Catalog No.
RHD72102
Species reactivity
Human, Rat
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, WB: 1:500-1:2000
Target
KLRK1, NKG2D, Killer cell lectin-like receptor subfamily K member 1, NKG2-D-activating NK receptor, D12S2489E, NKG2-D type II integral membrane protein, NK cell receptor D, CD314
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P26718
Applications
ELISA, FCM, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3H16
Two major human phenotypes of MICA molecules and their differential activation to NK cells via NKG2D receptor., PMID:40458406
NKG2D triggering hampers DNAM-1-mediated signaling in human NK cells., PMID:40421025
23ME-01473, an Fc Effector-Enhanced Anti-ULBP6/2/5 Antibody, Restores NK Cell-Mediated Antitumor Immunity through NKG2D and FcγRIIIa Activation., PMID:40116579
Frizzled-7-targeting antibody-derived bifunctional protein retargets NK cells against triple-negative breast cancer cells via MICA-NKG2D axis., PMID:40021214
Entry into the lytic cycle exposes EBV-infected cells to NK cell killing via upregulation of the MICB ligand for NKG2D and activation of the CD56bright and NKG2A+KIR+CD56dim subsets., PMID:39676862
Agonistic anti-NKG2D antibody structure reveals unique stoichiometry and epitope compared to natural ligands., PMID:39582357
MICA and NKG2D gene polymorphisms influence graft survival, and response to therapy in kidney transplantation., PMID:39575256
Bispecific killer cell engagers employing species cross-reactive NKG2D binders redirect human and murine lymphocytes to ErbB2/HER2-positive malignancies., PMID:39267747
Expression and function of the major histocompatibility complex (MHC) class I chain-related A (MICA)*010 in NK cell killing activity., PMID:39116667
NKG2D-bispecific enhances NK and CD8+ T cell antitumor immunity., PMID:39112670
A human autoimmune organoid model reveals IL-7 function in coeliac disease., PMID:39048815
Regulation of the PD-1/PD-L1 Axis and NK Cell Dysfunction by Exosomal miR-552-5p in Gastric Cancer., PMID:39020183
Memory-like differentiation enhances NK cell responses against colorectal cancer., PMID:38737793
Tinostamustine (EDO-S101), an Alkylating Deacetylase Inhibitor, Enhances the Efficacy of Daratumumab in Multiple Myeloma by Upregulation of CD38 and NKG2D Ligands., PMID:38731936
Targeting NKG2D ligands in glioblastoma with a bispecific T-cell engager is augmented with conventional therapy and enhances oncolytic virotherapy of glioma stem-like cells., PMID:38724464
Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses., PMID:38653235
Elevated levels of cell-free NKG2D-ligands modulate NKG2D surface expression and compromise NK cell function in severe COVID-19 disease., PMID:38410511
Natural Killer Cells as a Further Insight into the Course of Chronic Obstructive Pulmonary Disease., PMID:38398020
Evaluation of the TLR3 involvement during Schistosoma japonicum-induced pathology., PMID:38172683
Upregulation of the NKG2D Ligand ULBP2 by JC Polyomavirus Infection Promotes Immune Recognition by Natural Killer Cells., PMID:37774496
Dynamics of Soluble Forms of the Immune Checkpoint Components PD-1/PD-L1/B7-H3, CD314/ULBP1, and HLA-G in Peripheral Blood of Melanoma Patients Receiving Blockers of Programmed Cell Death Protein PD-1., PMID:37773572
Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality., PMID:37753084
IL-17a-producing γδT cells and NKG2D signaling mediate bacterial endotoxin-induced neonatal lung injury: implications for bronchopulmonary dysplasia., PMID:37744375
IL-15 induced bystander activation of CD8+ T cells may mediate endothelium injury through NKG2D in Hantaan virus infection., PMID:36590594
Circular EZH2-encoded EZH2-92aa mediates immune evasion in glioblastoma via inhibition of surface NKG2D ligands., PMID:35970825
CAR-NK Cells: From Natural Basis to Design for Kill., PMID:34970253
Bispecific Antibody Designed for Targeted NK Cell Activation and Functional Assessment for Biomedical Applications., PMID:34486371
Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation., PMID:34294876
Increased Concentrations of Circulating Soluble MHC Class I-Related Chain A (sMICA) and sMICB and Modulation of Plasma Membrane MICA Expression: Potential Mechanisms and Correlation With Natural Killer Cell Activity in Systemic Lupus Erythematosus., PMID:34012432
Bispecific NKG2D-CD3 and NKG2D-CD16 Fusion Proteins as Novel Treatment Option in Advanced Soft Tissue Sarcomas., PMID:33936075
Targeting the NKG2D/NKG2D-L axis in acute myeloid leukemia., PMID:33508619
Immune checkpoint expression on peripheral cytotoxic lymphocytes in cervical cancer patients: moving beyond the PD-1/PD-L1 axis., PMID:33306195
Production of a novel bispecific protein ULBP1×CD19-scFv targeting the NKG2D receptor and CD19 to promote the activation of NK cells., PMID:33122138
Mutant KRAS Promotes NKG2D+ T Cell Infiltration and CD155 Dependent Immune Evasion., PMID:32727790
Arming cytotoxic lymphocytes for cancer immunotherapy by means of the NKG2D/NKG2D-ligand system., PMID:32726145
Human Metapneumovirus Escapes NK Cell Recognition through the Downregulation of Stress-Induced Ligands for NKG2D., PMID:32698530
convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting., PMID:32518350
NKG2D-Fc fusion protein promotes antitumor immunity through the depletion of immunosuppressive cells., PMID:32468232
BCMA-targeting Bispecific Antibody That Simultaneously Stimulates NKG2D-enhanced Efficacy Against Multiple Myeloma., PMID:32349046
Dysregulated Antibody, Natural Killer Cell and Immune Mediator Profiles in Autoimmune Thyroid Diseases., PMID:32182948
Glycolysis and Oxidative Phosphorylation Play Critical Roles in Natural Killer Cell Receptor-Mediated Natural Killer Cell Functions., PMID:32153568
Enhanced activation of human NK cells by drug-exposed hepatocytes., PMID:32060585
Quantitative analysis of human NK cell reactivity using latex beads coated with defined amounts of antibodies., PMID:32027754
Improving the Clinical Application of Natural Killer Cells by Modulating Signals Signal from Target Cells., PMID:31311121
NKG2D-DAP10 signaling recruits EVL to the cytotoxic synapse to generate F-actin and promote NK cell cytotoxicity., PMID:31235500
Cord blood CD4+/CD25+ T cells down-regulates NKG2D on cytokine-induced killer cells., PMID:31136978
Overcoming Target Driven Fratricide for T Cell Therapy., PMID:30619300
A Flow Cytometric NK Cell-Mediated Cytotoxicity Assay to Evaluate Anticancer Immune Responses In Vitro., PMID:30465199
Mechanisms of NK Cell Activation and Clinical Activity of the Therapeutic SLAMF7 Antibody, Elotuzumab in Multiple Myeloma., PMID:30455698
Blockade of NKG2D/NKG2D ligand interaction attenuated cardiac remodelling after myocardial infarction., PMID:30307485
For research use only. Not for human or drug use.
