Catalog No.
YHD45201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser2-Pro274
Predicted molecular weight
32.90 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P21333
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ABP-280, Actin-binding protein 280, Non-muscle filamin, FLN, FLN1, Filamin-A, FLNA, Filamin-1, Endothelial actin-binding protein, Alpha-filamin, FLN-A
Unveiling the Potential Binding Targets of Celastrol in Colorectal Cancer: A Proteomic Profiling Approach Integrating Cellular Thermal Shift Assay and Pulse Proteolysis., PMID:40480957
Dragon's Blood Modulates Disulfidptosis-Related Genes to Alleviate Ischemic Brain Injury in Mice., PMID:40478465
Filamin A editing in myeloid cells reduces intestinal inflammation and protects from colitis., PMID:40471139
Structural Basis of the LARP4-Filamin A Interaction and Competition with Integrin β7 Tails., PMID:40466905
Efficient delivery of small RNAs to podocytes in vitro by direct exosome transfection., PMID:40410889
Transcriptomic characterization of the synergy between human induced pluripotent stem cells-derived liver- and pancreas-on-chip coculture., PMID:40409528
Filamin A in focus: unravelling the multifaceted roles of filamin A in neurodevelopment and neurological disorders., PMID:40365811
Identifying potential tear biomarkers in premature infants with retinopathy of prematurity based on proteome and transcriptome analysis., PMID:40343554
Suppression of SRC protein kinase activity alleviates the severity of aganglionosis by impairing CAV1/FLNA expression., PMID:40296549
A Novel Subtype of Spondylocostal Dysplasia Associated With a Heterozygous Missense FLNA Variant., PMID:40264431
Integrated bioinformatic analysis of immune infiltration and disulfidptosis related gene subgroups in type A aortic dissection., PMID:40258895
Proteomic profiles screening identified novel exosomal protein biomarkers for diagnosis of lung cancer., PMID:40229672
The FLNA Gene in Tumour-Educated Platelets Can Be Utilised to Identify High-Risk Populations for NSCLCs., PMID:40208200
The potential of ARL4C and its-mediated genes in atherosclerosis and agent development., PMID:40176913
Exome analyses unravel the genetic architecture of Mendelian dominant nonsyndromic orofacial clefts., PMID:40147726
Comment on Wang et al. Simufilam Reverses Aberrant Receptor Interactions of Filamin A in Alzheimer's Disease. Int. J. Mol. Sci. 2023, 24, 13927., PMID:40141124
Whole exome sequencing of 80 cases of sporadic mitral valve prolapse reveals novel disease-associated genes and variants in a Southern Chinese population., PMID:40131712
Identification of Ferroptosis- and Hypoxia-related Genes in iPSC-derived Oligodendrocyte Precursor Cells from Multiple Sclerosis Patients., PMID:40127044
Exploring Molecular Alterations in Breast Cancer Among Indian Women Using Label-Free Quantitative Serum Proteomics., PMID:39990193
[Duplication of the X-chromosomal Xq28 region containing the MECP2 gene in X-linked intellectual disability syndrome Lubs-type]., PMID:39987543
Filamin A suppresses the expression of ribosomal protein genes by controlling the activity of an EGR1-Sp1-GCN5/PCAF pathway in human cells., PMID:39938690
Suppressing the progression of bladder cancer using cyclovirobuxine D based on network pharmacology and bioinformatics approaches., PMID:39797986
FLNA genomic rearrangements in a 391 French bilateral periventricular nodular heterotopia cohort: prevalence and phenotypic correlations., PMID:39779312
Disulfidptosis and Its Hub Gene Slc3a2 Involved in Ulcerative Colitis Pathogenesis, Disease Progression, and Patient Responses to Biologic Therapies., PMID:39769269
Filamin A C-terminal fragment modulates Orai1 expression by inhibition of protein degradation., PMID:39764579
Lower expression of MMP2, FLNA, and CFL1 is correlated with favorable prognosis in invasive micropapillary breast cancer., PMID:39724992
Stereoelectroencephalographic thermocoagulation in FLNA-positive heterotopia: Is it an effective treatment?, PMID:39679676
Fine-tuning levels of filamins a and b as a specific mechanism sustaining Th2 lymphocyte functions., PMID:39639023
Single nuclear RNA sequencing and analysis of basal cells in pulmonary acute respiratory distress syndrome., PMID:39622393
Diagnostic and prognostic value of disulfidptosis-related genes in sepsis., PMID:39610785
Therapeutic potential of targeting the FLNA-regulated Wee1 kinase in adrenocortical carcinomas., PMID:39528354
Pulmonary hypertension in patients carrying FLNA loss-of-function variants., PMID:39510553
Splicing dysregulation in glioblastoma alters the function of cell migration-related genes., PMID:39448549
The Role of CENPK Splice Variant in Abiraterone Response in Metastatic Castration-Resistant Prostate Cancer., PMID:39404386
Unraveling the pathogenic mechanism of a novel filamin a frameshift variant in periventricular nodular heterotopia., PMID:39399465
Polyvalvular Dysplasia and Vascular Abnormalities in a Neonate With an FLNA Variant., PMID:39359981
Epithelioid Fibrous Histiocytoma Is on a Continuum With Superficial ALK -rearranged Myxoid Spindle Cell Neoplasm : A Clinicopathologic Series of 35 Cases Including Alternate RET and NTRK3 Fusions., PMID:39329254
Significance of Fibrillin-1, Filamin A, MMP2 and SOX9 in Mitral Valve Pathology., PMID:39273357
The hinge-1 domain of Flna is not necessary for diverse physiological functions in mice., PMID:39215762
HSPB8-BAG3 chaperone complex modulates cell invasion in intrahepatic cholangiocarcinoma by regulating CASA-mediated Filamin A degradation., PMID:39215616
Targeting Cleavage of C-Terminal Fragment of Cytoskeletal Filamin A in Cancers., PMID:39195282
Boolean Modeling of Biological Network Applied to Protein-Protein Interaction Network of Autism Patients., PMID:39194544
Filamin A regulates platelet shape change and contractile force generation via phosphorylation of the myosin light chain., PMID:39189664
CircRNA ATF6 suppresses bladder cancer cell proliferation and migration via miR-146a-5p/FLNA axis., PMID:39182401
Congenital short bowel syndrome: Cases series in the same family and review of literature., PMID:39173431
Reducing Filamin A Restores Cortical Synaptic Connectivity and Early Social Communication Following Cellular Mosaicism in Autism Spectrum Disorder Pathways., PMID:39164108
Targeted DNA Sequencing in Diagnosis of Malignant Phyllodes Tumors With Emphasis on Tumors With Keratin and p63 Expression., PMID:39154782
The unfolded protein response sensor PERK mediates mechanical stress-induced maturation of focal adhesion complexes in glioblastoma cells., PMID:39152526
EMA-Positive Superficial ALK-Rearranged Myxoid Spindle Cell Neoplasm Masquerading as Perineurioma/Hybrid Nerve Sheath Tumor., PMID:39150182
The effect of rs2910686 on ERAP2 expression in IBD and epithelial inflammatory response., PMID:39123229
For research use only. Not for human or drug use.
