Catalog No.
YHD45501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys26-Ile243
Predicted molecular weight
26.96 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P21399
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Ferritin repressor protein, IRP1, ACO1, IREB1, Citrate hydro-lyase, IRE-BP 1, Iron-responsive element-binding protein 1, Aconitase, Cytoplasmic aconitate hydratase, Iron regulatory protein 1
The thioredoxin-like and one glutaredoxin domain are required to rescue the iron-starvation phenotype of HeLa GLRX3 knock out cells., PMID:40400140
The Cia1 and Cia2 subunits of the CTC mediate recognition of apo-FeS proteins with a C-terminal targeting complex recognition motif., PMID:40196589
Yeast Hsp78 plays an essential role in adapting to severe ethanol stress via mild ethanol stress pretreatment in mitochondrial protein quality control., PMID:40187374
Light regulates seed dormancy through FHY3-mediated activation of ACC OXIDASE 1 in Arabidopsis., PMID:40082285
α-Synuclein Iron-Responsive-Element RNA and Iron Regulatory Protein Affinity Is Specifically Reduced by Iron in Parkinson's Disease., PMID:40001517
Autophagy induced by mechanical stress sensitizes cells to ferroptosis by NCOA4-FTH1 axis., PMID:39988734
Identification of selective sweep and associated QTL traits in Iranian Ovis aries and Ovis orientalis populations., PMID:39748948
In-Gel Activity Assay of Mammalian Mitochondrial and Cytosolic Aconitases, Surrogate Markers of Compartment-Specific Oxidative Stress and Iron Status., PMID:39677021
Iron regulatory protein 1-deficient mice exhibit hypospermatogenesis., PMID:39667502
Effect of elevated ammonium on biotic and abiotic stress defense responses and expression of related genes in cucumber (Cucumis sativus L.) plants., PMID:39577162
A bulge uridine in the HIF2α IRE allows IRP1 but not IRP2 to selectively regulate HIF2α expression and ensuing EPO levels., PMID:39316647
Iron regulatory protein 1 is required for the propagation of inflammation in inflammatory bowel disease., PMID:39122013
Apolipoprotein E deficiency leads to the polarization of splenic macrophages towards M1 phenotype by increasing iron content., PMID:39103538
Alpha-synuclein affects certain iron transporters of BV2 microglia cell through its ferric reductase activity., PMID:38919150
Genome-wide identification and analysis of epithelial-mesenchymal transition-related RNA-binding proteins and alternative splicing in a human breast cancer cell line., PMID:38783078
Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms., PMID:38773499
Using Biotinylated Iron-Responsive Element to Analyze the Activity of Iron Regulatory Proteins., PMID:38732071
Influences of Ipomoea batatas Anti-Cancer Peptide on Tomato Defense Genes., PMID:38698748
MEMO1 binds iron and modulates iron homeostasis in cancer cells., PMID:38640016
Cell density impacts the susceptibility to ferroptosis by modulating IRP1-mediated iron homeostasis., PMID:38382918
Iron regulatory proteins 1 and 2 have opposing roles in regulating inflammation in bacterial orchitis., PMID:38301068
Nuclear translocation of STAT5 initiates iron overload in huntington's disease by up-regulating IRP1 expression., PMID:38261161
Epidermal turnover and iron metabolism in senile lentigo., PMID:38217362
Contrasting Iron Metabolism in Undifferentiated Versus Differentiated MO3.13 Oligodendrocytes via IL-1β-Induced Iron Regulatory Protein 1., PMID:37917337
Characterization of MicroRNAs and Gene Expression in ACC Oxidase RNA Interference-Based Transgenic Bananas., PMID:37836154
Iron regulatory protein 1: the deadly switch of ferroptosis., PMID:37721261
A novel and independent survival prognostic model for OSCC: the functions and prognostic values of RNA-binding proteins., PMID:37656222
GhXB38D represses cotton fibre elongation through ubiquitination of ethylene biosynthesis enzymes GhACS4 and GhACO1., PMID:37596974
The transcription factor EMB1444-like affects tomato fruit ripening by regulating YELLOW-FRUITED TOMATO 1, a core component of ethylene signaling transduction., PMID:37555619
Inosine enhances tumor mitochondrial respiration by inducing Rag GTPases and nascent protein synthesis under nutrient starvation., PMID:37532694
Trihelix transcription factor SlGT31 regulates fruit ripening mediated by ethylene in tomato., PMID:37527459
IRP1 mediated ferroptosis reverses temozolomide resistance in glioblastoma via affecting LCN2/FPN1 signaling axis depended on NFKB2., PMID:37520713
Identification of potential ferroptosis-associated biomarkers in rheumatoid arthritis., PMID:37492576
H2S regulation of iron homeostasis by IRP1 improves vascular smooth muscle cell functions., PMID:37487913
Targeted system approach to ethylene biosynthesis and signaling of a heat tolerant tomato cultivar; the impact of growing season on fruit ripening., PMID:37457344
The impact of RNA binding proteins and the associated long non-coding RNAs in the TCA cycle on cancer pathogenesis., PMID:37221841
Expression of genes related to iron homeostasis in breast cancer., PMID:37119411
Mechanisms of enhanced renal and hepatic erythropoietin synthesis by sodium-glucose cotransporter 2 inhibitors., PMID:37086098
Iron response elements (IREs)-mRNA of Alzheimer's amyloid precursor protein binding to iron regulatory protein (IRP1): a combined molecular docking and spectroscopic approach., PMID:36977734
Ferrodifferentiation regulates neurodevelopment via ROS generation., PMID:36929272
Downregulation of hepcidin by norcantharidin in macrophage., PMID:36855296
Optimization of Biotinylated RNA or DNA Pull-Down Assays for Detection of Binding Proteins: Examples of IRP1, IRP2, HuR, AUF1, and Nrf2., PMID:36835018
Protective Effect of Sevoflurane Preconditioning on Cardiomyocytes Against Hypoxia/Reoxygenation Injury by Modulating Iron Homeostasis and Ferroptosis., PMID:36800141
Red clover (Trifolium pratense L.) extract inhibits ferroptotic cell death by modulating cellular iron homeostasis., PMID:36796742
Iron Regulatory Protein 1 is Required for the Propagation of Inflammation in Inflammatory Bowel Disease., PMID:36789413
Osteoporotic bone loss from excess iron accumulation is driven by NOX4-triggered ferroptosis in osteoblasts., PMID:36738798
Morphophysiological and transcriptome analysis reveal that reprogramming of metabolism, phytohormones and root development pathways governs the potassium (K+) deficiency response in two contrasting chickpea cultivars., PMID:36714783
Baicalein Attenuates Brain Iron Accumulation through Protecting Aconitase 1 from Oxidative Stress in Rotenone-Induced Parkinson's Disease in Rats., PMID:36670874
Prion Mutations in Republic of Republic of Korea, China, and Japan., PMID:36614069
[Effect of electroacupuncture of "Weizhong" (BL40) on iron metabolism disorder in rats with lumbar multifidus muscle injury]., PMID:36571222
For research use only. Not for human or drug use.
