Catalog No.
RHE07802
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000, IHC: 1:200-1:1000
Target
RING finger protein 51, BMI1, RNF51, Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, PCGF4
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P35226
Applications
ELISA, FCM, IF, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3J71
Thymic Bmi-1 hampers γδT17 generation and its derived RORγt-IL-17A signaling to delay cardiac aging., PMID:40366697
The transcription repressor Bach2 is required for maintaining the B-1 cell population by regulating self-renewal., PMID:40170867
Hedgehog Pathway Is a Regulator of Stemness in HER2-Positive Trastuzumab-Resistant Breast Cancer., PMID:39596169
Antibody conjugated targeted nanotherapy epigenetically inhibits calpain-mediated mitochondrial dysfunction to attenuate Parkinson's disease., PMID:39245478
Characterization of immortalized ovarian epithelial cells with BRCA1/2 mutation., PMID:38615309
Correlation between intestinal stem cell niche changes and small bowel crypt failure in patients with treatment-naïve celiac disease., PMID:38427764
BMI1 regulates human erythroid self-renewal through both gene repression and gene activation., PMID:38370741
The immunology of corneal limbal stem cells: the up-to-date approach to stem cell transplantation., PMID:37901870
Targeting BMI-1 to deplete antibody-secreting cells in autoimmunity., PMID:37799772
SOX18 meditates the resistance of Bmi1-expressing cells to cetuximab in HNSCC., PMID:37184032
Chondroitin Sulphate/Dermatan Sulphate Proteoglycans: Potential Regulators of Corneal Stem/Progenitor Cell Phenotype In Vitro., PMID:36768414
Age disparities in intestinal stem cell quantities: a possible explanation for preterm infant susceptibility to necrotizing enterocolitis., PMID:36208323
Targeting BMI-1 in B cells restores effective humoral immune responses and controls chronic viral infection., PMID:34845392
MiR-342-3p inhibits LCSC oncogenicity and cell stemness through HDAC7/PTEN axis., PMID:34842937
Targeting LSD1 suppresses stem cell-like properties and sensitizes head and neck squamous cell carcinoma to PD-1 blockade., PMID:34689153
The IL-6R and Bmi-1 axis controls self-renewal and chemoresistance of head and neck cancer stem cells., PMID:34689150
Administration of cyclophosphamide to rats induces pica and potentiates 5-hydroxytryptamine synthesis in the intestine without causing severe intestinal injury., PMID:34507634
Endoplasmic reticulum stress inhibits 3D Matrigel-induced vasculogenic mimicry of breast cancer cells via TGF-β1/Smad2/3 and β-catenin signaling., PMID:34320274
CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance., PMID:33945793
hTERT-Driven Immortalization of RDEB Fibroblast and Keratinocyte Cell Lines Followed by Cre-Mediated Transgene Elimination., PMID:33916959
Upregulating hsa-miR-128a Increased the Effects of Pembrolizumab on Laryngeal Cancer Cells via the p53 Pathway., PMID:33791361
The effect of fibroblast growth factor 7 on human dental pulp stem cells for differentiation to AQP5-positive and αSMA-positive cells in vitro and in vivo., PMID:33783980
G-quadruplexes originating from evolutionary conserved L1 elements interfere with neuronal gene expression in Alzheimer's disease., PMID:33758195
IL-21 Promotes Intestinal Memory IgA Responses., PMID:32859726
Stem Cell Marker Expression in Early Stage Colorectal Cancer is Associated with Recurrent Intestinal Neoplasia., PMID:32647988
Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes., PMID:32584970
IL1R2 Blockade Suppresses Breast Tumorigenesis and Progression by Impairing USP15-Dependent BMI1 Stability., PMID:31921558
Identification and chemoresistance of cancer stem cells in HPV-negative oropharyngeal cancer., PMID:31897209
Precision medicine for human cancers with Notch signaling dysregulation (Review)., PMID:31894255
Shark tooth regeneration reveals common stem cell characters in both human rested lamina and ameloblastoma., PMID:31685919
E-cadherin-Fc chimera protein matrix enhances cancer stem-like properties and induces mesenchymal features in colon cancer cells., PMID:31505062
Antibody-drug conjugate T-DM1 treatment for HER2+ breast cancer induces ROR1 and confers resistance through activation of Hippo transcriptional coactivator YAP1., PMID:31085100
The expression and prognostic value of stem cell markers Bmi-1, HESC5:3, and HES77 in human papillomavirus-positive and -negative oropharyngeal squamous cell carcinoma., PMID:30915904
Transformation of mature mouse B cells into malignant plasma cells in vitro via introduction of defined genetic elements., PMID:30664244
Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody., PMID:30622177
The Polycomb BMI1 Protein Is Co-expressed With CD26+ in Leukemic Stem Cells of Chronic Myeloid Leukemia., PMID:30574454
Gankyrin Contributes to Tumorigenesis and Chemoresistance in Sporadic Colorectal Cancer., PMID:30513515
Combined detection of serum autoantibodies as diagnostic biomarkers in esophagogastric junction adenocarcinoma., PMID:30426295
Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma., PMID:30297829
Bevacizumab with dose-dense paclitaxel/carboplatin as first-line chemotherapy for advanced ovarian cancer., PMID:30059681
Monoclonal Antibodies Reveal Dynamic Plasticity Between Lgr5- and Bmi1-Expressing Intestinal Cell Populations., PMID:29928673
Effect of Bmi-1-mediated NF-κB signaling pathway on the stem-like properties of CD133+ human liver cancer cells., PMID:29843222
Abundant expression of BMI1 in follicular lymphoma is associated with reduced overall survival., PMID:29251058
Bmi‑1‑targeting suppresses osteosarcoma aggressiveness through the NF‑κB signaling pathway., PMID:28983587
Bispecific antibody suppresses osteosarcoma aggressiveness through regulation of NF-κB signaling pathway., PMID:28631557
Intestinal Epithelial Stem Cells: Distinct Behavior After Surgical Injury and Teduglutide Administration., PMID:28362133
MicroRNA-194 represses glioma cell epithelial‑to‑mesenchymal transition by targeting Bmi1., PMID:28098896
Identification, expansion and characterization of cancer cells with stem cell properties from head and neck squamous cell carcinomas., PMID:27619333
Heterogeneity in readouts of canonical wnt pathway activity within intestinal crypts., PMID:27264700
Bmi1 inhibition enhances the sensitivity of pancreatic cancer cells to gemcitabine., PMID:27177084
For research use only. Not for human or drug use.
