kawasaki disease., PMID:15889128
Ectopic activation of lymphoid high mobility group-box transcription factor TCF-1 and overexpression in colorectal cancer cells., PMID:9259402
The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes., PMID:7579399
Circumvention of tolerance for the nuclear T cell protein TCF-1 by immunization of TCF-1 knock-out mice., PMID:8530156
For research use only. Not for human or drug use.
